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Inventi Impact - Biomedical Engineering

Patent Watch

  • Preprocessing for cardiac mapping

    A non-contact cardiac mapping method is disclosed that includes: (i) inserting a catheter into a heart cavity having an endocardium surface, the catheter including multiple, spatially distributed electrodes; (ii) measuring signals at the catheter electrodes in response to electrical activity in the heart cavity with the catheter spaced from the endocardium surface; and (iii) determining physiological information at multiple locations of the endocardium surface based on the measured signals and positions of the electrodes with respect to the endocardium surface. Related systems and computer programs are also disclosed.

  • High resolution optical coherence tomography based imaging for intraluminal and interstitial use implemented with a reduced form factor

    Mechanically robust minimal form factor OCT probes suitable for medical applications such as needle biopsy, intraluminal and intravascular imaging are achieved in part by employing compound lenses with some or all of the optical elements, including an optical fiber, to be thermally fused in tandem. To achieve a desired working distance without increasing a diameter of the optics assembly, a spacer can be disposed between the optical fiber and focusing optics. The compound lens configuration can achieve higher transverse resolution compared to a single lens at a desired working distance without increasing the probe diameter. In exemplary needle biopsy embodiments, the optical assembly is encapsulated in a glass housing or metal-like housing with a glass window, which is then selectively passed through a hollow needle. Esophageal imaging embodiments are combined with a balloon catheter. Circumferential and three-dimensional spiral scanning can be achieved in each embodiment.

  • Feedback enhanced plasma spray tool

    An improved automatic feedback control scheme enhances plasma spraying of powdered material through reduction of process variability and providing better ability to engineer coating structure. The present inventors discovered that controlling centroid position of the spatial distribution along with other output parameters, such as particle temperature, particle velocity, and molten mass flux rate, vastly increases control over the sprayed coating structure, including vertical and horizontal cracks, voids, and porosity. It also allows improved control over graded layers or compositionally varying layers of material, reduces variations, including variation in coating thickness, and allows increasing deposition rate. Various measurement and system control schemes are provided.

  • Method for non-invasive cancerous tissue diagnosis and tomography using terahertz imaging

    The primary objective of the present method and apparatus is to provide a portable and new diagnosis system for quickly and reliably examining tissue conditions. The method uses the most advance miniaturized micro-opto-electro-mechanical systems (MOEMS) for generating a rapid variable optical delay line capable of generating wideband terahertz pulses. The method detects and analyzes cancerous tissues by comparing a plurality of spectrum resolved images of suspected tissue without applying harmful agents into the tissue to facilitate interaction with illumination sources. The method employs non-evasive, real time terahertz imaging systems and techniques to diagnose tissue for detecting the presence of cancer. A map showing, which tissue is healthy and which is cancerous can aid in the accurate removal of cancerous tissue.

  • Biodegradable polyketal polymers and methods for their formation and use

    The present invention relates to biodegradable biocompatible polyketals, methods for their preparation, and methods for treating animals by administration of biodegradable biocompatible polyketals. In one aspect, a method for forming the biodegradable biocompatible polyketals comprises combining a glycol-specific oxidizing agent with a polysaccharide to form an aldehyde intermediate, which is combined with a reducing agent to form the biodegradable biocompatible polyketal. The resultant biodegradable biocompatible polyketals can be chemically modified to incorporate additional hydrophilic moieties. A method for treating animals includes the administration of the biodegradable biocompatible polyketal in which biologically active compounds or diagnostic labels can be disposed. The present invention also relates to chiral polyketals, methods for their preparation, and methods for use in chromatographic applications, specifically in chiral separations. A method for forming the chiral polyketals comprises combining a glycol-specific oxidizing agent with a polysaccharide to form an aldehyde intermediate, which is combined with a suitable reagent to form the chiral polyketal. A method for use in chiral separations includes the incorporation of the chiral polyketals in the mobile phase during a chromatographic separation, or into chiral stationary phases such as gels. The present invention further relates to chiral polyketals as a source for chiral compounds, and methods for generating such chiral compounds.

