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Inventi Impact - Nutraceuticals

Patent Watch

  • Lactic acid bacteria and their use in the treatment of cancer

    The invention concerns the isolation of novel properties of lactic acid bacteria stains. Said novel properties are advantageously useful for preventing and treating cancer. More particularly, the invention concerns the use of lactic acid bacteria to facilitate induction of cell apoptosis of a cancer. The invention also concerns the use of lactic acid bacterial strains, such as Lactobacillus acidophilus and Lactobacillus casei in methods and compositions for preventing and treating cancer, in particular colon cancer.

  • High yield method of producing pure rebaudioside A

    The invention provides a high throughput, high purity, high yield system and method of isolating and purifying rebaudioside A ("Reb A"), with acceptable water solubility for all commercial uses, from commercially available Stevia rebaudiana starting material. The invention also provides a means of maximizing yields of 99+% purity Reb A based on the attributes of a given batch of Stevia starting material. The Reb A produced by the invention is water soluble, devoid of bitterness heretofore associated with rebaudioside sweeteners, non-caloric, and suitable for use as a reagent and as an ingredient in orally consumed products, e.g., as a sweetener, flavor enhancer, and flavor modifier.

  • Compositions for alleviating inflammation and oxidative stress in a mammal

    An antioxidant-promoting composition that increases antioxidant defense potential in a subject is disclosed comprising Bacopa monniera extract; milk thistle extract, ashwagandha powder, green tea extract, Gotu kola powder, Ginko biloba leaf extract; Aloe vera powder; turmeric extract; and N-acetyl cysteine. The antioxidant-promoting composition of the invention safely induces cellular antioxidant potential to achieve an overall net decrease in oxidative stress without the undesirable side-effects associated with the individual components of the antioxidant-promoting composition. Also disclosed is a method for reducing the undesirable side-effects of free radicals in a subject by administering to a subject in need of such antioxidants an effective amount of antioxidant-promoting composition of the invention.

  • Composition for high-ORAC value dietary supplement

    A dietary supplement composition having an ORAC value in excess of at least about 2,500 and which can be readily consumed in a small quantity is provided for supplementing an individual's daily intake. The dietary supplement composition suitably includes organic and/or vegan ingredients and can be consumed in quantities of as little as about 1 tablespoon to provide an amount of antioxidants equivalent to at least the minimum recommended daily intake of five to nine servings of fruits and/or vegetables.

  • Steeped cocoa beverages

    The invention provides, in one aspect, a method of producing a cocoa beverage containing beneficial cocoa polyphenols. Ready-to-drink compositions, concentrates, primary beverage components, and packets for producing the beverages are specifically disclosed. Preferred sugar-free, low calorie, and calorie-free products and cocoa beverages are also disclosed.

  • PUFA polyketide synthase systems and uses thereof

    Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

  • Process for producing a stable concentrated dietary supplement and supplement produced thereby

    A process for producing a stable concentrated dietary supplement containing fucoxanthin as the main active component. The method entails grinding crude freeze-dried flakes of wakame seaweed (Undaria pinnatifida) with desirable characteristics into a powder, extracting the active fucoxanthin from the powder with use of an aliphatic or aromatic organic solvent, then filtering and distilling the extract to form a thick syrupy fucoxanthin-containing mass having a solids content of from about 10-99% by wt. The mass is then purified by dissolving it in an organic non-polar solvent having a Polarity Index of <6, wherein the resultant solution is filtered to remove any solid material therefrom and the remaining liquid is then concentrated to a dried mass by removing substantially all of the solvent, which mass is thereafter ground and sifted to obtain a plurality of particles measuring approximately 60-100 mesh in size. The particles contain at least about 10% by weight of fucoxanthin. The particles by themselves, or in admixture with other components well known in the relevant art, thus comprise a supplement which may be constituted in a form selected from, for example, tablets, capsules, powders and granules.

  • Nutritional supplement for treatment of ocular diseases

    A nutritional supplement composition that promotes visual health and reduces or reverses visual acuity loss by a reduced Vitamin E content from standard supplements with the addition of taurine, omega-3 fatty acids, and non proform Vitamin A carotenoids including lutein and zeaxanthin. The essential ingredients of the nutritional or dietary supplements are Vitamin C, no more than 300 IUs of Vitamin E, Vitamin A at least a portion of which is provided in the form of a proform Vitamin A carotenoid, omega-3 fatty acids, and non proform Vitamin A carotenoids including lutein and/or zeaxanthin. The essential ingredients are provided in a form suitable of oral ingestion or other forms of administration in one or more doses per day.

  • Trophic conversion of obligate phototrophic algae through metabolic engineering

    Most microalgae are obligate photoautotrophs and their growth is strictly dependent on the generation of photosynthetically-derived energy. In this study it is shown that the microalga Phaeodaclylurn tricornutum can be engineered to import glucose and grow in the dark through the introduction of genes encoding glucose transporters. Both the human and Chlorella kessleri glucose transporters facilitated the uptake of glucose by P. tricornutum, allowing the cells to metabolize exogenous organic carbon and thrive, independent of light. This is the first successful trophic conversion of an obligate photoautotroph through metabolic engineering, and it demonstrates that methods of cell nourishment can be fundamentally altered with the introduction of a single gene. Since strains transformed with the glucose transport genes are able to grow non-photosynthetically, they can be exploited for the analysis of photosynthetic processes through mutant generation and characterization. Finally, this work also represents critical progress toward large-scale commercial exploitation of obligate phototrophic algae through the use of microbial fermentation technology, eliminating significant limitations resulting from light-dependent growth.

  • Compounds that inhibit (block) bitter taste in composition and use thereof

    The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.

  • Delivery of active agents using a chocolate vehicle

    This invention provides edible compositions comprising pharmaceutically or nutraceutically active agents in particulate form homogeneously dispersed in a fat matrix, such as chocolate or chocolate compound coating.

  • Compositions and methods for preserving cut apples

    This invention is a novel composition for preserving fresh cut apples comprising a mixture of ascorbic acid, and one or more of calcium chloride, calcium carbonate, magnesium chloride, calcium hydroxide, and optionally, citric acid or sodium citrate. This invention also relates to a method of preserving fresh cut apples by treating the cut apples with the novel composition dissolved in water and packaging the treated fresh cut apples in a modified atmosphere package.

  • Maize variety PHEDV

    A novel maize variety designated PHEDV and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PHEDV with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PHEDV through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PHEDV or a trait conversion of PHEDV with another maize variety. Inbred maize varieties derived from maize variety PHEDV, methods for producing other inbred maize varieties derived from maize variety PHEDV and the inbred maize varieties and their parts derived by the use of those methods.

  • Soybean variety XB15M09

    According to the invention, there is provided a novel soybean variety designated XB15M09. This invention thus relates to the seeds of soybean variety XB15M09, to the plants of soybean XB15M09 to plant parts of soybean variety XB15M09 and to methods for producing a soybean plant produced by crossing plants of the soybean variety XB15M09 with another soybean plant, using XB15M09 as either the male or the female parent.

  • Soybean cultivar S07-02JR407076

    The present invention is in the field of soybean cultivar S07-02JR407076 breeding and development. The present invention particularly relates to the soybean cultivar S07-02JR407076 and its progeny, and methods of making S07-02JR407076.

  • Nutrient compositions and methods for enhanced effectiveness of the immune system

    Provided are methods of treating HIV patients by administering to the patient a nutrient composition and at least one anti-retrovial drug. The method results in an increase in the patient's CD4.sup.+ cell count by at least 25% during a treatment period. The nutrient composition includes alpha lipoic acid; acetyl L-carnitine; N-acetyl-cysteine; zinc; selenium; vitamin C; bioflavinoid complex; vitamin E; one or more antioxidants selected from co-enzyme Q10 and glutathione; and one or more vitamins or minerals selected from beta-carotene, vitamin A, vitamin B1, vitamin B2, vitamin B6, niacinamide, calcium pantothenate, folic acid, vitamin B12, copper, manganese, chromium, and molybdenum.

  • Tranquilizer and functional food

    This invention provides a pharmaceutical and functional food which are made of a safe food ingredient or nutrient which has been used for a long period of time, and which have tranquilizing effect such as anti-anxiety effect, anti-depression effect, and anti-stress effect. The tranquilizer of the invention contains vitamin K as an active ingredient. Vitamin K is preferably menaquinone-4 and/or menaquinone-7. This invention also provides a supplement, health food or functional food for tranquilizing purpose that contains vitamin K as an active ingredient.

  • Harvesting method and apparatus for leafy vegetables or legumes

    A harvesting apparatus comprising a first conveyor (30) for conveying seedling trays (10), a cutting station (40) adjacent the first conveyor (30) to cut the leaves of the seedlings and a second conveyor (41) for taking cut leaves away from the cutting station (40). A stationary plate or grill (82) is placed in the gap (82A) between the first conveyor (30) and the cutting station (40) for supporting the trays (10). The cutting mechanism at the cutting station (40) may be adjustable in height above the plate or grill (82). A method of harvesting leafy vegetables and legumes using this apparatus is also described.

  • Soybean cultivar 04KG128257

    The present invention is in the field of soybean cultivar 04KG128257 breeding and development. The present invention particularly relates to the soybean cultivar 04KG128257 and its progeny, and methods of making 04KG128257.

