­
­
­
­

Inventi Impact - Pharm Tech

Articles

  • Inventi:ppt/25665/18
    FORMULATION AND EVALUATION OF MONTELUKAST SODIUM FAST DISSOLVING TABLETS
    Shiva Kumar Yellanki*, Teelavath Mangilal, M Sushanth

    The demand for fast dissolving tablet (FDT) has been growing during the last decade especially for elderly people and children who have swallowing difficulties. Montelukast is a leukotriene receptor antagonist (LTRA), anti-asthmatic used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is effective in relieving nasal congestion, particularly in patients with allergic rhinitis. In present work an attempt has been made to prepare fast dissolving tablets of montelukast sodium with increased rate of dissolution may leads to increase bioavailability. In present work fast dissolving tablet of montelukast sodium prepared using crosscarmellose sodium, sodium starch glycolate and kollidon cl-m as superdisintegrants by direct compression method. The tablets were evaluated for various parameters like weight variation, hardness, friability, in-vitro dispersion time, drug-polymer interaction, drug content water absorption ratio, wetting time, invitro drug release. The tablet prepared by direct compression method passed weight variation in the range 113 to 121 mg which is below ±7.5%, hardness 3.69±0.25 to 3.51±0.27 kg/cm2, percentage friability of 0.22 to 0.37%, in-vitro disintegration time of 51 to17 sec, drug content uniformity was in between 98.23 to 98.75%, water absorption ratio were found between 61 to 38% and wetting time between 58.23 to 21.12 seconds, maximum drug release 87.75 to 98.75% shown within 10 min. FTIR study showed that there was no drug interaction with formulation additives of the tablet.

    How to Cite this Article
    Shiva Kumar Yellanki, Teelavath Mangilal, M Sushanth. Formulation and Evaluation of Montelukast Sodium Fast Dissolving Tablets. Inventi Impact: Pharm Tech, 2018(3):116-122, 2018.
    Download Full Text