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Inventi Impact - Pharmacokinetics & Pharmacodynamics

Articles

  • Inventi:pkd/16391/15
    EFFECT OF QUETIAPINE ON PHARMACOKINETICS OF PIOGLITAZONE
    Bhupalam Pradeepkumar*, Y Padmanabha Reddy, N Devanna

    The present study was performed to investigate the effect of quetiapine on the pharmacokinetics of pioglitazone. The blood samples were collected and analyzed for estimation of pioglitazone pharmacokinetics. The quetiapine alters the pharmacokinetics of pioglitazone. Quetiapine appears to produce pharmacokinetic interaction with pioglitazone. The increase in pioglitazone concentration might be due to interaction of quetiapine at metabolic enzyme CYP3A4. Increase in AUC indicates the raised bioavailability in presence of quetiapine. The results of present study indicated that quetiapine has influence on pharmacokinetics of pioglitazone. The concomitant administration of pioglitazone and quetiapine should be used in caution.

    How to Cite this Article
    Bhupalam Pradeepkumar, Y Padmanabha Reddy, N Devanna. Effect of Quetiapine on Pharmacokinetics of Pioglitazone. Inventi Impact: Pharmacokinetics & Pharmacodynamics, 2015(4):160- 163, 2015.
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