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Inventi Impact - Pharm Analysis & Quality Assurance

Articles

  • Inventi:ppaqa/25730/18
    RP-HPLC METHOD DEVELOPMENT FOR THE DETERMINATION OF RIZATRIPTAN BENZOATE IN BULK DRUG AND TABLET DOSAGE FORM
    Pushpa Latha E*, Sailaja B

    A simple, rapid, accurate, precise and reproducible RP-HPLC method for the estimation of rizatriptan benzoate in bulk and tablet dosage form was developed and validated as per ICH guidelines. The separation was done using Enable C18 G 150 x 4.6 mm, 5μ column. The mobile phase (water and methanol; 80:20% v/v) was pumped at 1.0 ml/min and effluent was detected at 225 nm using a PDA detector. The retention time was 2.417 min and the method produced linear response in the concentration range of 1-10 μg/ml (r2 - 0.999). In recovery studies, %RSD from reproducibility was found to be below 2%. LOD and LOQ were 0.34 μg/ml and 1.036 μg/ml respectively. The developed RP-HPLC method was found to be effective, sensitive and specific for the estimation of rizatriptan benzoate in bulk and tablet dosage form.

    How to Cite this Article
    Pushpa Latha E, Sailaja B. RP-HPLC Method Development for the Determination of Rizatriptan Benzoate in Bulk Drug and Tablet Dosage Form. Inventi Impact: Pharm Analysis & Quality Assurance, 2018(4):135-139, 2018.
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