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Inventi Impact - Pharm Analysis & Quality Assurance

Articles

  • Inventi:ppaqa/28707/19
    ESTIMATION OF ARTICAINE HCL AND EPINEPHRINE BY VOLTAMMETRY USING NANOMODIFIED ZIRCONIUM ELECTRODE IN BULK AND PHARMACEUTICAL DOSAGE FORM
    Hassan A M Hendawy, Sherin F Hammad, Lories A Bebawy, Marian A Girges*

    Uncomplicated, accurate and short analysis time analysis was elaborated for quantification of Articaine HCl (ART HCl) and Epinephrine (EPI). The electrochemical behavior of both articaine and epinephrine was carried out by applying differential pulse voltammetry (DPV) using Pencil graphite (PGE), carbon paste (CPE) and Nanomodified zirconium (ZRE) electrodes. The effect of experimental parameters has been investigated and optimized. The peak current linearity range were 6.62 × 10-5 - 50.60 × 10-5 mol L-1 for ART and 9.90 ×10-5 - 29.1 ×10-5 mol L-1 for EPI using (PGE), 3.90 × 10-5 -15.7× 10-5 mol L-1 for ART 4.97× 10-5 - 17.7 x10-5 mol L-1 for EPI, using (CPE) 5.96 × 10-5 - 23.4x10-5 mol L-1 for ART and 2.99×10-5- 22.5 × 10-5 mol L-1 for EPI using (ZRE). The suggested analysis has been applied for assay of ART and EPI in bulk, pharmaceuticals as well as in healthy human urine with good analytical results. Comparative validation steps were done contrasted with reference (HPLC) methods.

    How to Cite this Article
    Hassan A M Hendawy, Sherin F Hammad, Lories A Bebawy et al. Estimation of Articaine HCl and Epinephrine by Voltammetry Using Nanomodified Zirconium Electrode in Bulk and Pharmaceutical Dosage Form. Inventi Impact: Pharm Analysis & Quality Assurance, 2019(3):122-129, 2019.
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