  • Soybean cultivar S07-04KL905009

    The present invention is in the field of soybean variety S07-04KL905009 breeding and development. The present invention particularly relates to the soybean variety S07-04KL905009 and its progeny, and methods of making S07-04KL905009.

  • METHOD AND APPARATUS TO MONITOR, ANALYZE AND OPTIMIZE PHYSIOLOGICAL STATE OF NUTRITION

    A method and apparatus that for monitoring the physiological state of nutrition of an individual and adaptively analyze that data input to anticipate the individual's nutritional needs. A satiety meter may be employed to analyze a user's profile including nutritional state and determine when and how much a user should consume to prevent the onset of hunger and communicate is to a decision engine. The decision engine may generate and communicate a message to the user via the client device to prescribe prophylactic intake of nutrition to the individual prior to the onset of hunger based on the user's nutrition plan and/or regimen.

  • NUTRITIONAL COMPOSITIONS WITH LIPID GLOBULES WITH A CORE COMPRISING VEGETABLE LIPIDS AND A COATING COMPRISING PHOSPHOLIPIDS OR POLAR LIPIDS

    The present invention relates to a nutritional composition for infants and/or toddlers comprising a lipid component which has a large lipid globule size. The composition can be used to prevent obesity and/or improve body composition later in life. Said lipid component comprises 10-50 wt % vegetable lipids, and the lipid globules have a volume-weighted diameter above 1.0 m and/or a diameter of 2-12 m in an amount of at least 45 vol %.

  • FERMENTED SOY NUTRITIONAL SUPPLEMENTS INCLUDING MUSHROOM COMPONENTS

    Dietary, health, and/or nutritional supplements provide various formulations of mushrooms grown in fermented soy, with or without rice flour, optionally in combination with sweetener(s), curcumin, and various other herbs and spices. Certain embodiments or compositions may be in liquid, beverage, solid, paste or powder forms. In certain embodiments the supplements contain mushroom species grown in fermented soy in the presence of certain bacterial species and optionally rice or rice flour. In some embodiments, other ingredients that may be present include one or more of curcumin, desmethoxycurcumin and bis-desmethoxycurcumin or all three curcumins. Certain embodiments may be used to treat or provide symptomatic relief from a variety of maladies ranging from malnutrition to mood related disorders to metabolic support and other more severe conditions as described herein.

  • System and method for determining a nutritional value of a food item

    Computer-implemented method, system, and computer program product for determining a nutritional health value of a food item are disclosed. The method includes receiving information about number of ingredients, controversial ingredients, nutrients and vitamins contained in the food item, assigning a predetermined weighting value to each nutrient contained in the food item. For each nutrient contained in the food item, the method determines a nutrient value based on a percentage of the nutrient contained in the food item and the weighting value of each nutrient contained in the food item. For each vitamin contained in the food item, the method determines a vitamin value based on a sum of percentages of all vitamins contained in the food item. The method further determining an ingredient value based on a total number of ingredients and a total number of controversial ingredients contained in the food item. Then, the method calculates a negative-health-effect value based on a sum of a first set of nutrient values, a positive-health-effect value based on a sum of a second set of nutrient values, a nutrient-to-vitamin value using the calculated negative-health-effect value, the calculated positive-effect-value, and a maximum weight of the calculated positive-effect-value, and a controversial ingredient penalty value. The nutritional health value of the food item is generated using the calculated nutrient-to-vitamin value and the calculated controversial ingredient penalty value.

  • METHOD OF PRODUCING NUTRITIONAL PRODUCTS FROM HUMAN MILK TISSUE AND COMPOSITIONS THEREOF

    Methods of isolating, treating, storing and processing human milk, as well as nutritional formulations of human milk comprising protective human milk proteins.

  • NUTRITIONAL COMPOSITION COMPRISING PROBIOTICS AND IMPROVING SLEEP PATTERNS

    This invention relates to the use of a probiotic bacterial strain in the manufacture of a medicament or therapeutic nutritional composition for improving the maturation of sleep patterns in infants, young children or young animals and/or for reducing sleep disturbances and/or improving sleep patterns in humans or animals at any age.

  • SEMI-SOLID HONEY-BASED PRODUCTS

    Provided are semi-solid honey-based compositions and honey-based products produced therefrom, which can be used, for example, as household sweeteners, candies and/or snacks, and exhibit several consistency variants, such as a soft and spreadable, jelly-like or spoonable product, solid and rubbery handleable product, all designed for rapid dissolution in hot aqueous media, and a snack bar variant having non-soluble, solid food bits such as nuts, fruit bits, cereals and the likes. Also provided are processes of manufacturing the semi-solid honey-based compositions.

  • FORMULATIONS AND METHODS FOR NUTRIENT DELIVERY

    The present disclosure provides formulations and methods for delivering water-soluble and lipid-soluble nutrients for preventing or correcting nutrient deficiencies to subjects requiring small-volume nutritional support, such as preterm infants. The formulations may comprise an emulsion of docosahexaenoic acid (DHA) stabilized by a protein emulsifier, such as .alpha.-lactalbumin, and may further comprise other valuable nutrients, such as arachidonic acid (ARA), arginine, glutamine, arginyl-glutamine dipeptide and/or alanyl-glutamine dipeptide. The formulation is useful, for example, for correcting nutritional deficiencies by increasing a subject's intake of nutrients such as .omega.-3 or .omega.-6 long-chain polyunsaturated acids, proteins, peptides, vitamins, minerals, other fatty acids, and/or essential amino acids. The nutritional formulation is suitable for enteral delivery and small-volume delivery via nasogastric tube, intragastric feeding, transpyloric administration and/or any other means of administration that result in the introduction of the nutritional formulation into the digestive tract of a subject.

  • Non-dairy, non-soy whippable food product and method of making

    A whippable food product and a method of making the same are disclosed. The finished product is packaged by an aseptic packaging process. It is shelf-stable (ingredients do not degrade or segregate during storage) at ambient temperatures for an extended period of time, and it whips stiff to form a uniform creamy topping in a short period of time. The product is free of dairy and animal products/by-products, thus suitable for vegan, kosher, or vegetarian consumption. Also, the product does not contain soy products and/or questionable ingredients such as processed oils or chemical additives, etc.

  • CARDIOPROTECTIVE EFFECTS OF NUTRACEUTICALS ISOLATED FROM NIGELLA SATIVA SEEDS

    This invention relates to a rich antioxidant nutraceuticals prepared from Nigella sativa seeds for the treatment and prevention of hypercholesterolemia. These nutraceuticals when taken enterally has shown successfully to have hypocholesterolmic, antiatherogenic and antioxidant activities using in vitro and in vivo study. The invention provides a clear explanation on the molecular mechanism by which nutraceuticals prepared from the Nigella sativa seeds exerted its hypocholesterolemic effect.

  • PROBIOTIC BACTERIAL MOLECULES AND THEIR USE IN METHODS TO TREAT/PREVENT INFECTION BY HARMFUL BACTERIA AND TO PROVIDE NUTRITIONAL HEALTH

    This invention provides isolated and characterized secreted molecules from probiotic bacteria for use in compositions and methods for the treatment and/or prevention of infection by harmful pathogenic bacteria. The isolated secreted molecules can also be used in nutritional or medical food products which provide probiotics to the gastrointestinal tract of a mammal.

  • PREPARATION FOR USE OF ASPARTATE AND VITAMIN B12 OR BIOTIN FOR REGULATING KETONE BODIES

    It has been found that high amounts of aspartate equivalents in combination with vitamin B12 and/or biotin, especially in relative absence of glutamate equivalents, improve the metabolism of ketobodies and/or lactate in a mammal's body, especially in diseased or traumatic conditions. As a result, levels of ketobodies and lactate can be decreased and unphysicologically high acidity normalised. Thus, it is an object of the invention to provide an enteral nutritional or a pharmaceutical composition for the treatment and/or prevention of disturbed ketone and lactate metabolism, i.e. elevated concentrations of ketone bodies, lactate and/or other organic acids and/or insufficient pH homeostasis, especially elevated concentrations of ketone bodies and/or lactate, in a mammal's blood, wherein the composition comprises high amounts of aspartate equivalents in combination with vitamin B12 and/or biotin, preferably in relative absence of glutamate equivalents.

  • PROCESS FOR PRODUCING INFANT FOOD PRODUCTS

    An UHT asceptic process for producing a range of infant food products comprises at least two steps, wherein, in a first stage, vegetables are cooked and meat or fish is cooked separately from the vegetables to provide pre-cooked ingredients are mixed and submitted to UHT processing at a temperature of about 130.degree. C. to 140.degree. C. for a time of about 30 seconds to about 240 seconds to sterilize the product and filled aseptically into plastics containers.

  • PROCESS FOR UPGRADING LOW VALUE RENEWABLE OILS

    Steps in the processing of oils derived from plants or vegetables include the degumming, deodorizing and bleaching of the oil before it can be used for further applications. By eliminating one or more of these steps from the processing of the oil, followed by hydrogenating the oil to a specified degree of hydrogenation, the resulting upgraded oils can be incorporated into products having commercial applications. The process uses a high shear mixing device and a hydrogenation catalyst. The process can utilize a single or multiple high shear devices, and utilize renewable oils instead of increasingly scarce petroleum based products. The resulting hydrogenated products may then be utilized in a variety of other commercial applications, such as to render cellulosic products water resistant, provide a coating for numerous cellulosic products, adhesive compositions, ink compositions, firelog compositions, drilling muds or asphalt modifiers.

