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Inventi Impact - Molecular Modeling

Articles

  • Inventi:pmm/20990/16
    MOLECULAR DOCKING AND ADMET PROPERTIES OF ALKALOIDS FROM MARINE SPONGES ACTS AS POTENT INHIBITORS FOR BREAST CANCER
    Saradha Arumugam*, S Saravanan

    Porifera have long been a reservoir for the discovery of bioactive compounds and drug discovery. Marine natural products are able to interact with many specific targets within the cell and are finding increasing use as probes to interrogate biological systems as part of chemical genomics and related research. The alarming increase in the global cancer death toll has fueled the quest for new effective anti-tumor drugs thorough in-silico screening of both terrestrial and marine organisms. Drug discovery has been carried out by computational methods using Schrodinger software, many poses of docked complex shows good interactions and binding interface were identified by Ligplot. Further studies on in-vitro and in-vivo were required to confirm their inhibitor effect on breast cancer. Docking studies gives optimism for the isolation of new bioactive compounds from a relatively unexplored source.

    How to Cite this Article
    Saradha Arumugam, S Saravanan. Molecular Docking and ADMET Properties of Alkaloids from Marine Sponges Acts as Potent Inhibitors for Breast Cancer. Inventi Impact: Molecular Modeling, 2017(2):53-56, 2017.
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