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Inventi Impact - Gene Medicines

Articles

  • Inventi:pgm/97/14
    EXTRACELLULAR MATRIX MACROMOLECULES: POTENTIAL TOOLS AND TARGETS IN CANCER GENE THERAPY
    Annele Sainio, Hannu Jarvelainen

    Tumour cells create their own microenvironment where they closely interact with a variety of soluble and non-soluble molecules, different cells and numerous other components within the extracellular matrix (ECM). Interaction between tumour cells and the ECM is bidirectional leading to either progression or inhibition of tumourigenesis. Therefore, development of novel therapies targeted primarily to tumour microenvironment (TME) is highly rational. Here, we give a short overview of different macromolecules of the ECM and introduce mechanisms whereby they contribute to tumourigenesis within the TME. Furthermore, we present examples of individual ECM macromolecules as regulators of cell behaviour during tumourigenesis. Finally, we focus on novel strategies of using ECM macromolecules as tools or targets in cancer gene therapy in the future.

    How to Cite this Article
    CC Compliant Citation: Sainio and Järveläinen: Extracellular matrix macromolecules: potential tools and targets in cancer gene therapy. Molecular and Cellular Therapies 2014 2:14, doi:10.1186/2052-8426-2-14. © 2014 Sainio and Järveläinen; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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