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Inventi Impact - Biomedical Analysis

Articles

  • Inventi:pba/15395/15
    IN-VIVO INTERACTION STUDY OF MOXIFLOXACIN WITH CALCIUM AND IRON SUPPLEMENT
    Bimalkumar Patel*, N P Jivani, Akruti Khodakiya, Krishnaveni N, Saswat Parida, Sibanarayana Acharya

    Moxifloxacin is a fourth generation synthetic fluoroquinolone antibacterial agent active against gram negative and gram positive bacteria. Clinical studies show that cationic preparation decreases absorption of various quinolone antibiotics to a great extant. The objective of the study was to develop and validate a simple chromatographic method for estimating moxifloxacin in analytical and bioanalytical samples, along with the study of interaction between moxifloxacin with calcium and iron supplements. Mobile phase developed as acetonitrile: 25 mM potassium dihydrogen orthophosphate (pH 2.5) in ratio 85:15 v/v with flow rate 1 ml/min and detection wavelength 294 nm. The developed method was validated for accuracy, precision, LOD, LOQ, linearity and range. The peak plasma concentration i.e. Cmax after administration of moxifloxacin was 6.2548 ?g/ml at 180 min (Tmax). The Cmax of moxifloxacin administered along with calcium supplement and iron supplement were found to be 3.2459 and 3.9543 ?g/ml respectively. The AUC of bioavailability curve was decrease to 44 and 31% due to calcium and iron presence respectively. This reduction in moxifloxacin bioavailability suggests that cations may forms complex with moxifloxacin leads to the decrease in bioavailability. This food supplement-drug interaction rat model may be useful in prediction of potential food-drug interactions in humans and also can be utilized as a preclinical tool for interaction study.

    How to Cite this Article
    Bimalkumar Patel, N P Jivani, Akruti Khodakiya et al. In-vivo Interaction Study of Moxifloxacin with Calcium and Iron Supplement. Inventi Impact: Biomedical Analysis, 2015(3):102-107, 2015.
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