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Inventi Impact - Biosimilars

Articles

  • Inventi:pbs/71/14
    COMPARATIVE EVALUATION OF RECOMBINANT PROTEIN PRODUCTION IN DIFFERENT BIOFACTORIES: THE GREEN PERSPECTIVE
    Matilde Merlin, Elisa Gecchele, Stefano Capaldi, Mario Pezzotti, Linda Avesani

    In recent years, the production of recombinant pharmaceutical proteins in heterologous systems has increased significantly. Most applications involve complex proteins and glycoproteins that are difficult to produce, thus promoting the development and improvement of a wide range of production platforms. No individual system is optimal for the production of all recombinant proteins, so the diversity of platforms based on plants offers a significant advantage. Here, we discuss the production of four recombinant pharmaceutical proteins using different platforms, highlighting from these examples the unique advantages of plantbased systems over traditional fermenter-based expression platforms.

    How to Cite this Article
    CC Compliant Citation: Matilde Merlin, Elisa Gecchele, Stefano Capaldi, Mario Pezzotti, and Linda Avesani, “Comparative Evaluation of Recombinant Protein Production in Different Biofactories: The Green Perspective,” BioMed Research International, vol. 2014, Article ID 136419, 14 pages, 2014. doi:10.1155/2014/136419 Copyright © 2014 Matilde Merlin et al. This is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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