  • Fluorescent proteins and chromoproteins from non-Aequorea hydrozoa species and methods for using same

    The present invention provides nucleic acid molecules encoding a fluorescent and chromo-proteins and mutants, variants and derivatives thereof, as well as proteins and peptides encoded by these nucleic acids. The nucleic acid molecules and proteins of interest are isolated from non-Aequorea Hydrozoa species. The proteins of interest include yellow fluorescent protein, phiYFP, from Phialidium sp., green fluorescent protein hydr1GFP and purple chromoprotein, hm2CP from hydroid medusae of sub-order Anthomedusae. Also of interest are proteins that are substantially similar to, or derivatives, or homologues, or mutants of, the above-referenced specific proteins. Also provided are fragments of the nucleic acids and the peptides encoded thereby, as well as antibodies specific to the proteins and peptides of the invention. In addition, host-cells, stable cell lines and transgenic organisms comprising above-referenced nucleic acid molecules are provided. The subject protein and nucleic acid compositions find use in a variety of different applications and methods, particularly for labeling of biomolecules, cell or cell organelles. Finally, kits for use in such methods and applications are provided.

  • Laser based metal deposition (LBMD) of antimicrobials to implant surfaces

    A method is provided for depositing a hard wear resistant surface onto a porous or non-porous base material of a medical implant. The wear resistant surface of the medical implant device may be formed by a Laser Based Metal Deposition (LBMD) method such as Laser Engineered Net Shaping (LENS). The wear resistant surface may include a blend of multiple different biocompatible materials. Further, functionally graded layers of biocompatible materials may be used to form the wear resistant surface. Usage of a porous material for the base may promote bone ingrowth to allow the implant to fuse strongly with the bone of a host patient. The hard wear resistant surface provides device longevity, particularly when applied to bearing surfaces such as artificial joint bearing surfaces or a dental implant bearing surfaces. An antimicrobial material such as silver may be deposited in combination with a metal to form an antimicrobial surface deposit.

  • Fetal ECG monitoring

    A method for fetal monitoring includes acquiring electrical signals from a set of electrodes, for example, a set of surface electrodes applied to a maternal abdominal region. The electrical signals are analyzed, including by performing a morphological analysis of fetal electrocardiogram signals. A clinical indicator is then determined from a result of performing the morphological analysis.

  • Implantable microdevice with extended lead and remote electrode

    An implantable microdevice includes at least one electrode detachably connected to electronic circuitry housed in an hermetically-sealed micro housing. The micro housing has a length no more than about 10 mm. In one embodiment, the electrode is located at a distal end of an electrode lead, and a proximal end of the electrode lead is removably inserted into a connector that forms part of the micro housing.

  • Systems and methods for analyzing and manipulating biological samples

    A system for qualifying cells of a cell sample labeled with a magnetic or magnetizable moiety is provided. The system includes a cell sample holder for holding a cell of the cells and a first cell analyzer which includes a magnetic field source for applying a magnetic field to the cell and a sensor for qualifying and/or quantifying an effect of the magnetic field on the cell.

  • Microfluidic gradient devices

    The present invention relates to devices and systems that may generate and maintain a chemical gradient. In one embodiment, the invention provides a source and a sink channel so that a gradient bridge is created. In another embodiment, the gradient bridge creates a stable environment for facilitating molecular events to occur, such as a cell migration, or formation of crystallized molecules.

  • CHAIN EXTENDERS

    The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering. The chain extenders comprise a compound of formula.(I) ##STR00001##

  • COMPUTATIONAL METHODS AND COMPOSITIONS

    The invention in some aspects relates to methods, devices and compositions for evaluating material properties, such as mechanical and rheological properties of substances, particularly biological substances, such as cells, tissues, and biological fluids. In some aspects, the invention relates to methods, devices and compositions for evaluating material properties of deformable objects, such as cells. In further aspects, the invention relates to methods, devices and compositions for diagnosing and/or characterizing disease based on material properties of biological cells.

