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Inventi Rapid - NDDS

Articles

  • Inventi:pndds/27953/19
    DEVELOPMENT AND EVALUATION OF THIOCOLCHICOSIDE LOADED MICROSPHERES
    More Rutuja K, Patil Moreshwar P, Dhivare Karishma M*, Borase Prashant J, Kshirsagar Sanjay J

    Thiocolchicoside is a semi synthetic drug derived from colchicoside used as a muscle relaxant as well as an anti-inflammatory agent. It has high aqueous solubility and low bioavailability. Hence, the aim of this study was to prolong the release of thiocolchicoside by developing polymeric microspheres. Microspheres were produced by ionotropic gelation technique to prolong the release of thiocolchicoside. Formulations were characterized for particle size and shape, surface morphology, entrapment efficiency and in-vitro drug release. The optimized formulation showed 60.6% entrapment efficiency and 83.18% drug release which was matched with predicted results given by statistical analysis of ANOVA. The microspheres had a porous surface and were found to be discreet and spherical in shape. The particles were heterogeneous with the maximum particles of an average size of 1.112 µm. Fourier transform-infrared spectral analysis and differential scanning calorimetry concluded the absence of any interaction between the drug and the excipients.

    How to Cite this Article
    More Rutuja K, Patil Moreshwar P, Dhivare Karishma M et al. Development and Evaluation of Thiocolchicoside Loaded Microspheres. Inventi Rapid: NDDS, 2019(2):1-6, 2019.
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