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Inventi Impact - Med Chem

Articles

  • Inventi:pmc/25766/18
    SYNTHESIS AND EVALUATION OF ANTIBACTERIAL ACTIVITY OF BENZAL AND ITS DERIVATIVES
    Sowjanya Pulipati*, P Srinivasa Babu, Sk Anjum Kausar, Sk Fathima Sani, K Hima Bindu, A Swapna, N Jyothirmayee

    Benzal derivatives were synthesized by crossed aldol. Benzalacetone synthesis was done by crossed aldol condensation between benzaldehyde and acetone with 1:1 mol ratio, while dibenzalacetone in 2:1 mol ratio. Benzalacetone derivatives were synthesized by replacing benzaldehyde with its derivatives, i.e. anisaldehyde, salicylacetone, cinnamaldehyde and p-hydroxyl benzalacetone. The mono derivatives and di derivatives were synthesized by changing the concentration of benzaldehyde. The synthesized compounds showed good antibacterial activity. The antibacterial activity was determined by agar well diffusion method against E. coli and Bacillus subtilis for all benzal derivatives and its was found that mono salicylalacetone exhibited highest antibacterial activity against B. subtilis and least activity was produced by p-hydroxyl benzalacetone for both E. coli and B. subtilis.

    How to Cite this Article
    Sowjanya Pulipati, P Srinivasa Babu, Sk Anjum Kausar et al. Synthesis and Evaluation of Antibacterial Activity of Benzal and Its Derivatives. Inventi Impact: Med Chem, 2018(4):176-183, 2018.
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