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Inventi Impact - Biomedical Engineering

Articles

  • Inventi:ebe/8838/14
    ELECTROCHEMOTHERAPY: FROM THE DRAWING BOARD INTO MEDICAL PRACTICE
    Damijan Miklavcic, Barbara Mali, Bor Kos, Richard Heller, Gregor Sersa

    Electrochemotherapy is a local treatment of cancer employing electric pulses to improve transmembrane transfer of cytotoxic drugs. In this paper we discuss electrochemotherapy from the perspective of biomedical engineering and review the steps needed to move such a treatment from initial prototypes into clinical practice. In the paper also basic theory of electrochemotherapy and preclinical studies in vitro and in vivo are briefly reviewed. Following this we present a short review of recent clinical publications and discuss implementation of electrochemotherapy into standard of care for treatment of skin tumors, and use of electrochemotherapy for other targets such as head and neck cancer, deep-seated tumors in the liver and intestinal tract, and brain metastases. Electrodes used in these specific cases are presented with their typical voltage amplitudes used in electrochemotherapy. Finally, key points on what should be investigated in the future are presented and discussed.

    How to Cite this Article
    CC Compliant Citation: Miklavcicet et al.: Electrochemotherapy: from the drawing board into medical practice. BioMedical Engineering OnLine 2014 13:29, doi:10.1186/1475-925X-13-29. © 2014 Miklav?i? et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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