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Inventi Rapid - Pharm Tech

Articles

  • Inventi:ppt/27920/19
    FORMULATION AND EVALUATION OF CARVEDILOL PHOSPHATE SUBLINGUAL TABLET
    Madibone M N, Bhokare S G*, P B Jadhav

    Sublingual tablets of Carvedilol phosphate were prepared to improve its bioavailability, to avoid pre-systemic metabolism in the gastrointestinal tract and hepatic first pass elimination. The Sublingual tablets were prepared by direct compression procedure using different concentration of F-Melt, Beal Fruit Gum and microcrystalline cellulose. Compatibility studies of drug and polymer were performed by FTIR spectroscopy and DSC. Preformulation property of API was evaluated. Post compressional parameters such disintegration time, wetting time, water absorption ratio, in-vitro drug release and in-vivo bioavailability study of optimized formulation were determined. FTIR spectroscopy and DSC study revealed that there was no possible interaction between drug and polymers. The precompression parameters were in acceptable range of pharmacopoeial specification. The disintegration time of optimized formulation (F7) was upto 25 sec. The percentage relative bioavailability of carvedilol phosphate from optimized sublingual tablets was found to be 98.48%. Sublingual tablets of carvedilol phosphate were successfully prepared with improved bioavailability.

    How to Cite this Article
    Madibone M N, Bhokare S G, P B Jadhav. Formulation and Evaluation of Carvedilol Phosphate Sublingual Tablet. Inventi Rapid: Pharm Tech, 2019(2):1-6, 2019.
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