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Inventi Rapid - Pharm Tech

Articles

  • Inventi:ppt/25752/18
    FORMULATION AND IN-VITRO EVALUATION OF FLOATING TABLETS OF TERBUTALINE SULPHATE
    Naina Gujarathi, Kamere Kishore*, Gampa Vijay Kumar

    The research was to develop floating tablets of terbutaline sulphate (TBS). The floating tablets were prepared by direct compression method. Initially the concentration of gas generating agent i.e., sodium bicarbonate was optimized. Then the formulation was developed by using different concentrations of xanthan gum, guar gum, karaya gum as release retarding polymers. The formulation blend was subjected to various preformulation studies and all the formulations were found to be good indicating that the powder blend has good flow and compressibility properties. The formulated tablets were subjected to quality control tests. Among all the formulations, the formulation prepared with guar gum 50 mg, released the drug upto 12 hours (F4 = 99.89). The optimized formulation dissolution data was subjected to release kinetics. R2 value for zero order was 0.9959, R2 value for first order was 0.9699, optimized formula follows zero order in releasing the drug from dosage form.

    How to Cite this Article
    Naina Gujarathi, Kamere Kishore, Gampa Vijay Kumar. Formulation and In-Vitro Evaluation of Floating Tablets of Terbutaline Sulphate. Inventi Rapid: Pharm Tech, 2018(3): 1-9, 2018.
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