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Inventi Impact - Med Chem

Articles

  • Inventi:pmc/25739/18
    SYNTHESIS AND EVALUATION OF NOVEL 1-SUBSTITUTED 7-AZAISATIN DERIVATIVES AS ANTI MICROBIAL AGENTS
    Siddartha Kumar P*, Harinathbabu V, Basaveswara Rao M V

    A series of novel 1-substituted 7-azaisatin derivatives synthesized from 7-azaindole by oxidation with N bromosuccinamide further involves incorporation of isonicotino-hydrazide with 7-aza isatin then treated with various alkyl halides to give titled compounds and screened for antimicrobial activity. In view of the antimicrobial property of this pharmacophore it was visualized that its combined effect with an active moiety may result in increased antimicrobial activity. All the synthesized titled compounds exhibited excellent to moderate antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Proteus vulgaris, Escherichia coli and two fungal strains Candida albicans, Aspergillus niger.

    How to Cite this Article
    Siddartha Kumar P, Harinathbabu V, Basaveswara Rao M V. Synthesis and Evaluation of Novel 1-Substituted 7-Azaisatin Derivatives as anti Microbial Agents. Inventi Impact: Med Chem, 2018(4):170-175, 2018.
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