­
­
­
­

Inventi Impact - NDDS

Articles

  • Inventi:pndds/718/13
    EFFECT OF RELEASE MODIFIER ON HYDRODYNAMICALLY BALANCED SYSTEM OF KETOPROFEN FOR SUSTAINED DELIVERY SYSTEM
    Reetika Ganjoo, Shashank Soni, Veerma Ram

    The purpose of present investigation is to develop HBS tablet of Ketoprofen (KTF) for sustained delivery system. Prepared HBS tablets shows better characteristics in term of physical properties. Our basic purpose was to study the effect of release modifier polymers with incorporation of low viscosity sodium alginate. Tablets were prepared by using direct compression technique. Formulation F1 shows burst effect without addition of any release modifier but with addition of release modifier polymer formulation F2 and F5 shows better profile. Zero order release kinetics was obtained from the formulations. Our results suggests that the Sodium Alginate LV (SA) and in combination with HPMC is an excellent material for stomach specific sustained delivery of KTF from hydrodynamically balanced single unit tablets.

    Download Full Text