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Inventi Rapid - Pharmacokinetics & Pharmacodynamics

Articles

  • Inventi:pkd/125/14
    PHARMACOSCINTIGRAPHY AND ITS APPLICATIONS: A REVIEW
    Anshul Srivastava, Sateesh Belemkar, Smita C Bonde, Puja Nagpal

    One of the most quick and comprehensive way of determining the in-vivo pharmacokinetic profile is gamma scintigraphic study of labelled bio-medicals, materials and pharmaceuticals with radiation emitting isotopes. The formation of chemical bond between isotope and drug using a chelating agent gives a formulation called as radiopharmaceutical. Binding of two components is radiolabeling. The tagging of radionuclide helps in tracing the bioavailability and bio-distribution study of radiolabelled compound to the target organ. The method adopted in radiolabeling evaluates radiochemical purity by quality control parameter like ITLC which determines the labelling efficiency. Therefore, in nuclear medicine it can be said that higher the labelling efficiency, better the in-vivo evaluation of pharmacokinetic profile of drug. The administration of dosage form tagged with radionuclide can provide vital information about the in-vivo behaviour, extent, rate and site, mode of drug release and morphology of the target organ in animal or human being within the limits of ethical norms.

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