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Inventi Impact - NDDS

Articles

  • Inventi:pndds/25156/18
    DEVELOPMENT AND CHARACTERIZATION OF COLON PH TRIGGERED MULTIPARTICULATE DRUG DELIVERY SYSTEM FOR ULCERATIVE COLITIS
    Shiva Kumar Yellanki*, B Mamatha

    The purpose of the present study was to develop and characterize mesalamine microsphere to target colon for ulcerative colitis. Mesalamine is a drug with low solubility so in order to increase its solubility the solid dispersions of mesalamine were prepared by using kneading method with three different carriers, poly vinyl pyyrolidone (PVP K-30), poly ethylene glycol (PEG 4000) and β-cyclodextrin and evaluated for solubility determination. The solid dispersion (F15) drug: β- cyclodextrin (1:3) was selected for further formulation of microspheres due to its high solubility (4.268±0.031 mg/ml). The microspheres were prepared by using solvent evaporation method. The polymers used were Eudragit L 100 and Eudragit S 100 and glutaraldehyde is used as cross linking agent. The prepared formulations of microspheres were characterized for various parameters like particle size analysis, scanning electron microscopy, micromeritic properties, percentage yield, drug content, entrapment efficiency, in-vitro release studies and stability studies. The micromeritic properties like angle of repose, Hausner’s ratio and Carr’s index showed good flow properties for all the formulations. The particle size of all formulations was in the range of 203±14 to 437±24 μm. The in-vitro studies revealed that the M6 formulation showed the drug release of 95.12% in a controlled manner up to 14 hrs and the best fit model was Hixson and Crowell which shows that drug release is mainly by dissolution.

    How to Cite this Article
    Shiva Kumar Yellanki, B Mamatha. Development and Characterization of Colon pH Trigerred Multiparticulate Drug Delivery System for Ulcerative Colitis. Inventi Impact: NDDS, 2018(3):147-151, 2018.
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