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Inventi Impact - NDDS

Articles

  • Inventi:pndds/24893/18
    BISOPROLOL HEMIFUMARATE MATRIX TABLETS FOR SUSTAINED RELEASE: PREPARATION AND EVALUATION
    Saadia A Tayel, Nagwa Foda, Dina Louis*

    Bisoprolol hemifumarate is a selective beta-1-blocker used in the treatment of coronary heart failure. It is characterized by being freely water soluble. Very limited trials were developed to prepare sustained release dosage forms of this drug. In this work, bisoprolol hemifumarate formulated as matrix tablets containing 20 mg of the drug so as to extend its release over a period of more than five hours. Two groups of polymers were used: hydrophilic matrices including carboxymethyl cellulose and carbopol 974 and lipid matrices including stearyl alcohol and carnauba wax. These matrices were prepared at the following drug: polymer ratios 1:1, 1:3 and 1:4. Prepared tablets were examined for their hardness, friability, drug content and percentage of drug released. Stearyl alcohol used at a ratio of 1:4 brought about a percentage of drug released of 57.18% (±3.7) after 5 h and tablets exhibited zero order release rate. Carbopol at 1:4 ratio showed a zero order release with 73.52% (±8.7) of the drug released after 5 h.

    How to Cite this Article
    Saadia A Tayel, Nagwa Foda, Dina Louis. Bisoprolol Hemifumarate Matrix Tablets for Sustained Release: Preparation and Evaluation. Inventi Impact: NDDS, 2018(2):69-73, 2018.
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