  • DIETARY PURGATIVES

    Described are kits, food compositions and methods for cleaning the bowel, e.g., in preparation for a medical procedure, e.g., a diagnostic or treatment procedure, such as an endoscopic or surgical procedure, or radiologic imaging such as CT colography.

  • HEALTH CHARACTERISTIC DULCE DE LECHE CONFECTION COMPOSITIONS AND FLAVORED MILK

    The present invention provides for Dulce de Leche confection compositions and Dulce de Leche based flavored milk that has an improved, healthier fat structure, unique antioxidant taste profile, lower sugar content, fiber component, and a 0% or greater supplement component that can add additional dietary benefits. Cholesterol reduction can be accomplished within certain embodiments of this invention. Specific ratios of ingredients within our compositions create a taste, texture, mouth feel, and rich and creamy true Dulce de Leche confection without the negative health ramifications of high milk fat content and sugar content characteristic of traditional Dulce de Leche products. Additionally, the method for preparing these Dulce de Leche confection products and flavored milk are covered.

  • NUTRITION COMPOSITION

    The present invention can provide a nutrition composition useful for patients with renal diseases, which has an effective prophylactic or improving effect for various symptoms of malnutrition, inflammation, arteriosclerosis, abnormal lipid metabolism and oxidative stress, associated with renal diseases, or for diabetic nephropathy. The nutrition composition of the present invention m contains one or more kinds of free amino acids selected from the group consisting of valine, leucine, isoleucine and histidine, and a lipid comprising .omega.-3 fatty acid and .omega.-6 fatty acid at a weight ratio (.omega.-6 fatty acid to .omega.-3 fatty acid) of 0.5-5.5. In addition, the composition further contains a soybean protein or a hydrolysate thereof together with the aforementioned lipid or instead of the aforementioned lipid.

  • DIETARY SUPPLEMENTS CONTAINING EXTRACTS OF CINNAMON AND METHODS OF USING SAME TO ENHANCE CREATINE TRANSPORT

    Materials derived from cinnamon can be administered orally to humans or animals for the purpose of controlling blood glucose as well improving glucose tolerance. Controlling glucose metabolism is essential for those with impaired glucose metabolism as is the case for those with Type II diabetes where insulin function is not properly functioning. Such administration can also be used for the purpose of enhancing nutrient transport for purposes of athletic performance and controlling bodyweight and body fat levels. Similarly related, such administration can also be used for the purpose of enhancing creatine transport into excitable tissues such as skeletal muscle. The material can be administered as extracts of cinnamon and can be administered in a variety of ways including capsules, tablets, powdered beverages, bars, gels or drinks.

  • Single Daily Dosage Form for Prevention and Treatment of Metabolic Syndrome

    The present invention is in the fields of medicine, pharmaceuticals, nutraceuticals, endocrinology and cardiology. The invention provides compositions comprising a statin, an inhibitor of the angiotensin converting enzyme, an antiplatelet compound and an anti-hyperglycemic compound for use in the treatment and/or prevention of cardiometabolic risk factors of Metabolic Syndrome and treatment and/or prevention of Metabolic Syndrome. The present invention provides for the use of such compositions in the manufacture of products for treatment and/or prevention of Metabolic Syndrome. The biguanide metformin of the composition could be present in extended release form allowing its use together with the other drugs in a single dosage form at low dose. This combination of drugs in a single daily dosage greatly improves compliance and adherence to treatment which is a critical factor for treating patients with Metabolic Syndrome.

  • Combination Dosage Compositions Comprising a Cholesterol-Lowering Agent, a Renin-Angiotensin System Inhibitor, an Antioxidant Agent and an Antiplatelet Agent for Treatment and Prevention of Cardiovascular Disease

    The present invention is in the fields of medicine, pharmaceuticals, nutraceuticals and cardiology. The invention provides compositions comprising a statin, an inhibitor of the angiotensin converting enzyme, an antiplatelet compound and an antioxidant compound for the treatment and/or prevention of cardiovascular disease.

  • CHOCOLATE DELIVERY SYSTEM FOR LIVE MICROORGANISMS

    A chewable composition for the oral delivery of live microorganisms is provided. The chewable composition includes a delivery vehicle and an active ingredient incorporated therein. The delivery vehicle may include a chocolate candy. The active ingredient may include a predetermined amount of at least one probiotic. The delivery vehicle may also include a predetermined amount of at least one prebiotic. The delivery vehicle may also include any combination of nutraceuticals, vitamins, minerals, antioxidants, soluble and insoluble fiber, herbs, plants, probiotics, prebiotics, antioxidants, amino acids, fatty acids, digestive enzymes, dietary supplements, or any other health promoting ingredient.

  • CHEWABLE SUPPLEMENT WITH LIVE MICROORGANISMS

    A chewable composition for the oral delivery of live microorganisms is provided. The chewable composition includes a delivery vehicle and an active ingredient incorporated therein. The delivery vehicle may include an organic or non-organic gummy candy including a binding agent, sweetener, flavoring, and/or coloring. The active ingredient may include a predetermined amount of at least one probiotic. The delivery vehicle may also include a predetermined amount of at least one prebiotic. The delivery vehicle may also include any combination of nutraceuticals, vitamins, minerals, antioxidants, soluble and insoluble fiber, herbs, plants, probiotics, prebiotics, antioxidants, amino acids, fatty acids, digestive enzymes, dietary supplements, or any other health promoting ingredient.

  • IMPROVED EMULSIFYING SYSTEM FOR NUTRACEUTICAL COMPOSITIONS

    The inventive composition allows the solubilization of hydrophobic nutraceuticals in water to produce clear and stable solutions. The hydrophobic nutraceutical is combined with a lecithin and optionally other components to form an oil. Sucrose is dissolved in water and combined with hydrophilic cosolvents. Sucrose fatty acid ester emulsifier is dissolved in the sucrose-cosolvent mixture. The nutraceutical oil is homogenized into the sucrose ester emulsifier solution to form a stable homogenate that can be readily dispersed into an aqueous solution.

  • PLANT EXTRACTS FROM ACRONYCHIA SPECIES AND THEIR USE

    The invention relates to plant extracts and bioactive molecules derived from the plant genus Acronychia and their use as antioxidants, antibacterials, anthelmintic, anti-inflammatories, cancer chemopreventatives, food additives and fragrance components in pharmaceuticals, nutraceuticals, foods and cosmetics.

  • PREPARATION AND METHODOLOGY OF SILK FIBROIN NANOPARTICLES

    Disclosed are nanoparticles for delivery of drugs and/or nutraceuticals that include a fibroin polypeptide and a drug or nutraceutical, wherein the nanoparticle has a diameter of about 1 nm to about 500 nm, and compositions of the nanoparticles. The nanoparticles may further include a chitosan, or a proteoglycan such as decorin. Also disclosed are methods of delivering a drug and/or nutraceutical to a subject that involve administering to the subject nanoparticles of the present invention. Also disclosed are methods of making the nanoparticles of the invention, and kits that include the nanoparticles of the invention.

  • SECURE CONTAINERS HAVING UNIDIRECTIONAL APPARATUSES FOR USED OR UNUSED MATERIALS AND METHODS FOR MAKING AND USING SAME

    Secure containers are disclosed for disposal of unused, experimental, and/or expired pharmaceuticals, nutraceuticals, veterinary medicines, and/or similar materials, where the containers include at least one unidirectional apparatus for depositing materials into an interior of the container, while resisting normal attempts at retrieval of deposited materials. Methods are also disclosed for making and using the secure containers including a unidirectional member supporting deposition of materials into an interior of the container, while resisting withdrawal of deposited materials.

  • TRANSGENIC PLANTS USED AS A BIOREACTOR SYSTEM

    The present invention relates generally to the use of plants as bioreactors for the production of molecules having useful properties such as inter alia polymers, metabolites, proteins, pharmaceuticals and nutraceuticals. More particularly, the present invention contemplates the use of grasses, and even more particularly C4 grasses, such as sugarcane, for the production of a range of compounds such as, for example, polyhydroxyalkanoates, pHBA, vanillin, indigo, adipic acid, 2-phenylethanol, 1,3-propanediol, sorbitol, fructan polymers and lactic acid as well as other products including, inter alia, other plastics, silks, carbohydrates, therapeutic and nutraceutic proteins and antibodies. The present invention further extends to transgenic plants and, in particular, transgenic C4 grass plants, capable of producing the compounds noted above and other products, and to methods for generating such plants. The ability to utilize the high growth rate and efficient carbon fixation of C4 grasses is advantageous, in that it obviates the significant growth penalties observed in other plants, and results in high yields of desired product without necessarily causing concomitant deleterious effects on individual plants. In addition, the C4 grass, sugarcane, is particularly advantageous, as in addition to the features common to all C4 grasses, this plant accumulates sucrose. This sucrose store provides a ready supply of carbon based compounds and energy which may further obviate any deleterious effects on the growth of the plant associated with the production of the product. The present invention provides, therefore, a bioreactor system comprising a genetically modified plant designed to produce particular metabolic or biosynthetic products of interest.

  • CARDIOPROTECTIVE EFFECTS OF NUTRACEUTICALS ISOLATED FROM NIGELLA SATIVA SEEDS

    This invention relates to a rich antioxidant nutraceuticals prepared from Nigella sativa seeds for the treatment and prevention of hypercholesterolemia. These nutraceuticals when taken enterally has shown successfully to have hypocholesterolmic, antiatherogenic and antioxidant activities using in vitro and in vivo study. The invention provides a clear explanation on the molecular mechanism by which nutraceuticals prepared from the Nigella sativa seeds exerted its hypocholesterolemic effect.

