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Inventi Rapid - Pharmacokinetics & Pharmacodynamics

Articles

  • Inventi:pkd/99/13
    PHARMACOKINETIC AND SAFETY STUDY OF ASPIRIN SUPPOSITORIES AND ASPIRIN NANOPARTICLES LOADED SUPPOSITORIES
    V Ravi Sankar, D Dachinamoorthi, K B Chandra Shekar

    The main aim and objective of the present work was to study the pharmacokinetic and safety of aspirin suppositories and aspirin nanoparticle loaded suppositories. Aspirin nanoparticles were prepared based on ionicgelation method using sodium tripolyphosphate as cross linking agent. The Prepared nanoparticles were evaluated for characteristic studies and optimized Fa9 formulation was isolated. Aspirin suppositories were prepared using different ration of glycerin and gelatin and evaluated to select the best glycerogelatin base composition based on evaluation tests. Aspirin nanoparticles loaded suppositories were prepared and characterized for various evaluation tests and Fas11 optimized formulation was isolated for pharmacokinetic study. A comparative pharmacokinetic study was performed between aspirin suppositories and aspirin nanoparticle loaded suppositories and evaluated for various pharmacokinetic parameters. The results indicates the increase in Tmax, T1/2, AUC0-t and AUMC0-infinite, MRT in the ASA-nanoparticles loaded suppositories when compared with ASA-suppositories. Histological examination revealed that there was a severe necrosis and ulceration due to continuous use of aspirin suppositories observed within one week thus aspirin nanoparticles loaded suppositories (Fas11) was proved to be safe and effective for long term use.

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