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Inventi Impact - Veterinary Science

Articles

  • Inventi:hvet/20089/16
    HAEMATOLOGICAL ALTERATIONS IN RATS DUE TO DOXORUBICIN AND ITS AMELIORATION BY ASCORBIC ACID AND SPIRULINA
    Y Ravi Kumar *, Y Anjaneyulu, S Arundhathi, D Madhuri, A Anand Kumar, A Gopala Reddy

    The present study was undertaken to elucidate the toxic effects of doxorubicin on different alterations especially haematological parameters. A total of 24 healthy female Wistar rats were reared for three weeks and then randomly divided into 4 groups of 6 in each. Group 1-Control, Group 2-Doxorubicin – Toxic control @ 2 mg/kg body wt. by intravenous injection for 5 days followed by weekly once for 2 weeks, Group 3-Pre treatment with ascorbic acid @ 500 mg/g feed by enteral route for 7 days followed by intravenous injection of doxorubicin as mentioned in group 2. Ascorbic acid supplementation was continued during these 19 days, Group 4-Pre treatment with Spirulina @ 1000 mg/kg feed by enteral route for 7 days followed by intravenous injection of doxorubicin as mentioned in group 2. Spirulina supplementation was continued during these 19 days. Body weights were recorded on zero day, last day and haematological parameters were estimated and analyzed statistically in the samples collected at the end of experiment. Body weights, heart weights and heart weight/body weight ratio were significantly (P<0.05) reduced in group 2 but in group 3 and 4 there was moderate reduction in these parameters. Haematological studies revealed that overall means of TEC, Hb, TLC and PCV were significantly (P<0.05) reduced in group 2 in comparison to other groups. The ameliorative groups 3 and 4 showed mild to moderate improvement in all parameters in comparison to group 2.

    How to Cite this Article
    Y Ravi Kumar, Y Anjaneyulu, S Arundhathi et al. Haematological Alterations in Rats Due to Doxorubicin and Its Amelioration by Ascorbic Acid and Spirulina. Inventi Impact: Veterinary Science, 2016(4):182-184, 2016.
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