  • METHODS AND COMPOSITIONS FOR IMPROVING IMMUNE RESPONSE BY A NUTRACEUTICAL ANTIOXIDANT

    The present invention provides a new means of restoring the immune system in aging and immunocompromised individuals using an antioxidant nutraceutical. Thenutraceutical stimulates the aging immune system through the Nrf2 master gene regulatory pathway. The invention is based in part on the discovery that the Nrf2 has antioxidant and immune restorative activity. The nutraceutical improves function of both the innate and adaptive immune systems.

  • COMPOSITION FOR REGULATING LIPID METABOLISM

    This invention concerns a nutraceutical and/or food composition for regulating, among other things, lipid metabolism in humans and animals, and methods of use of said nutraceutical and/or food composition.

  • INDUCIBLE RELEASE VEHICLES

    This invention relates to inducible release vehicle comprised of crosslinked carbohydrates or proteins and an active ingredient. The release is induced by an external stimulus, e.g. an enzyme such as amylase. Such a vehicle can particularly be used in an applications for preventing microbial decay or combating microbial infections. Other uses are for oral applications such as providing anti-caries or flavoring compounds and for pharmaceutical and/or nutraceutical applications.

  • PEPTIDE AVAILABILITY

    The present invention provides a process for producing a composition which is preferably a food, food intermediate, dietary supplement, feed or pet food, which comprises mixing together a peptide mixture, comprising a bioactive peptide, and a protein source having a protein quality (expressed as PER) of 2.4 or lower. The composition of the invention can be used to improve the bioavailability of bioactive peptides or used as a food, food intermediate, nutraceutical, dietary supplement, feed, or pet food.

  • USE OF EXTRACTS OF PEZIZACEAE IN THE PREVENTION AND/OR TREATMENT OF SENILE CATARACTS

    The invention provides methods for treating and/or preventing the recurrence of a senile cataract, and/or for inhibiting the development of a senile cataract and/or an incipient senile cataract, in a human or animal subject. The invention further provides nutraceutical compositions suited for the same, derived from an extract of truffles (Pezizaceae). The compositions comprise the extract in a therapeutically sufficient amount for the treatment and/or prophylaxis of a senile cataract in a human and/or animal subject.

  • PHARMACEUTICAL AND NUTRACEUTICAL COMPOSITIONS FOR TREATING RESPIRATORY DISEASE AND ASSOCIATED PHLEGM

    The present invention relates to pharmaceutical compositions comprising dextromethorphan or a physiologically acceptable salt thereof, quercetin, resveratrol, and hesperidin. The invention further relates to nutraceutical or dietary supplement composition comprising a physiologically acceptable salt of magnesium, quercetin, resveratrol, and hesperidin. Further provided are methods for treating respiratory disease in a human subject by substantially eliminating phlegm from the lung through administering to the subject effective amounts of compositions of the invention.

  • Nutraceutical Composition and Methods for Preventing or Treating Multiple Sclerosis

    The present invention embraces nutraceutical compositions containing isolated Bacteroides fragilis capsular polysaccharide A for use in methods of preventing or treating multiple sclerosis.

  • GASTRIC RESISTANT PHARMACEUTICAL OR NUTRACEUTICAL FORMULATION COMPRISING ONE OR MORE SALTS OF ALGINIC ACID

    The invention relates to a gastric resistant pharmaceutical or nutraceutical composition, comprising a core, comprising a pharmaceutical or nutraceutical active ingredient and a gastric resistant coating layer onto the core, wherein the release of the pharmaceutical or nutraceutical active ingredient is not more than 15% under in-vitro conditions at pH 1.2 for 2 hours in medium according to USP with and without the addition of 40% (v/v) ethanol, wherein the gastric resistant coating layer comprises 10 to 100% by weight of one or more salts of alginic acid with a viscosity of 30 to 720 cP of a 1% aqueous solution

  • PHARMACEUTICAL AND NUTRACEUTICAL COMPOSITIONS OF ABSCISIC ACID

    The invention relates to compositions comprising abscisic acid, and/or salts, derivatives and analogs thereof, and methods of pharmaceutical and/or nutraceutical use.

  • COSMETIC COMPOSITION FOR THE TREATMENT OF ACNE COMPRISING A PEPTIDE EXTRACT OF SCHIZANDRA

    The present invention relates to a cosmetic, nutraceutical or dermatological composition for treating or preventing acne, comprising a peptide and oside extract of Schizandra fruit and a suitable excipient. Preferably, the extract is obtained from Schizandra sphenanthera. The composition may also comprise at least one anti-acne agent selected from a sebum-regulating agent, an antibacterial and/or antifungal agent, a keratolytic agent and/or a keratoregulating agent, an astringent, an anti-inflammatory and/or anti-irritant, an antioxidant and/or a free-radical scavenger, a cicatrizing agent, an anti-ageing agent and a moisturizing agent. The invention also relates to a method for cosmetic treatment of acne, characterized in that a cosmetic composition according to the invention is applied to the affected areas of the skin, or in that the affected individual takes a nutraceutical composition according to the invention orally.

  • FUNCTIONAL FORMULATION IN CHEWING GUM

    Nutraceutical gum or functional food compositions comprise Ashwagandha (Withania somnifera) and L-theanine in a sublingual formulation. Methods of making suitable sublingual formulations are described. Also provided is a method for reduction of stress and/or enhancement of energy and mental clarity, comprising administering to an individual in need thereof an effective amount of a nutritional composition comprising Ashwagandha herb and L-theanine, and a nutraceutically acceptable carrier, wherein the nutritional composition is administered sublingually.

  • COMPOSITION OF EXTRACT OF EMBLICA OFFICINALIS AND METHOD OF PREPARING THE SAME

    The present disclosure relates to a composition of an extract of fruits of Emblica officinalis selected from the group consisting of liquid juice of fruits of Emblica officinalis, a powder of an alcoholic extract of fruits of Emblica officinalis, a powder of a hydro alcoholic extract of fruits of Emblica officinalis, a powder of a water extract of fruits of Emblica officinalis, a powder of a juice of fruits of Emblica officinalis, a powder of dried fruits of Emblica officinalis, a powder of a water extract of dried fruits of Emblica officinalis, a powder of a pectinase treated water extract of fruits of Emblica officinalis, and combinations thereof; a method of preparing such compositions of extract of fruits of Emblica officinalis, more particularly which has application as a nutraceutical or pharmaceutical for increasing HDL-C levels in patients with memory loss and dementia especially in patients with neurodegenerative diseases like Alzheimer's disease and for the treatment of memory loss especially in Alzheimer's disease.

  • Nutraceutical Composition and Methods for Preventing or Treating Multiple Sclerosis

    The present invention embraces nutraceutical compositions containing isolated Bacteroides fragilis capsular polysaccharide A for use in methods of preventing or treating multiple sclerosis.

  • AQUEOUS CARBONATED MEDIUM CONTAINING AN AMINO(METH)ACRYLATE POLYMER OR COPOLYMER

    The invention relates to an aqueous medium containing an amino(meth)acrylate polymer or copolymer which is not soluble in demineralised water, characterized in that the medium has a content of an aqueous phase of at least 60% by weight and a content of up to 40% by weight of solids comprising the amino(meth)acrylate polymer or copolymer, whereby the aqueous phase is charged by a sufficient amount of carbon dioxide that effects the amino(meth)acrylate polymer or copolymer to be present in solute form in the medium. The aqueous medium may be used beneficially as a coating or binding solution for the spray coating or binding of pharmaceutical compositions or nutraceutical compositions or cosmetical compositions.

  • PHARMACEUTICAL AND NUTRACEUTICAL COMPOSITIONS OF ABSCISIC ACID

    The invention relates to compositions comprising abscisic acid, and/or salts, derivatives and analogs thereof, and methods of pharmaceutical and/or nutraceuticaluse.

  • ALKYLSACCHARIDE COMPOSITIONS WITH NUTRACEUTICALS

    The present invention provides nutraceutical compositions with enhanced oral bioavailability. The compositions of the present invention include one or more alkylsaccharides admixed with one or more nutraceutical.

  • METHOD AND APPARATUS FOR PACKAGING AND DELIVERING NUTRACEUTICAL, PHARMACEUTICAL, AND POLYCEUTICAL COMPOSITIONS

    This invention relates to methods and apparatus for bottling/packaging orally ingested compositions, said method comprising compounds of nutraceutical, pharmaceutical, or polyceutical components, collectively unique combinations of liquid and solid elements such as pills and capsules. These can be nutraceuticals, pharmaceuticals, or polyceuticals for improving cardiovascular health. Said apparatus comprises a container having a conventional closure with an additional detachable base member. This packaging configuration divides the container into two chambers; the superior or upper chamber and the inferior or lower chamber. In one embodiment the upper chamber is designed to contain liquid compounds, whereas the lower detachable chamber is designed to contain solid matters such as pills and capsules. In one form of this invention the upper and lower chambers are attached to each other by a latching mechanism. Also, in one form of this invention, the interior portion of the lower chamber is partitioned into several smaller units.