  • Electroprocessed Collagen and Tissue Engineering

    The invention is directed to formation and use of electroprocessed collagen, including use as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed collagen may also be combined with other molecules in order to deliver substances to the site of application or implantation of the electroprocessed collagen. The collagen or collagen/cell suspension is electrodeposited onto a substrate to form tissues and organs.

  • Dual sided processing and devices based on freestanding nitride and zinc oxide films

    Thin freestanding nitride films are used as a growth substrate to enhance the optical, electrical, mechanical and mobility of nitride based devices and to enable the use of thick transparent conductive oxides. Optoelectronic devices such as LEDs, laser diodes, solar cells, biomedical devices, thermoelectrics, and other optoelectronic devices may be fabricated on the freestanding nitride films. The refractive index of the freestanding nitride films can be controlled via alloy composition. Light guiding or light extraction optical elements may be formed based on freestanding nitride films with or without layers. Dual sided processing is enabled by use of these freestanding nitride films. This enables more efficient output for light emitting devices and more efficient energy conversion for solar cells.

  • EXTENDED INTERIOR METHODS AND SYSTEMS FOR SPECTRAL, OPTICAL, AND PHOTOACOUSTIC IMAGING

    The present invention relates to the field of medical imaging. More particularly, embodiments of the invention relate to methods, systems, and devices for imaging, including for tomography-based applications. Embodiments of the invention include, for example, a computed tomography based imaging system comprising: (a) at least one wide-beam gray-scale imaging chain capable of performing a global scan of an object and acquiring projection data relating to the object; (b) at least one narrow-beam true-color imaging chain capable of performing a spectral interior scan of a region of interest (ROI) of and acquiring projection data relating to the object; (c) a processing module operably configured for: (1) receiving the projection data; (2) reconstructing the ROI into an image by analyzing the data with a color interior tomography algorithm, aided by an individualized gray-scale reconstruction of an entire field of view (FOV), including the ROI; and (d) a processor for executing the processing module. The extended interior methods and systems for spectral, optical, and photoacoustic imaging presented in this application can lead to better medical diagnoses by providing images with higher resolution or quality, and can lead to safer procedures by providing systems capable of reducing a patient's exposure time to, and thus quantity of, potentially harmful x-rays. Embodiments of the invention also provide tools for real-time tomography-based analyses.

  • MAGNETIC NANOSTRUCTURED PROPELLERS

    This invention describes methods and systems for the fabrication and application of Magnetically Actuated Propellers (MAPs). MAPs are structures with typical feature sizes in the range of 20 nanometers up to 100 microns in one spatial dimension. MAPs are propellers that can be obtained from nano-structured surfaces and that can be produced in large numbers. MAPs are propelled and controlled by magnetic fields. The biomedical, surgical, therapeutic, diagnostic, and rheological applications of the fabricated MAPs are also disclosed. The MAPs described in this patent are optimized for low Reynolds number propulsion and can be moved in fluids and biological tissues. MAPs are useful for measurements, quantification, imaging and sensing purposes e.g. detecting biomolecules and for the controlled transportation of (drug- and bio-) molecules and the delivery of microscopic and nanoscale objects and/or materials or systems of therapeutic value.

  • RAPID AND EFFICIENT ASSAY TO ASSESS THE SEQUENCE AND SIZE OF 3' ENDS OF POLYNUCLEOTIDES

    Described herein is an efficient, highly reproducible approach to assess poly(A) tail length on a mRNA specific basis. The embodiments herein have led to the development of a versatile, easy to use kit for biomedical researchers to address the impact of changes in poly(A) tail length in the post-transcriptional regulation of gene expression.

  • Biomedical devices

    Biomedical devices such as contact lenses formed from a polymerization product of a mixture comprising an ethylenically unsaturated-containing non-amphiphilic macromonomer comprising hydrophilic units or hydrophobic units derived from a living radical polymerization of one or more ethylenically unsaturated hydrophilic monomers or one or more ethylenically unsaturated hydrophobic monomers are disclosed.

