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Inventi Rapid - Med Chem

Articles

  • Inventi:pmc/23430/17
    SYNTHESIZING AN ANTI-OXIDANT PRINCIPLE 2-(((1-METHOXY-9H-CARBAZOL-3-YL)METHYLENE)AMINO)ISOINDOLINE-1,3-DIONE FROM N-AMINOPHTHALIMIDE AND MURRAYANINE
    Debarshi Kar Mahapatra*, Ruchi S Shivhare

    The free radicals, in the form of reactive oxygen species (ROS) such as hydrogen peroxide (H2O2), hydroxyl radical (•OH), superoxide anion (O2-) and reactive nitrogen species (RNS) are unstable molecules containing unpaired electrons that react with biological structures to capture electrons to gain stability. This leads to the initiation of chain reaction causing loss of cellular function. The present research represented an attempt in developing a phthalimide based Schiff’s base compound from murrayanine having impressive and comparable anti-oxidant with that of the standard marketed product or ascorbic acid. The compound was designed rationally and synthesized from the starting material N-aminophthalimide and murrayanine. The structures of synthesized compounds were confirmed by spectroscopic and analytical techniques (IR, 1H-NMR and MS). The free radical scavenging activity of the synthesized analogs was monitored by in-vitro anti-oxidant activity protocol. The experimental data provided a clear judgment that the synthesized data is not a prime candidate due to lower activity (54.76%) than that of ascorbic acid (78.22%) and the parent product murrayanine. However, this attempt may open future avenues of research and guidance in developing anti-oxidant molecules with more pronounced activity.

    How to Cite this Article
    Debarshi Kar Mahapatra, Ruchi S Shivhare. Synthesizing an Anti-Oxidant Principle 2-(((1-methoxy-9H-carbazol-3-yl)methylene)amino)isoindoline -1,3-dione from N-aminophthalimide and Murrayanine. Inventi Rapid: Med Chem, 2017(4):1-3, 2017.
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