  • NUTRACEUTICAL BEVERAGE

    A nutraceutical composition for humans and/or animals containing three main components: water, aloe, and a plant mineral and/or sea mineral complex is provided. The composition provides a 100 percent, all natural, plant derived, completely organic, dietary supplement beverage that is indistinguishable from plain water in clarity, odor, taste and mouthfeel. This formulation supplies a synergy of naturally occurring, bioactive phytonutrients that the body requires, including a combination of macronutrients and micronutrients, e.g.: water, carbohydrates, proteins, lipids, vitamins, minerals, enzymes and antioxidants. This phytosynergistic formulation is designed to fuel cellular hydration, enhance nutrient absorption, promote toxin elimination, improve energy, stamina, digestive health, muscle performance and recovery, and overall health and wellness. This formulation has a negative oxidation reduction potential, which helps to reduce cellular damage and aging caused by free radicals. This formulation has an alkalizing potential to shift the body's pH away from acidification and disease formation

  • Methods and systems for analysis of nutraceutical associated components

    The present disclosure relates to methods and systems that may be used for analysis of nutraceutical associated components.

  • METHOD FOR PRODUCING A NUTRACEUTICAL COMPOSITION AND THE NUTRACEUTICAL PRODUCED BY THE METHOD

    A method for producing a nutraceutical composition comprising a combination of oil soluble antioxidants derived from an edible oil and water soluble antioxidants derived from a plant extract, wherein the plant extract further provides a natural surfactant; and the nutraceutical composition produced by that method.

  • NUTRITIONALLY ENHANCED FRACTION FROM RICE BRAN AND METHOD OF LOWERING INSULIN RESISTANCE USING SAME

    Nutritionally enhanced nutraceutical Hydrophilic and Lipophilic Rice Bran Fractions from rice bran are provided, as well as a method of using the same to reduce Insulin Resistance in animals, especially humans with pre-diabetes and Type 2 diabetes or others with symptoms of Metabolic Syndrome. Provided in various example embodiments are mixtures of elevated levels of nutraceutical compounds, including but not limited to gamma-oryzanol, inositol, ferulic acid, tocotrienols and phytosterols and pharmaceutical and nutritional compositions thereof. Steps are provided including evaluating insulin resistance parameters, initiating therapy including providing therapeutic amounts of Hydrophilic and Lipophilic Rice Bran Fractions from rice bran to treat pre-diabetes and Type 2 diabetes or others with symptoms of Metabolic Syndrome, managing compliance with the therapy, and monitoring and reevaluating the therapy.

  • CLERODANE DERIVATIVES FOR MODULATION OF LEUKOTRIENE RECEPTOR ACTIVITY AND RELATED DISEASES

    The use or methods of use of extracts comprising one or more special clerodane compounds against inflammatory (including allergic) diseases or conditions, as well as novel compounds of this type, said clerodane derivatives for use against inflammatory (including allergic) diseases or conditions, pharmaceutical formulations comprising them especially for use against inflammatory disease or conditions, and related embodiments; said extract and/or compound(s) for use in the treatment or in the preparation of a medicament (including a nutraceutical) for the prophylactic and/or therapeutic treatment of said disease or condition, as well as their preparation; pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in said prophylactic and/or therapeutic treatment, and related embodiments.

  • NIGELLA EXTRACTS FOR THE TREATMENT OF SYMPTOMS CONNECTED TO IMPAIRED OR IMBALANCED NEUROTRANSMISSION

    The present invention relates to the use of Nigella sp. extracts and their volatile components for the treatment of symptoms connected to impaired neurotransmission in animals including humans as well as to dietary supplements, food and feed or nutraceutical compositions containing such extracts or their volatile components.

  • ACACIA MACROSTACHYA SEED EXTRACT AND COMPOSITIONS CONTAINING SAME

    The invention relates to a composition containing an extract of seeds of Acacia macrostachya. Advantageously the composition is cosmetic, pharmaceutical, dermatological or nutraceutical. The invention also relates to a method for extracting a Acacia macrostachya seed extract, as well as to the resulting extract. The invention further relates to one such composition or one such extract for use in the prevention or treatment of disorders and diseases affecting the skin, mucosae or appendages, for use in the prevention or treatment of vascular disorders and for use in the prevention or treatment of adipose tissue alterations. Moreover, the invention relates to a method for cosmetic care of the Skin, appendages and mucosae in order to improve the condition or appearance thereof, comprising the administration of one such composition or one such extract.

  • SCHISANDRA SPHENANTHERA FRUIT EXTRACT AND COSMETIC, DERMATOLOGICAL AND NUTRACEUTICAL COMPOSITIONS COMPRISING SAME

    The present invention relates to a cosmetic, dermatological or nutraceutical composition comprising a Schisandra sphenanthera fruit extract. Said Schisandra sphenanthera fruit extract is selected from a peptide and sugar extract, a crude oil, a refined oil, a refined oil concentrate or the unsaponifiable fraction of said concentrate. The invention also relates to a method for preparing a peptide and sugar extract, a refined oil, and a concentrate and an unsaponifiable fraction of oil of Schisandra sphenanthera fruit. Finally, the invention relates to the dermatological, cosmetic and nutraceutical uses of said extracts.

  • PHARMACEUTICAL AND NUTRACEUTICAL COMPOSITIONS FOR TREATING RESPIRATORY DISEASE AND ASSOCIATED PHLEGM

    The present invention relates to pharmaceutical compositions comprising dextromethorphan or a physiologically acceptable salt thereof, quercetin, resveratrol, and hesperidin. The invention further relates to nutraceutical or dietary supplement composition comprising a physiologically acceptable salt of magnesium, quercetin, resveratrol, and hesperidin. Further provided are methods for treating respiratory disease in a human subject by substantially eliminating phlegm from the lung through administering to the subject effective amounts of compositions of the invention.

  • NUTRACEUTICAL COMPOSITION THAT COMPRISES EXTRACT OF SHILAJIT, FOLIC ACID, VITAMIN B12 AND VITAMIN B6 AND THE USE THEREOF FOR PREVENTING AND/OR TREATING NEURODEGENERATIVE DISEASES AND/OR THE COGNITIVE DETERIORATION ASSOCIATED WITH CEREBRAL AGEING

    The present invention relates to a potent antioxidant neuroprotective nutraceutical composition that comprises blending extract of Shilajit (250 to 500 mg) and folic acid (200 to 400 .mu.g), together with small amounts of vitamins B6 (20 to 40 .mu.g) and B12 (4 to 8 .mu.g) consumed per day. This composition can be used to prevent and to treat neurodegenerative diseases or episodes of cognitive deterioration arising from various pathological conditions. The use thereof is indicated in the treatment of Alzheimer's disease and senile dementia as the pathological conditions preferably to be treated. The composition is suitable for direct human consumption by mouth, either in solid form as a powder or as a suspension of the extract, as a food additive or as a nutraceutical agent. It may be formulated as a nutraceutical agent to be included as an ingredient in beverages or as a drug in conjunction with permitted excipients.

  • METHOD AND APPARATUS FOR PACKAGING AND DELIVERING NUTRACEUTICAL, PHARMACEUTICAL, AND POLYCEUTICAL COMPOSITIONS

    This invention relates to methods and apparatus for bottling/packaging orally ingested compositions, said method comprising compounds of nutraceutical, pharmaceutical, or polyceutical components, collectively unique combinations of liquid and solid elements such as pills and capsules. These can be nutraceuticals, pharmaceuticals, or polyceuticals for improving cardiovascular health. Said apparatus comprises a container having a conventional closure with an additional detachable base member. This packaging configuration divides the container into two chambers; the superior or upper chamber and the inferior or lower chamber. In one embodiment the upper chamber is designed to contain liquid compounds, whereas the lower detachable chamber is designed to contain solid matters such as pills and capsules. In one form of this invention the upper and lower chambers are attached to each other by a latching mechanism. Also, in one form of this invention, the interior portion of the lower chamber is partitioned into several smaller units.

  • TRANS-, TRANS-CONJUGATED LINOLEIC ACID COMPOSITIONS AND USE THEREOF

    This invention relates generally to trans-,trans-conjugated linoleic acid compositions and use thereof, and in particular to trans-,trans-conjugated linoleic acid produced from photoisomerization of soy oil in the presence of an antioxidant, and used in pharmaceutical, nutraceutical and human and animal food compositions for improved health. The invention also relates generally to a method for treatment and prevention of health-related disorders of obesity by administration of pharmaceutical, nutraceutical and/or food compositions containing and/or prepared from trans-,trans-conjugated linoleic acid-rich soy oil.

  • CHROMAN-DERIVED ANTI-ANDROGENS FOR TREATMENT OF ANDROGEN MEDIATED DISORDERS

    Methods for the prevention and/or alleviation of androgen-mediated disorders treatable by administering a chroman-derived anti-androgen compound are provided by the present invention. The invention further provides pharmaceutical and nutraceutical compositions containing chroman-derived anti-androgen compounds useful in the prevention and/or alleviation of androgen-mediated disorders, particularly prostate cancer.