  • Surface modified biomedical devices

    A method for making a surface modified biomedical device is disclosed, the method comprising contacting a surface of a biomedical device with a copolymer which is the reaction product of one or more polymerizable polyhydric alcohols and one or more polymerizable fluorine-containing monomers.

  • Casting mold for forming a biomedical device including an ophthalmic device

    A casting mold is provided for forming a biomedical device including an ophthalmic device such as a contact lens. The casting mold includes an anterior mold section and a posterior mold section, wherein one of the mold sections includes a plurality of radially extending ribs and the remaining mold section includes an annular shoulder for engaging an outer end of the ribs to define a mold cavity.

  • Managing biological databases

    Methods and systems for managing biological databases. The methods and systems can comprise creation, organization, and presentation of biological databases. The biological databases can be created using data obtained from a plurality of other databases and periodically updated. An executive summary can be created for a biological sequence using the biological database.

  • Method, apparatus, and program product for creating an index into a database of complex molecules

    The disclosed technology relates to the creation of creating an indexing system. The indexing system is created by selecting a macromolecule structure and determining a reference mass and an adjacent ion mass. The reference mass and the adjacent ion mass associated with the macromolecule structure are then stored in the indexing system.

  • Method and apparatus for noninvasively monitoring parameters of a region of interest in a human body

    Apparatus and methods including a probe device for monitoring a parameter of a region of interest in a human body. A support structure of the device carries an arrangement of light output ports of a light source assembly, light input ports of a light detection assembly, and an acoustic output port of an acoustic unit. The arrangement is such as to enable selection of a light output port, a light input port, and an acoustic output port for an operating condition at which, acoustic waves from the acoustic output port and illuminating light from the light output port overlap in a region within the region of interest in the body thereby inducing tagging of light by the acoustic waves, and the light input port collects light scattered from the overlapping region and light scattered from outside the region of interest. Other embodiments are also described.

  • Magnetic induction devices and methods for producing them

    A magnetic induction device (MID) is disclosed. The MID includes a core, and at least one first winding including at least one conductive strip deposited on the core and including at least two turns which are substantially simultaneously shaped. Related apparatus and methods are also disclosed.

  • Programmable electromagnetic array for molecule transport

    An embodiment of the invention relates to a device comprising (1) an array of electromagnetic elements comprising coils, metal cores, and metal core heads, and (2) a controller that is adapted to control a current for one or more coils individually, to vary the current for said one or more coils individually, to reverse the current for one or more coils individually, and to generate a specific magnetic flux distribution and gradient across two or more coils; wherein the metal core head is at one end of the coil and the metal core head has a geometry to create a desired magnetic flux, intensity and gradient, in a region of interest between two adjacent coils; further wherein the device is functionally coupled to a fluidic device to concentrate and transport magnetic particles in a fluid without fluidic movement of the fluid.

  • Fluorometric analysis kit

    Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3'-position, their bioconjugates and their uses are described. 1,3'-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1'-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.

  • Plasmon fluorescence augmentation for chemical and biological testing apparatus

    The sensitivity and durability of fluorescent assays may be increased through structures and methods using plasmon fluorescence augmentation and sealing of the structure against degradation by reagents used in the assay. The resulting structures make practical extremely sensitive fluorescent assays for DNA and other biological analytes.

  • MRI systems having MRI compatible universal delivery cannulas with cooperating MRI antenna probes and related systems and methods

    In vivio deep brain medical probe systems include: (a) an NMRI compatible cannula comprising a plurality of concentric axially extending tubes with a receiving bore; and (b) an elongate antenna member with a conductor and an insulating layer configured to slidably advance through cannula bore to define an MRI receive antenna.

