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Inventi Impact - Pharm Tech

Articles

  • Inventi:ppt/23442/17
    DEVELOPMENT AND EVALUATION OF FLOATING TABLETS OF TRIMEBUTINE MALEATE USING HYDROPHILIC POLYMERS
    Mahmoud Mohamed Ghorab, Salwa Salah, Ibrahim Salah Mousa*

    Various approaches have been used to retain the dosage form in the stomach as a way of increasing the gastric residence time, including floatation systems; high-density systems; mucoadhesive systems; magnetic systems; unfoldable, extendible or swellable systems and superporous hydrogel systems. Trimebutine maleate has a short elimination half-life and is mainly absorbed in proximal areas of GIT. The purpose of this study was to develop a gastroretentive controlled release drug delivery system for the drug. Tablet formulations were designed using hydroxypropylmethylcellulose (HPMC K15M) or hydroxypropylmethylcellulose (HPMC K100M) as release-retarding polymers and sodium bicarbonate (NaHCO3) and citric acid as a gas former. Floating behavior and drug release studies were conducted in 0.1 N HCl (pH 1.2) at 37±0.5°C. The tablets showed acceptable physicochemical properties. Drug release profiles of all formulae followed non-fickian diffusion. Statistical analyses of data revealed that tablets containing HPMC K100 (1:0.75), citric acid (4%, w/w) and NaHCO3 (3.5%, w/w) were promising systems exhibiting excellent floating properties and sustained drug release characteristics. The formulae were stored at 40°C/75% RH for 3 months according to ICH guidelines. Formula F23 showed better physical stability.

    How to Cite this Article
    Mahmoud Mohamed Ghorab, Salwa Salah, Ibrahim Salah Mousa. Development and Evaluation of Floating Tablets of Trimebutine Maleate using Hydrophilic Polymers. Inventi Impact: Pharm Tech, 2018(1):9-19, 2018.
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