  • Enzymatic Production or Chemical Synthesis and Uses for 5,7-Dienes and UVB Conversion Products Thereof

    Provided herein are steroidal compounds that are androsta-5,7-dienes or pregna-5,7-dienes and ultraviolet B (UVB) conversion products thereof and cholecalciferol derivatives hydroxylated at one or more of C1, C17, C20, C23, C24, C25, and C26 which includes pharmaceutical, cosmeceutical or nutraceutical compositions of the steroidal compounds as shown in Tables 1A, 2A and 3. Also provided is a method for producing hydroxylated metabolites of cholecalciferol via CYP11A1, CYP24, CYP27A1, or CYP27B1 enzyme systems where the hydroxylase has an activity to hydroxylate position C1 or C20 or other position of the sidechain of a secosteroid or its 5,7-dieneal precursor and the hydroxylated metabolites so produced. Methods are provided for inhibiting proliferation of either a normally or abnormally proliferating cell, for modifying immune activity, or for treating a condition associated with the proliferating or quiescent cell or immune cells by contacting the cell with or administering any of the compounds described herein.

  • Nutritionally Enhanced Fraction From Rice Bran And Method of Lowering Insulin Resistance Using Same

    Nutritionally enhanced nutraceutical Hydrophilic and Lipophilic Rice Bran Fractions from rice bran are provided, as well as a method of using the same to reduce Insulin Resistance in animals, especially humans with pre-diabetes and Type 2 diabetes or others with symptoms of Metabolic Syndrome. Provided in various example embodiments are mixtures of elevated levels of nutraceutical compounds, including but not limited to gamma-oryzanol, inositol, ferulic acid, tocotrienols and phytosterols and pharmaceutical and nutritional compositions thereof. Steps are provided including evaluating insulin resistance parameters, initiating therapy including providing therapeutic amounts of Hydrophilic and Lipophilic Rice Bran Fractions from rice bran to treat pre-diabetes and Type 2 diabetes or others with symptoms of Metabolic Syndrome, managing compliance with the therapy, and monitoring and reevaluating the therapy.

  • METHOD AND APPARATUS FOR PACKAGING AND DELIVERING NUTRACEUTICAL, PHARMACEUTICAL, AND POLYCEUTICAL COMPOSITIONS

    This invention relates to methods and apparatus for bottling/packaging orally ingested compositions, said method comprising compounds of nutraceutical, pharmaceutical, or polyceutical components, collectively unique combinations of liquid and solid elements such as pills and capsules. These can be nutraceuticals, pharmaceuticals, or polyceuticals for improving cardiovascular health. Said apparatus comprises a container having a conventional closure with an additional detachable base member. This packaging configuration divides the container into two chambers; the superior or upper chamber and the inferior or lower chamber. In one embodiment the upper chamber is designed to contain liquid compounds, whereas the lower detachable chamber is designed to contain solid matters such as pills and capsules. In one form of this invention the upper and lower chambers are attached to each other by a latching mechanism. Also, in one form of this invention, the interior portion of the lower chamber is partitioned into several smaller units.

  • METHOD AND APPARATUS FOR PACKAGING AND DELIVERING NUTRACEUTICAL, PHARMACEUTICAL, AND POLYCEUTICAL COMPOSITIONS

    This invention relates to methods and apparatus for bottling/packaging orally ingested compositions, said method comprising compounds of nutraceutical, pharmaceutical, or polyceutical components, collectively unique combinations of liquid and solid elements such as pills and capsules. These can be nutraceuticals, pharmaceuticals, or polyceuticals for improving cardiovascular health. Said apparatus comprises a container having a conventional closure with an additional detachable base member. This packaging configuration divides the container into two chambers; the superior or upper chamber and the inferior or lower chamber. In one embodiment the upper chamber is designed to contain liquid compounds, whereas the lower detachable chamber is designed to contain solid matters such as pills and capsules. In one form of this invention the upper and lower chambers are attached to each other by a latching mechanism. Also, in one form of this invention, the interior portion of the lower chamber is partitioned into several smaller units.

  • NIGELLA EXTRACTS FOR THE TREATMENT OF SYMPTOMS CONNECTED TO IMPAIRED OR IMBALANCED NEUROTRANSMISSION

    The present invention relates to the use of Nigella sp. extracts and their volatile components for the treatment of symptoms connected to impaired neurotransmission in animals including humans as well as to dietary supplements, food and feed or nutraceutical compositions containing such extracts or their volatile components.

  • ACACIA MACROSTACHYA SEED EXTRACT AND COMPOSITIONS CONTAINING SAME

    The invention relates to a composition containing an extract of seeds of Acacia macrostachya. Advantageously the composition is cosmetic, pharmaceutical, dermatological or nutraceutical. The invention also relates to a method for extracting a Acacia macrostachya seed extract, as well as to the resulting extract. The invention further relates to one such composition or one such extract for use in the prevention or treatment of disorders and diseases affecting the skin, mucosae or appendages, for use in the prevention or treatment of vascular disorders and for use in the prevention or treatment of adipose tissue alterations. Moreover, the invention relates to a method for cosmetic care of the Skin, appendages and mucosae in order to improve the condition or appearance thereof, comprising the administration of one such composition or one such extract.

  • VIGNA UNGUICULATA SEED EXTRACT AND COMPOSITIONS CONTAINING SAME

    The invention relates to a composition comprising a Vigna unguiculata seed extract. The composition is advantageously cosmetic, pharmaceutical, dermatological or nutraceutical. The invention further relates to a method for extracting a Vigna unguiculata seed extract, as well as to the resulting extract. The invention further relates to one such composition or one such extract for use in the prevention or treatment of disorders or pathologies of the skin, mucosae or appendages, for use in the prevention or treatment of vascular disorders, or for use in the prevention or treatment of adipose tissue alterations. Finally, the invention relates to a method for cosmetic care of the skin, appendages or mucosae, in order to improve the condition or appearance thereof, comprising the administration of one such composition or one such extract.

  • COMPOSITIONS AND METHODS COMPRISING C16:1n7-PALMITOLEATE

    One embodiment described herein is related to methods and compositions, such as nutraceutical formulations and dietary supplements, comprising C16:1n7-palmitoleate or derivatives thereof. The methods and compositions comprising C16:1n7-palmitoleate, or derivatives thereof, safely and effectively prevent or mitigate manifestations of cardiovascular disease, including coronary artery disease and the accumulation of cholesterol or lipid deposits in the blood vessels of a subject.

  • METHODS FOR THE BIOSYNTHESIS OF TAURINE OR HYPOTAURINE IN CELLS

    The present invention describes an approach to increase taurine or hypotaurine production in prokaryotes or eukaryotes. More particularly, the invention relates to genetic transformation of organisms with genes that encode proteins that catalyze the conversion of cysteine to taurine, methionine to taurine, cysteamine to taurine, or alanine to taurine. The invention describes methods for the use of polynucleotides that encode functional cysteine dioxygenase (CDO), cysteine dioxygenase (CDO) and sulfinoalanine decarboxylase (SAD) or glutamate decarboxylase (GAD), cysteamine dioxygenase (ADO), taurine-pyruvate aminotransferase (TPAT), TPAT and sulfoacetaldehyde acetyltransferase (SA), taurine dioxygenase (TDO) or the small (ssTDeHase) and large subunits of taurine dehydrogenase (lsTDeHase) polypeptides in plants to increase taurine, hypotaurine or taurine precursor production. The preferred embodiment of the invention is in plants but other organisms may be used. Increased taurine production in plants will enhance plant growth and development, yield, or tolerance to biotic and/or abiotic stresses and could be used as nutraceutical, pharmaceutical, or therapeutic compounds or as a supplement in animal feed.

  • METHODS OF PRODUCING AND USING NUTRITIONAL AND PHARMACEUTICAL COMPOSITIONS THAT INCLUDE ONE OR MORE ACTIVE SUBSTANCES

    Methods for producing a composition that includes an active agent, nutraceutical and pharmaceuticals compositions, and methods for ameliorating and/or treating a disease using the composition that includes an active substance are described herein. More particularly, methods for producing a composition that contains one or more active substances such as oleocanthal, pharmaceutical compositions that include one or more active substances such as oleocanthal, and methods of ameliorating and/or treating inflammation using compositions that contains one or more active substances such as oleocanthal are described.

  • FUSION POLYPEPTIDES AND USES THEREOF

    The invention relates to fusion polypeptides comprising a polynucleotide-binding domain, such as a DNA-binding domain, and a ligase domain, such as a DNA ligase domain, methods for the production of such fusion polypeptides, and uses of the fusion polypeptides, for example in a range of molecular biological techniques as well as applications in the diagnostics, protein production, pharmaceutical, nutraceutical and medical fields.

  • CALCIUM CARBONATE GRANULATION

    Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.

  • SPECIAL COMPOSITION FOR THE USE THEREOF AS A DRUG

    The present invention relates to a composition containing at least one polyphenol, at least one polyethylene glycol and/or a functional equivalent and at least one glycol ether and/or a functional equivalent for application as a medicinal product. The composition according to the invention can also be used as a food supplement or nutraceutical.

  • COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING DISEASES AND ENVIRONMENTALLY INDUCED HEALTH DISORDERS

    Nutraceutical or pharmaceutical compositions, functional foods, extracts, dietary supplements and food/feed additives enriched in phytochemicals having antioxidant and/or anti-inflammatory activity may be derived from the skin, pith, or cortex from stem tubers of select potato cultivars, including an Onaway potato cultivar optionally complemented by a Russet Burbank, Purple Valley or Bora Valley cultivar. These cultivars and combinations thereof provide a useful antioxidant source enriched in ferulic acid, caffeic acid, chlorogenic acids, ascorbic acid, anthocyanins, and rutin, isomers or derivatives thereof having antioxidant and/or anti-inflammatory activity.

