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Inventi Impact - Pharm Tech

Articles

  • Inventi:ppt/24884/18
    EFFECT OF PH ON THE EFFICACY OF THE SODIUM BENZOATE AS ANTIMICROBIAL PRESERVATIVE IN TOPICAL FORMULATION
    Shelke Om*, Kulkarni Amol

    Preservatives are used to maintain the microbiological attributes of the formulation throughout the shelf life. Sodium benzoate is used as preservative in oral, parenteral and topical formulations. Antimicrobial effectiveness testing (AET) was carried out using different concentration of sodium benzoate at different pH levels. Bacteria Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and fungi Candida albicans, Aspergillus niger were challenged for the study. Sodium benzoate concentration has studied in range 0.05-0.5% and pH range of formulations has studied 4.0-6.5. Sodium benzoate had passed the AET test as per USP for pH range 4.0-6.5 and sodium benzoate concentration 0.075 to 0.5% but AET test fails at sodium benzoate concentration 0.05%.

    How to Cite this Article
    Shelke Om, Kulkarni Amol. Effect of pH on the Efficacy of the Sodium Benzoate as Antimicrobial Preservative in Topical formulation. Inventi Impact: Pharm Tech, 2018(2):64-67, 2018.
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