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Inventi Impact - Biomedical Imaging

Articles

  • Inventi:ebmi/61/14
    ANIMAL STUDY ASSESSING SAFETY OF AN ACOUSTIC COUPLING FLUID THAT HOLDS THE POTENTIAL TO AVOID SURGICALLY INDUCED ARTIFACTS IN 3D ULTRASOUND GUIDED OPERATIONS
    Asgeir S Jakola, Arve Jorgensen, Tormod Selbekk, Ralf-Peter Michler, Ole Solheim, Sverre H Torp, Lisa MSagberg, Petter Aadahl, Geirmund Unsgard

    Background: Use of ultrasound in brain tumor surgery is common. The difference in attenuation between brain and isotonic saline may cause artifacts that degrade the ultrasound images, potentially affecting resection grades and safety. Our research group has developed an acoustic coupling fluid that attenuates ultrasound energy like the normal brain. We aimed to test in animals if the newly developed acoustic coupling fluid may have harmful effects. Methods: Eight rats were included for intraparenchymal injection into the brain, and if no adverse reactions were detected, 6 pigs were to be included with injection of the coupling fluid into the subarachnoid space. Animal behavior, EEG registrations, histopathology and immunohistochemistry were used in assessment. Results: In total, 14 animals were included, 8 rats and 6 pigs. We did not detect any clinical adverse effects, seizure activity on EEG or histopathological signs of tissue damage. Conclusion: The novel acoustic coupling fluid intended for brain tumor surgery appears safe in rats and pigs under the tested circumstances.

    How to Cite this Article
    CC Compliant Citation: Jakola et al.: Animal study assessing safety of an acoustic coupling fluid that holds the potential to avoid surgically induced artifacts in 3D ultrasound guided operations. BMC Medical Imaging 2014 14:11, doi:10.1186/1471-2342-14-11. © 2014 Jakola et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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