  • METHOD FOR SYNTHESIZING CALIXARENE AND/OR CYCLODEXTRIN COPOLYMERS, TERPOLYMERS AND TETRAPOLYMERS, AND USES THEREOF

    The present invention relates to a novel method for synthesizing a composition of polymers, copolymers, terpolymers and tetrapolymers, and to the use thereof, said composition being made from: cyclodextrins, in particular .alpha.-cyclodextrin, .beta.-cyclodextrin, .gamma.-cyclodextrin, the derivatives thereof or the corresponding mixtures thereof; and/or calix[n]arene(s) and/or calix[n]arene derivative(s) and/or a mixture of two or more different calix[n]arenes selected from calix[n]arenes (n=4-20) and/or the derivatives thereof, and to the uses thereof. A method was developed on the basis of bulk polycondensation by heating. The invention can be used in the pharmaceutical, human medicine, veterinary medicine, chemistry, separation chemistry, environmental, electronics, biology, diagnostics, phytosanitation, medicinal food, agri-food, and cosmetics fields, and in the nutraceutical field and in the field of molecular imprints (MIP).

  • ORALLY BIOAVAILABLE STILBENOIDS- COMPOSITIONS AND THERAPEUTIC APPLICATIONS THEREOF

    A novel, bioavailable and safe stilbenoid 3,5-dimethoxy-3,4'-dihydroxystilbene represented by SIR#1 with an unexpected enhanced ability to prevent the accumulation of lipids accompanying the terminal differentiation of adipocytes, thereby inhibiting adipogenesis, and nutraceutical and cosmeceutical compositions comprising, dimethoxy-3,4'-dihydroxystilbene useful for anti-obesity and anti-cellulite therapy, are disclosed. Further the enhanced SIRT-1 activation ability of 3,5-dimethoxy-3,4'-dihydroxystilbene represented by STR#1 and 2,3',5',6-tetrahydroxy-trans-stilbene represented by STR#II are disclosed. The enhancement of SIRT-1 polypeptide activity of the said compounds is unexpectedly much higher than resveratrol or its natural analog pterostilbene. Sirtuin modulating compositions comprising an orally bioavailable SIRT-1 enhancing compounds (i) 3,5-dimethoxy-3,4'-dihydroxystilbene represented by STR#I and (ii) 2,3',5',6-tetrahydroxy-trans-stilbene represented by are also disclosed. An additional embodiment, also discloses the enhanced anti-Propionibacterium acnes activity of 3,5-dimethoxy-3,4'-dihydroxystilbenes represented by STR#I and compositions thereof. ##STR00001##

  • METHOD FOR SYNTHESIZING CALIXARENE AND/OR CYCLODEXTRIN COPOLYMERS, TERPOLYMERS AND TETRAPOLYMERS, AND USES THEREOF

    A method synthesizes a composition of polymers, copolymers, terpolymers and tetrapolymers. The composition may be made by combining in a reaction chamber, a crosslinking agent and one or more of a calix[n]arene, cyclodextrin, a mixture of a plurality of calix[n]arenes, different cyclodextrins, derivatives of calix[n]arenes, and derivatives of cyclodextrins, stirring the mixture, making a solid residue using microwaves, washing the solid residue, drying some of the wash, filtering some of the wash, and drying the resulting filtered solution. The composition may include alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin, the derivatives or corresponding mixtures thereof, and/or calix[n]arene(s) and/or of calix[n]arene derivative(s) and/or a mixture of two or more different calix[n]arenes selected from calix[n]arenes (n=4-20) and/or the derivatives thereof. The method has application to pharmaceuticals, human medicine, veterinary medicine, chemistry, separation chemistry, environmental, electronics, biological, diagnostics, phytosanitation, medicinal food, agri-food, cosmetics, thenutraceutical field, and in the field of molecular imprints (MIP).

  • HYDROXYTYROSOL COMPOSITIONS FOR TREATMENT OF CARTILAGE INJURIES IN JOINTS

    The invention relates to the use of hydroxytyrosol for inducing or enhancing cartilage repair or cartilage regeneration. Furthermore, the invention relates to nutraceutical and pharmaceutical compositions comprising hydroxytyrosol for regeneration and repair of cartilage injuries in joints, in particular of traumatic cartilage injuries.

  • FORMULATION FOR RELIEF OF COLD AND FLU SYMPTOMS

    A nutritional composition or functional food composition is provided comprising homeopathic ingredients for relieving the symptoms of colds and/or flus, in combination with traditional herbal and nutraceutical ingredients, and are efficacious as antipathogens. The formulation includes ingredients balanced in a synergistic manner to elicit complementary effects which both reduce the symptoms of colds and/or flus and provide the potential to reduce pathogenic loads in the body. Methods of making both the core medicinal formulation and suitable dietary supplement and/or functional food embodiments based on the formulation are provided.

  • COMPOSITION CONTAINING RESVERATROL AND/OR DERIVATIVES THEREOF AND PLANT OIL, PROCESS FOR PRODUCING SAID COMPOSITION, NUTRACEUTICAL AND/OR PHARMACEUTICAL PRODUCT, AND METHOD FOR ENHANCING THE POTENTIAL OF RESVERATROL

    The present invention is a method for obtaining a formulation of resveratrol and rice bran oil. The resulting product in the form of an oil or solid proves to increase the therapeutic potential of resveratrol by the synergistic action of the components of the rice oil. The product obtained through the method of the invention is an active principle which, when incorporated in nutraceutical and/or pharmaceutical compositions, provides antioxidant, anti-inflammatory, antiviral, cardioprotective, neuroprotective and/or cancer chemoprotective action, besides protecting against infections and ischemia, reducing obesity, and preventing illnesses of old age.

  • NANOCRYSTALS AND AMORPHOUS NANOPARTICLES AND METHOD FOR PRODUCTION OF THE SAME BY A LOW ENERGY PROCESS

    A process for the production of nanocrystals or amorphous nanoparticles of actives (nanomaterials), especially from the peels of grapes. A dispersion of a micrometer-sized material in a solution of surfactant or a steric stabilizer is first provided. The macrosuspension is then stirred for at least 1 minute at a rotational speed above 500 rpm using a rotor-stator mixer. The stirred mixture is passed through a jet stream or piston-gas type high pressure homogenizer. The nanomaterials produced can be incorporated into formulations for use as nutraceutical, nutritional supplement, or as supportive treatment in medical therapy. The active can be derived from the peels of grapes.

  • CANNABINOID FORMULATIONS

    The present invention provides stable, fast-acting liposomal and micelle formulations of cannabinoids that are suitable for pharmaceutical and nutraceutical applications.

  • Novel Method For Delivery and Use of Isothiocyanates For Prophylaxis and/or Therapy of Bladder Cancer

    Provided is a composition that contains a mixture of broccoli seed and mustard seed. Before mixing the broccoli seed with the mustard seed, the broccoli seed is subjected to baking and a pressurized heat treatment. The broccoli seed is baked at a temperature of at least 200 degrees Fahrenheit for at least 60 minutes, and is subjected to a pressurized heat treatment of at least 200 degrees Fahrenheit at a pressure of at least 10 pounds/square inch for at least 5 minutes. Also provided is a method for therapy and/or prophylaxis of bladder cancer in an individual. The method entails administering orally to the individual a composition that contains an isothiocyanate (ITC) or a derivative thereof such that the administration inhibits the growth and/or recurrence of bladder cancer. Nutraceutical compositions are also provided.

  • ENCAPSULATION OF EXTRACT IN POROUS PARTICLES

    A process in which the extract of an extraction process, such as a supercritical fluid extraction process, such as a fugitive extract and particularly an ingestible extract, is recovered by depositing the extract within the pores of a porous particle that is suitable for direct use as a food additive, or as a nutraceutical.

  • FORMULATION FOR ALLEVIATION OF KIDNEY STONE AND GALLSTONE SYMPTOMS

    A nutraceutical formula and food-based medicinal composition is provided comprising homeopathic ingredients in combination with traditional herbal and nutraceutical ingredients for relieving the symptoms associated with presence or formation of kidney stones and gallstones. The formulation includes ingredients balanced in a synergistic manner to elicit complementary effects which both reduce the symptoms of kidney stones and gallstones and provide the potential to eliminate their occurrence in the body and prevent future recurrence. Methods of making and using core medicinal formulations and food-based compositions are also described.

  • COMPOSITION FOR MUCOSALLY DELIVERING FRUIT CELL CULTURES AND/OR PREPARATIONS DERIVED THEREFROM AND METHODS OF USING SAME

    A pharmaceutical or nutraceutical composition comprising a cell line callus culture of grape berry cells grown in vitro, whereby the cell line callus culture of grape berry cells is derived from one or more of grape-berry cross section, grape-berry skin, grape-berry flesh, grape seed, grape embryo of seeded or seedless cultivars or grape seed coat.

  • HYDROXYTYROSOL BENEFITS MUSCLE DIFFERENTIATION AND MUSCLE CONTRACTION AND RELAXATION

    This invention is related to the use of hydroxytyrosol ("HT"), or an olive juice extract containing hydroxytyrosol as an agent to improve muscle differentiation and thus improve or maintain the body's adaptation to exercise. It is also related to the use of hydroxytyrosol ("HT"), or an olive juice extract containing hydroxytyrosol as an agent to improve calcium signaling and to improve skeletal muscle contraction and relaxation. It also relates to pharmaceutical and nutraceutical compositions useful for conditions characterized by altered muscle differentiation especially under inflammatory conditions, such as delayed onset muscle soreness subsequent to strenuous exercise or sarcopenia.

