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Inventi Impact - Molecular Modeling

Articles

  • Inventi:pmm/21337/16
    ADME PROPERTIES OF CHEMICAL CONSTITUENTS INHIBITORS FOR CANCER DISEASE FROM MARINE SPONGES - A POTENTIAL DRUGS FINDING
    Saradha Arumugam*, S Saravanan

    Cancer systems biology is already addressing pressing challenges in the development of new anti-cancer therapies and is poised to take an even more leading role in our quest for deeper insights into the biological complexity of cancer. A potentially fruitful opportunity for new bioactive marine secondary metabolites lies within the cold water regions of the earth, where little, but promising, research has been completed in the world wide. Marine sponges have provided a vast resource in the search for bioactive secondary metabolites and potential drug leads. This article discusses about the ADME properties of bioactive molecules that have been discovered and the particular significance of a recent sponge possesses medicinal values particularly in various anti-cancer activities including anti-angiogenic, anti-proliferative, topoisomerase inhibition, tubulin disruption and apoptosis inducers followed by antidiabetic, antiinflammatory. Bromotopsentin (94.73) is the highest percentage of human oral consumption of compounds and the least value is Lissoclinidine (51.16) among the 24 compounds respectively.

    How to Cite this Article
    Saradha Arumugam, S Saravanan. ADME Properties of Chemical Constituents Inhibitors for Cancer Disease from Marine Sponges - A Potential Drugs Finding. Inventi Impact: Molecular Modeling, 2017(2):62-64, 2017.
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