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Inventi Rapid - NDDS

Articles

  • Inventi:pndds/25699/18
    RELEASE MODULATING HYDROPHILIC MATRIX SYSTEMS OF NIFEDIPINE EXTENDED RELEASE TABLETS: OPTIMIZATION OF FORMULATION USING 32 FULL FACTORIAL DESIGN
    Oza Nishant A*, Satyajit Sahoo, Gandhi Pooja

    The objective of the present research work was to systemically device a model of nifedipine extended release tablet and optimization of drug release according to the U.S.P. In this study, the nifedipine extended release tablet were formulated using polymer HPMC K4M and HPMC K100M by wet granulation method and HPMC K4M was also added extra granularly. These formulations were evaluated for the parameters like thickness, hardness, weight variation, drug content uniformity, % friability, in-vitro drug release according to the U.S.P and accelerated stability studies. On the basis of preliminary results, the amount of HPMC K4 M (X1) and and the amount of HPMC K100M (X2) were chosen as independent variables in 32 full factorial design, while % CDR at 4 hours and 12 hours were selected as dependent variables. Multiple linear regression analysis, ANOVA and graphical representation of the influence of factor by contour plots were performed using Design Expert 9. Check point batch was prepared to validate the evolved model. Optimized batch was found to be stable in the stability evaluation.

    How to Cite this Article
    Oza Nishant A, Satyajit Sahoo, Gandhi Pooja. Release Modulating Hydrophilic Matrix Systems of Nifedipine Extended Release Tablets: Optimization of Formulation using 32 Full Factorial Design. Inventi Rapid: NDDS, 2018(3):1-8, 2018.
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