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Inventi Rapid - Pharm Analysis & Quality Assurance

Articles

  • Inventi:ppaqa/27810/18
    ESTIMATION OF DISULFIRAM IN BULK AND FORMULATION BY UV-SPECTROPHOTOMETRIC AREA UNDER CURVE METHOD
    Pachpute Karishma*, Jadhav S L

    The current work was carried out for estimation of disulfiram in bulk and pharmaceutical dosage form by utilizing area under curve (AUC) method. For this purpose the wavelength range 204-230 nm was selected. Methanol was used as a solvent throughout the work. Linearity was observed in concentration range 5-25 µg/ml (r2 = 0.99) for the method. Recovery studies for area under curve were found to be 99.32%. The method developed was validated for linearity, precision, accuracy, LOD, and LOQ as per ICH guidelines. The present method was found to be simple, linear, precise, accurate and sensitive which can be used for routine quality control analysis for spectrophotometric estimation of disulfiram in bulk and dosage form.

    How to Cite this Article
    Pachpute Karishma, Jadhav S L. Estimation of Disulfiram in Bulk and Formulation by UV-Spectrophotometric Area Under Curve Method. Inventi Rapid: Pharm Analysis & Quality Assurance, 2019(2):1-6, 2019.
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