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Inventi Rapid - Pharmaceutical Process Development

Articles

  • Inventi:ppd/27389/18
    SOLUBILITY ENHANCEMENT OF TINIDAZOLE BY POLOXAMER AND GELUCIRE SOLID DISPERSION
    Sapana Ahirrao, Durgesh Kale, Sarita B Pawar*, Sanjay K Shirsagar

    Low solubility is the major problem reported with various active pharmaceutical ingredients which ultimately affects onset of action and therapeutic profile of that drug. Hence present study focused on solubility enhancement of tinidazole; a widely used antiprotozoal, antiamoebic, antibacterial agent belonging to BCS-II with low solubility and high permeability. Tinidazole solid dispersion prepared with two different polymers: Gelucire 50/13 and Poloxamer 407. Solid dispersion optimised by varying drug-polymer ratio and using different formulation methods like kneading method, solvent evaporation method and fusion method. Formulation batches were characterized by drug content, solubility, in-vitro dissolution, FT-IR (Fourier Transform Infrared) spectroscopy, DSC (Differential scanning calorimetry), XRD (x-ray diffraction) and stability studies. In-vitro dissolution studies revealed that formulation batches Sg14 and Sp14 exhibits faster drug release as compared to other formulation batches. DSC (Differential scanning calorimetry) studies revealed that there was no interaction between drug and carrier whereas the XRD studies of optimised formulation batch demonstrates that there was a significant decrease in crystallinity when compared with XRD pattern of pure drug. Significant change in solubility and in-vitro dissolution rate of tinidazole would be due to amorphous state maintained in the optimised formulation batches. Hence overall formulation and evaluation studies of present research work indicate that optimised solid dispersion is an effective means to improve the solubility of tinidazole.

    How to Cite this Article
    Sapana Ahirrao, Durgesh Kale, Sarita B Pawar et al. Solubility Enhancement of Tinidazole by Poloxamer and Gelucire Solid Dispersion. Inventi Rapid: Pharmaceutical Process Development, 2019(1):1-11, 2018.
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