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Inventi Rapid - NDDS

Articles

  • Inventi:pndds/28615/19
    FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF TELMISARTAN
    Dalbanjan Nikita*, Vikram Pandya, Dharmesh Golwala

    Research concept was to emphasize mainly on the merits of MDT as it counteracts the demerits of other conventional dosage form, i.e. dysphagia. MDT is a dosage form which disintegrates instantly when placed on tongue, releases the medicament that dissolves/disperses in the saliva. Telmisartan which is a BCS class II anti-hypertensive drug is framed into its sodium salt form, increasing its solubility. The disintegration time is less than 30 seconds and the enhanced solubility makes an attribute that makes this dosage form attractive to the patients. Thus, there is a dual benefit of enhanced solubility as well as benefit of the dosage form. The aim was to formulate MDT highlighting the use of super-disintegrating agents and taste masking agents in formulation by direct compression. Four superdisintegrants were tested, they were sodium starch glycolate (SSG), croscarmellose sodium (CCS), crospovidone (CP) and kyron T-314. The results showed that, formulation PF8 containing crospovidone gave better results compared to other superdisintegrants. Then the formulation PF8 was optimized using Design expert 7.0 by 32 factorial method. From the factorial formulations, FF5 containing silicified microcrystalline cellulose (SMCC, 18.75%) and crospovidone (5%) gave satisfactory results.

    How to Cite this Article
    Dalbanjan Nikita, Vikram Pandya, Dharmesh Golwala. Formulation and Evaluation of Mouth Dissolving Tablets of Telmisartan. Inventi Rapid: NDDS, 2019(3):1-13, 2019.
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