  • BIOMATERIALS WITH ENHANCED PROPERTIES AND DEVICES MADE THEREFROM

    Biomaterials with enhanced properties such as improved strength, flexibility, durability and reduced thickness are useful in the fabrication of biomedical devices, particularly those subjected to continuous or non-continuous loads where repeated flexibility and long-term durability are required. These enhanced properties can be attributed to elevated levels of elastin, altered collagen types, and other biochemical changes which contribute to these enhanced properties. Examples of devices which would be improved by use of such tissue include heart valves, including percutaneous heart valves, and vascular grafts, patches and the like. Such enhanced materials can be sourced from specific populations of animals, such as neonatal calves, or in range-fed adult cattle, or can be fabricated or created from cell populations exhibiting such properties. In one embodiment, glutaraldehyde-fixed neonatal pericardial tissue is used to create leaflets in a percutaneous heart valve, and may be used without chemical fixation, with or without processes to remove residual cellular membranes, and utilized as a scaffold material for tissue engineering.

  • Dual Constrained Methodology for IMT Measurement

    A computer-implemented system and method for intima-media thickness (IMT) measurements using a validation embedded segmentation method. Various embodiments include receiving biomedical imaging data and patient demographic data corresponding to a current scan of a patient; checking the biomedicalimaging data in real-time to determine if an artery of the patient has a atherosclerosis deposit in a proximal wall of the artery; acquiring arterial data of the patient as a combination of longitudinal B-mode or M-mode and transverse B-mode or M-mode data; using a data processor to automatically recognize the artery by embedding anatomic information; using the data processor to calibrate a region of interest around the automatically recognized artery; automatically computing the lumen intima and media-adventita borders by evolving the initial lumen intima and initial media-adventita borders constrained by distances based on polyline method or centerline method; and determining the intima-media thickness (IMT) of an arterial wall of the automatically recognized artery.

  • Diaza Heterocyclic Compounds for Phototherapy

    The invention relates generally to optical agents, including phototherapeutic agents, for biomedical applications, including phototherapy. The invention includes optical agents, and related therapeutic methods, comprising alicyclic diaza compounds, including 1,2 diaza heterocyclic compounds, having a photolabile N--N bond directly or indirectly linked to at least one carbocyclic aromatic and/or heterocyclic aromatic group. In some embodiments, for example, the invention provides alicyclic diaza compounds for phototherapeutic methods having a photolabile N--N bond that undergoes photoactivated cleavage to produce reactive species, such as radicals, ions, etc., that achieve a desired therapeutic effect, such as selective and/or localized tissue damage and/or cell death.

  • TEST KIT AND METHOD FOR MEASUREMENT OF METALS IN BIOLOGICAL FLUIDS

    A test kit and a biomedical process is provided to estimate metals particularly non-transferrin bound iron levels (NTBI) in circulating body fluids particularly, serum. NTBI appears in serum when there is excess iron in the body. The method comprises of employing a signal generating moiety capable of complexing with iron that is a peptide like molecule having an iron binding site and also an optical signal generating functional group. The molecule is of microbial origin. The measurement is based on the alteration of optical characteristics of the probe molecule upon attachment of iron to its binding site on the molecule. Hence it generates a signal proportionate to the amount of iron available for binding and provides a direct estimate of free or unbound iron in the sample. According to this instant invention a rapid estimation method of NTBI in body fluids can be undertaken in an inexpensive way without the need of specialized expertise.

  • METHOD FOR PREPARATION OF BIOACTIVE GLASS COATINGS BY LIQUID PRECURSOR THERMAL SPRAY

    The present invention belongs to the field of biomedical material, and is particularly related to a method of preparing bioactive glass coatings by liquid precursor thermal spray. The objective of the present invention is to overcome the shortcomings of the air plasma spraying where the powder feedstock preparation is complicated and time-consuming, and sol-gel or other wet chemistry method where the synthesized coating generally has thin coating thickness and with low production efficiency. Therefore, a new method is provided for preparation of bioactive glass coatings. In this method, organic and inorganic raw materials were first weighed in accordance with the chemical composition of bioactive glasses, and sol or suspension was prepared; then the sol or suspension was used as the feedstock for thermal spray, and was deposited on the biomedical materials substrate, at high temperature to form the bioactive glass coating. The invention possesses the following advantages: simple operation, less complicated procedures, synthesis with high efficiency, low production cost, suitable for industrial production, and so on. This method can be used to prepare bioactive glass coatings.

