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Inventi Impact - Pharmaceutical Process Development

Articles

  • Inventi:ppd/20870/16
    MICROWAVE ASSISTED SYNTHESIS AND CHARACTERIZATION OF ACRYLAMIDE GRAFTED CASSIA: APPLICATION IN DRUG DELIVERY SYSTEM
    Komal Saini*, Priyanka Nagar

    Polysaccharides are a natural and renewable reservoir which can be tailored to obtain a broad spectrum of macromolecular materials. Grafting is the versatile and convenient route to develop polysaccharide based materials. In the present study, an approach was made to prepare and evaluate the fast dissolving tablet of salbutamol sulphate formed by graft cassia seed extract polymer by direct compression method. The graft copolymerization of acrylamide on cassia was done by microwave assisted method using ceric ammonium nitrate as cross linker. The graft copolymerized cassia was characterized by FTIR, DSC, SEM studies and confirmed the formation of graft copolymer. Grafting was done by microwave assisted method by varying the concentration of acrylamide. Maximum grafting efficiency (60%) was observed at higher concentration of acrylamide. The tablets were evaluated for various pharmacopoeial parameters i.e. weight variation, friability, hardness, thickness and diameter, disintegration test and in-vitro release. On comparative evaluation, it was observed that graft copolymerized cassia showed higher disintegration while the dissolution studies revealed that more than 80% of drug was released in 15 minutes. The release rate data was fitted to various release kinetic models. It was found that formulations F0, F1 F2 and Fm followed Korsemeyer-Peppas model, while the F3 shows anomalous transport mechanism of drug release. Therefore, it may be concluded that the seed extract of cassia is a candidate as a carrier for drug delivery system. Hence it possesses the scope for exploring it for further pharmaceutical application.

    How to Cite this Article
    Komal Saini, Priyanka Nagar. Microwave Assisted Synthesis and Characterization of Acrylamide Grafted Cassia: Application in Drug Delivery System. Inventi Impact: Pharmaceutical Process Development, 2017(1):1-7, 2017.
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