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Inventi Rapid - Novel Excipients

Articles

  • Inventi:pne/17103/15
    DESIGN, OPTIMIZATION AND EVALUATION OF ACECLOFENAC FAST DISSOLVING TABLETS EMPLOYING STARCH BUTYRATE: A NOVEL SUPERDISINTEGRANT
    R Santosh Kumar*, V Kiranmai

    Aceclofenac is non-steroidal anti-inflammatory drug used for the treatment of inflammation and pain caused by rheumatoid arthritis and osteoarthritis. It has a half life of about 4 hrs and is characterized by low solubility and high permeability. It is poorly water soluble drug and when administered orally it may cause bioavailability problems due to its poor solubility and dissolution rates in biological fluids. Hence there is need to enhance the solubility of aceclofenac for rapid therapeutic effect and increased bioavailability. So in the present work was aimed at increasing the rate of dissolution of aceclofenac thus providing faster rate of absorption by adding potential superdisintegrants like novel superdisintegrant starch butyrate and known superdisintegrants like sodium starch glycolate and croscarmellose sodium in different concentrations.

    How to Cite this Article
    R Santosh Kumar, V Kiranmai. Design, Optimization and Evaluation of Aceclofenac Fast Dissolving Tablets Employing Starch Butyrate: A Novel Superdisintegrant. Inventi Rapid: Novel Excipients, 2015(4):1-15, 2015.
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