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Inventi Impact - Pharm Tech

Articles

  • Inventi:ppt/24483/17
    PLEASANT TASTING GRANULES OF CLARITHROMYCIN
    Yitesh Jagwani*, Siddhraj S Sisodia

    Clarithromycin has poor acceptance by pediatric and geriatric patients due to very bitter taste. Usually, in dry syrup formulations, high concentration of sugar is used for taste masking purpose. But high consumption of sugar has been related to several chronic diseases and several times is unable to mask the extreme bitter taste. Therefore this study aimed to investigate taste masking capacity of excipients other than sugar. For this purpose, initially several granulating material were evaluated for masking the bitter taste of clarithromycin. After identifying the granulating material, combination of non caloric intense sweeteners along with granulating materials were used to achieve pleasant taste. Combination of sucralose and aspartame with hydroxy propyl cellulose miraculously removed bitterness, provided sweetness and absence of aftertaste. These taste masked granules can be used in formulation of dry syrup or tablet, which can be easily accepted by pediatric as well as by geriatric patients. The result of this study provided important information for future applications of synergistic effects of sucralose and aspartame in combination with hydroxy propyl cellulose for taste masking purposes.

    How to Cite this Article
    Yitesh Jagwani, Siddhraj S Sisodia. Pleasant Tasting Granules of Clarithromycin. Inventi Impact: Pharm Tech, 2018(2):61-63, 2018.
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