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Inventi Rapid - Pharm Tech

Articles

  • Inventi:ppt/27172/18
    FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING MICROSPHERES OF NICARDIPINE
    Shiva Kumar Yellanki*, M Naga Prashanthi, M Ravi Kumar

    The present study was aimed at development of gastroretentive floating microspheres of nicardipine for controlled release and to develop innovative and suitable dosage form by the use of various polymers. Nicardipine is an antihypertensive drug it is a dihydropyridine calcium-channel blocking agent used to treat the vascular disorders such as chronic stable angina, hypertension. Different floating microspheres formulations were prepared using different polymers like locust bean gum, gellan gum, Eudragit S 100, Eudragit L 100, sodium alginate in various combination ratios by ionotropic gelation method. All the developed formulations were subjected to various evaluation parameters such as particle size, micromeritic study, percentage yield, drug entrapment efficiency, in-vitro buoyancy, swelling index, floating behaviour, in-vitro drug release scanning electron microscopy (SEM) and stability studies. Optimized formulation was decided based on drug release studies, buoyancy studies, percentage yield, gastro retention time, swelling index, zero order, first order, Higuchi model, korsmeyer peppas model. Formulation containing sodium alginate and locust bean gum in combination (F3) exhibited maximum drug release of 97.33% for 12 hrs and scanning electron microscopy (SEM) revealed smooth surface characteristics with less particle size and good flow properties hence it was confirmed as the optimized formulation.

    How to Cite this Article
    Shiva Kumar Yellanki, M Naga Prashanthi, M Ravi Kumar. Formulation and Evaluation of Gastroretentive Floating Microspheres of Nicardipine. Inventi Rapid: Pharm Tech, 2019(2):1-9, 2019.
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