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Inventi Impact - Pharmaceutical Process Development

Articles

  • Inventi:ppd/19594/16
    PREPARATION, CHARACTERIZATION AND EVALUATION OF PECTIN- CURCUMIN NANOSUSPENSION
    Meenakshi Bhatia*, Parina kumari

    In this study, nanosuspensions of pectin were prepared by combination of antisolvent precipitation and homogenization technique containing curcumin as a model drug. Three different batches were prepared having different concentration of pectin (0.075 % - 0.30 %). The aim of this study was to increase the solubility of drug by reducing the particles size and converting the liquid into solid formulation. The pectin-curcumin (PC) nanosuspension was lyophilized and encapsulated in capsule shell. The PC nanosuspensions so formed were characterized by PSA (particle size analysis), PDI (polydispersibility index), drug content, percent entrapment efficiency, TEM (Transmission electron microscopy), DSC (Differential scanning calorimetry), XRD (X–ray diffraction) and FTIR studies and further evaluated for weight variation, disintegration and in-vitro release study. Stability studies were also performed for a period of 60 days at three different temperatures (4

    How to Cite this Article
    Meenakshi Bhatia, Parina Kumari. Preparation, Characterization and Evaluation of Pectin- Curcumin Nanosuspension. Inventi Impact: Pharmaceutical Process Development, 2016(4):177-185, 2016.
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