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Inventi Impact - Pharmacokinetics & Pharmacodynamics

Articles

  • Inventi:pkd/24840/18
    PHARMACOKINETICS AND PHARMACODYNAMICS EVALUATION OF TRAMADOL IN THE MORE VERSIBLE GELS
    Juliana Zampoli Boava Papini, Cintia Maria Saia Cereda, Jose Pedrazzoli Junior, Silvana Aparecida Calafatti, Daniele Ribeiro de Araujo, Giovana Radomille Tofoli

    We evaluated pharmacokinetics (PK) and pharmacodynamics (PD) induced by new formulations of tramadol (TR) in thermoreversible gels. The poloxamer- (PL-) tramadol systems were prepared by direct dispersion of the drug in solutions with PL 407 and PL 188. The evaluated formulations were as follows: F1: TR 2% in aqueous solution and F2: PL 407 (20%) + PL 188 (10%) + TR 2%; F3: PL 407 (25%) + PL 188 (5%) + TR 2%; F4: PL 407 (20%) + TR 2%. New Zealand White rabbits were divided into four groups (

    How to Cite this Article
    CC Compliant Citation: Juliana Zampoli Boava Papini, Cíntia Maria Saia Cereda, José Pedrazzoli Júnior, Silvana Aparecida Calafatti, Daniele Ribeiro de Araújo, and Giovana Radomille Tofoli, “Pharmacokinetics and Pharmacodynamics Evaluation of Tramadol in Thermoreversible Gels,” BioMed Research International, vol. 2017, Article ID 5954629, 7 pages, 2017. doi:10.1155/2017/5954629, https://creativecommons.org/licenses/by/4.0/.
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