  • PROCESS FOR THE PREPARATION OF CALCIUM SALT SUSPENSIONS

    The current invention is related to a novel process for the production of aqueous suspensions of micro and nanoparticles of calcium salts smaller than 10 .mu.m particle size, along with a method to enrich nutritional,nutraceutical, and pharmaceutical beverages with calcium salts. In the process, an aqueous suspension of calcium salt is subjected to pressurization with critical, subcritical, or supercritical carbon dioxide to increase the solubility of the calcium salt, which has a particle size greater than 30 .mu.m. The resulting solution is expanded through a nozzle to generate a calcium salt suspension of micro and nanoparticles that is imperceptible to sight and taste.

  • SUGAR PLANT DERIVED BY-PRODUCTS AND METHODS OF PRODUCTION THEREOF

    The present document describes a nutraceutical or cosmeceutical composition for the prophylaxis of an ailment comprising a therapeutically effective amount of a sugar plant syrup filtration residue in association with a pharmaceutically acceptable carrier. The present document also describes a nutraceutical or cosmeceutical composition for improving health condition of skin. The present document describes a method of producing a sugar plant syrup-derived product; wherein the improvement is characterized in the step of: collecting a sugar plant syrup residue during the production of sugar or syrup to produce a syrup-derived by-product.

  • COMPOSITION FOR PERINATAL AND NEONATAL STROKE

    The present invention relates to a novel, non-toxic, prophylactic maternal nutraceutical composition for prevention, treatment, minimization or amelioration of brain damage from perinatal and/or neonatal stroke.

  • Neuroprotective Natural Extract from Passion Fruit

    Methods for the treatment and prevention of neural cell and neuro-pathological disorders are provided, comprising contacting the neural cells, or administering to a subject in need thereof, botanical raw material (BRM) or an extract obtainable from passion fruits. Compositions, as well as a nutraceutical composition comprising the same are also provided.

  • Apple Skin Extracts for Treating Cardiovascular Disease

    Pharmaceutical and nutraceutical compositions and methods for treating cardiovascular disease, comprising apple skin extracts which can reduce cholesterol levels and inhibit low density lipoprotein (LDL) oxidation in a subject, are provided.

  • Calcium Carbonate Granulation

    Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.

  • COATED NUTRACEUTICAL AND PHARMACEUTICAL COMPOSITIONS

    This invention provides oral nutraceutical or pharmaceutical compositions comprising a physiologically tolerable capsule provided with a chewing or bubble gum coat (preferably a chewing gum coat) and containing a physiologically tolerable lipid.

  • ORAL VETERINARY PHARMACEUTICAL AND NUTRACEUTICAL COMPOSITIONS

    This invention provides an oral veterinary pharmaceutical or nutraceutical composition comprising a physiologically tolerable gelled oil-in-water emulsion further comprising at least one component selected from taste enhancers, odour enhancers, digestive enzymes and veterinary drugs.

  • NUTRACEUTICAL CHOCOLATE OR COMPOUND CHOCOLATE PRODUCT

    The subject invention relates to a chocolate or compound chocolate product comprising added functional ingredients including vitamin C, vitamin E, zinc, copper and, optionally, a xanthophyll. The invention further concerns the production of such chocolates and compound chocolate products, their assembly in kit formats and the use of these products for the therapy of diseases of the eye, in particular macular degeneration and cataract formation, or for the maintenance and support of general eye health.

  • COMPOSITION COMPRISING A COMBINATION OF AT LEAST ONE PROTEOLYTIC ENZYME AND AT LEAST ONE LIPOLYTIC ENZYME, FOR USE IN PREVENTING TRIGLYCERIDE SYNTHESIS

    The present invention relates to a composition comprising a combination of at least one proteolytic enzyme, such as subtilisin, and at least one lipolytic enzyme, for use in preventing triglyceride synthesis, advantageously by degrading 2-monoacylglycerol in the intestine. The invention also has as an object such a composition for use as a drug, cosmetic agent, medical device, dietary composition, dietary supplement or nutraceutical, notably for use in preventing or treating obesity, atherosclerosis, type 2 diabetes or for use in preventing or reducing excess weight.

  • COMPOSITIONS CONTAINING AS THE ACTIVE INGREDIENT COMPONENTS FROM SALVIA SCLAREA SEED

    The present invention concerns a food supplement comprising Salvia sclarea seeds, or flour, oil or pulp or extracts obtained from the seeds as well as finished food products comprising the food supplement. The present invention further concerns a nutraceutical or cosmetic preparation comprising as an active ingredient Salvia sclarea seeds, or flour, oil or pulp or extracts obtained from the seeds.

  • DIHYDROCHALCONE PURIFICATION PROCESS

    The present invention relates to an improved process for the preparation of an extract enriched in dihydrochalcones, and more specifically enriched in phlorizin, starting from a polyphenolic fraction originating from industrial apple processing. The invention also relates to a dihydrochal-cone extract obtainable by this process, and to a food or a nutraceutical product comprising a dihydrochalcone extract of the present invention.

  • AVOCADO FLESH AND/OR SKIN EXTRACT RICH IN POLYPHENOLS AND COSMETIC, DERMATOLOGICAL AND NUTRACEUTICAL COMPOSITIONS COMPRISING SAME

    The invention relates to an avocado extract rich in polyphenols, containing at least 10% by weight of polyphenols, expressed in gallic acid equivalent relative to the dry extract obtained, wherein said polyphenols contain procyanidins, cafeic acid and cafeic acid derivatives, typically in a proportion of at least 70% by weight, expressed in gallic acid equivalent relative to the total polyphenol content by weight. The invention also relates to a composition comprising an extract according to the invention as active agent and a suitable excipient. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths. Finally, the invention relates to a cosmetic care process for the skin, the superficial body growths or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which consists in administering such a composition or such an extract.

  • BARLEY PROTEIN MICROCAPSULES

    The invention is directed to microcapsules, pharmaceutical or nutraceutical compositions comprising same, and methods for preparing and using same for delivery of nanoparticle coated emulsions comprising biologically active ingredients. The microcapsule comprises barley protein, oil, and a biologically active ingredient. The microcapsule is degradable to generate a nanoparticle comprising an oil droplet coated with a barley protein.

  • Method for Producing Probiotically Derived Compounds

    A method for producing naturally derived beneficial compounds including dispersing a microbiological culture media including at least one live probiotic organism, and at least one nutraceutical and/or at least one nutritive agent in distilled water to form a broth, incubating the broth at a predetermined temperature for a select period of time to induce probiotic activity; halting the probiotic activity, and separating the desired compound from the broth.

  • SILENE CAPENSIS FOR INHIBITING CRAVINGS

    A composition can include: silene extract; and a carrier having the silene extract. The composition can include an active agent, such as a pharmaceutical or a nutraceutical. The composition can be in a form of a solid, paste, gel, gum, or combination thereof. The carrier can facilitate retention in the mouth, chewing, sucking, holding in the lip next to the gums, or other non-liquid format. A method can provide an alternative to an activity that reduces desire to perform the activity, the method can include: administering to a subject in need thereof the composition having silene. The method can include administering the composition in an effective amount to treat one or more of smoking dependence, tobacco withdrawal symptoms, and tobacco dependence in the subject, wherein the activity is smoking.

  • USE OF A STANDARDISED DRY EXTRACT OF LEAVES OF BUDDLEJA GLOBOSA HOPE, BG-126, FOR THE TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS CAUSED BY TREATMENT WITH NITROFURANTOIN AND OTHER ANTIMICROBIALS

    The invention relates to the use of a composition comprising extract of Buddleja globosa Hope and pharmacologically accepted excipients for the preparation of a phyto-pharmaceutical agent, a drug or a nutraceutical for the prevention of gastrointestinal disorders, particularly those associated with treatment with nitrofurantoin or gastric disorders produced by ulcers, gastric diseases or damage to the gastrointestinal tract. The aforementioned disorders can correspond to abdominal pain, dyspepsia, nausea, vomiting, diarrhea, constipation, inflammation and cephalalgia resulting from treatment with nitrofurantoin and other antimicrobials. In addition, the extract and the compositions thereof can be used to enhance the antibacterial action of nitrofurantoin, particularly against Escherichia coli.

  • NGNA COMPOSITIONS AND METHODS OF USE

    The present invention relates to the field of viral disorders, and in particular to viral obesity. Compositions comprising nutraceutical agents are provided for treating viral obesity. Additionally, compositions comprisingnutraceutical agents targeting adenoviruses are provided.

  • Hydroxylated Polymethoxyflavone Compositions

    Provided herein are compositions enriched in polyhydroxylated polymethoxyflavones useful as dietary supplements, food additives, pharmaceutical compositions, nutraceutical compositions and cosmetic compositions.

  • CHROMAN-DERIVED ANTI-ANDROGENS FOR TREATMENT OF ANDROGEN MEDIATED DISORDERS

    Methods for the prevention and/or alleviation of androgen-mediated disorders treatable by administering a chroman-derived anti-androgen compound are provided by the present invention. The invention further provides pharmaceutical and nutraceutical compositions containing chroman-derived anti-androgen compounds useful in the prevention and/or alleviation of androgen-mediated disorders, particularly prostate cancer.