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Inventi Rapid - NDDS

Articles

  • Inventi:pndds/27182/18
    SYSTEMIC ENHANCEMENT OF NEBIVOLOL BY USING NANOSUSPENSION IN-SITU NASAL SPRAY
    Nishant Oza*, Ripal Trivedi, Swati Sagar

    Nebivolol mucoadhesive nasal spray increasing the drug residence time in the nasal cavity and nanosuspension enhance the systemic availability. Nanosuspension was prepared by top down media milling technique by using ZrO2. Nanosuspension was optimized by using various concentrations of stabilizers and various concentrations of ZrO2 beads. Optimized nanosuspension were evaluated for particle size, polydispersivity index, zeta potential, in-vitro dissolution study, residual test, % drug content and stability study. Further various concentrations of gallan gum were added in nanosuspension to prepared in-situ gel. These formulations were evaluated for the parameters like pH, viscosity, gelation capacity, in-vitro diffusion study, % permeation and stability study. Nasal spray was final formulation and it is evaluated for various parameters like spray pattern, droplet size distribution, pH and viscosity. Optimized formulation was subjected to histopathology study. From prepared in-situ gel, batch G4 was selected asoptimized batch. Batch G4 has good gelation capacity, immediate gel formation, remains for extended period, drug release was 93.08%, having a desired viscosity, 5% expansion coefficient, 98.42% drug content, showed permeation 91.2 % into 6 hr and convenient for spraying. Final formulation was nasal spray and it displayed convenient viscosity, pH, spray pattern, droplet size. Histopathology study showed no nasal damage. Study shows that the Optimized batch gives maximum release upto 6 hr.

    How to Cite this Article
    Nishant Oza, Ripal Trivedi, Swati Sagar. Systemic Enhancement of Nebivolol by Using Nanosuspension In-Situ Nasal Spray. Inventi Rapid: NDDS, 2019(1):1-7, 2018.
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