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Inventi Impact - Surgery
(Formerly Inventi Rapid/Impact: Cosmetic Surgery)

Articles

  • Inventi:hcs/79/14
    CLINICAL OUTCOMES FOR BREAST CANCER PATIENTS UNDERGOING MASTECTOMY AND RECONSTRUCTION WITH USE OF DERMACELL, A STERILE, ROOM TEMPERATURE ACELLULAR DERMAL MATRIX
    Christopher Vashi

    Background. Decellularized human skin has been used in a variety of medical applications, primarily involving soft tissue reconstruction, wound healing, and tendon augmentation. Theoretically, decellularization removes potentially immunogenic material and provides a clean scaffold for cellular and vascular in growth. The use of acellular dermal matrix in two-stage postmastectomy breast reconstruction is described. Methods. Ten consecutive breast cancer patientswere treated with mastectomies and immediate reconstruction from August to November 2011. There were 8 bilateral and 1 unilateral mastectomies for a total of 17 breasts, with one exclusion for chronic tobacco use. Reconstruction included the use of a new 6 × 16 cm sterile, room temperature acellular dermal matrix patch (DermACELL) soaked in a cefazolin bath. Results. Of the 17 breasts, 15 reconstructions were completed; 14 of them with expander to implant sequence and acellular dermal matrix. Histological analysis of biopsies obtained during trimming of the matrix at the second stage appeared nonremarkable with evidence of normal healing, cellularity, and vascular infiltration. Conclusion. Postoperative observations showed that this cellular dermal matrix appears to be an appropriate adjunct to reconstruction with expanders. This acellular dermal matrix appeared to work well with all patients, even those receiving postoperative chemotherapy, postoperative radiation, prednisone, or warfarin sodium.

    How to Cite this Article
    CC Compliant Citation: Christopher Vashi, “Clinical Outcomes for Breast Cancer Patients Undergoing Mastectomy and Reconstruction with Use of DermACELL, a Sterile, Room Temperature Acellular Dermal Matrix,” Plastic Surgery International, vol. 2014, Article ID 704323, 7 pages, 2014. doi:10.1155/2014/704323. Copyright © 2014 Christopher Vashi. This is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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