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Inventi Rapid - Pharm Analysis & Quality Assurance

Articles

  • Inventi:ppaqa/27946/19
    AREA UNDER CURVE UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF GLICLAZIDE IN BULK AND FORMULATION
    Pooja Bhore*, S L Jadhav, S M Dhobale

    The article describes a simple, sensitive, rapid, accurate and precise spectrophotometric method for the determination of gliclazide in bulk and pharmaceutical dosage forms by utilizing area under curve (AUC) method. The new method is area under curve method for the analysis of gliclazide using methanol as solvent for the drug. Gliclazide has absorbance maxima at 228.20 nm at area under curve wavelength range of 217.40-236.80 nm. Gliclazide obeys Beer’s law in concentration range 2-10 µg/ml. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.31 µg/ml and 0.92 µg/ml respectively. The percentage recovery of the drug for the proposed method ranged from 98.72-100.5% indicating no interference of the tablet excipients. The method developed was validated for linearity, precision, accuracy, LOD, LOQ as per ICH guidelines. The result demonstrates that proposed method is accurate, precise and reproducible while being simple and rapid too for the determination of gliclazide in tablet dosage form.

    How to Cite this Article
    Pooja Bhore, S L Jadhav, S M Dhobale. Area Under Curve UV Spectrophotometric Method for the Determination of Gliclazide in Bulk and Formulation. Inventi Rapid: Pharm Analysis & Quality Assurance, 2019(2):1-7, 2019.
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