  • Alimentary Protein-Based Scaffolds (APS) for Wound Healing, Regenerative Medicine and Drug Discovery

    The invention provides engineered biomaterials derived from plant products. The engineered biomaterials are useful for biomedical applications. The engineered biomaterials are able to support the growth of animal cells.

  • SYSTEMS AND METHODS FOR TEMPORAL MULTIPLEXING X-RAY IMAGING

    The present subject matter relates to systems and methods for temporal multiplexing x-ray imaging of dynamic objects with high temporal resolution and fast imaging speed. A pulsed x-ray beam can irradiate an object undergoing a range of motion such as a cyclic motion. Multiple x-ray images can be acquired at different phases within a single motion cycle or range of the object. The multiple x-ray images can be demultiplexed to produce an individual phase image. Compared to sequential imaging, temporal multiplexing x-ray imaging can achieve high temporal resolution of dynamics object in multiple phases with imaging time comparable to that of a single phase. Temporal multiplexing x-ray imaging can thus be applied to a wide variety of applications, including biomedical imaging and industrial non-destructive testing.

  • COLLIMATION APPARATUS FOR HIGH RESOLUTION IMAGING

    The invention relates to a collimation apparatus for use in biomedical imaging systems. Specifically, the invention relates to a collimation apparatus that blocks a portion of its crystal with a radiation blocking element.

  • Compounds Containing Acyclic N-N Bonds for Phototherapy

    The invention relates generally to optical agents for biomedical applications, including phototherapy. The invention includes optical agents, and related therapeutic methods, comprising compounds with an acyclic N--N bond having at least one aromatic and/or heterocyclic aromatic group providing phototherapeutic agents, including Type 1 phototherapeutic agents. In some embodiments, for example, the invention provides compounds for phototherapeutic methods having one or more photolabile acyclic N--N bonds capable of undergoing photoactivated cleavage to produce reactive species, such as radicals, ions, etc., that achieve a desired therapeutic effect, such as selective and/or localized tissue damage and/or cell death.

  • METHOD FOR PREPARING POROUS HYDROXYAPATITE COATINGS BY SUSPENSION PLASMA SPRAYING

    The present invention relates to a preparation method for porous hydroxyapatite coatings. In particular, it is a method of using suspension plasma spraying to prepare porous hydroxyapatite coatings, which belongs to the technical field of biomedical material preparations. The present invention added a pore-forming agent into the hydroxyapatite suspension with a solid content of 16%-45%. After full stirring, the feedstock materials for plasma spraying were transferred into the injection system, and injected into the high temperature area of the central plasma flame. Then, the feedstock materials made the heat exchange with the high plasma flame of plasma spraying gun. Then the sprayed raw materials were subjected to breakup and refinement of the droplets, solvent evaporation, the decomposition and gasification of the pore-forming agent and melting of feedstock materials. Finally, the porous hydroxyapatite coatings are directly deposited onto the substrate surfaces of thebiomedical materials.

  • Methods for Improved Forewarning of Condition Changes in Monitoring Physical Processes

    This invention teaches further improvements in methods for forewarning of critical events via phase-space dissimilarity analysis of data from biomedical equipment, mechanical devices, and other physical processes. One improvement involves objective determination of a forewarning threshold (U.sub.FW), together with a failure-onset threshold (U.sub.FAIL) corresponding to a normalized value of a composite measure (C) of dissimilarity; and providing a visual or audible indication to a human observer of failure forewarning and/or failure onset. Another improvement relates to symbolization of the data according the binary numbers representing the slope between adjacent data points. Another improvement relates to adding measures of dissimilarity based on state-to-state dynamical changes of the system. And still another improvement relates to using a Shannon entropy as the measure of condition change in lieu of a connected or unconnected phase space.

  • DRY ELECTRODE FOR BIOMEDICAL SIGNAL MEASURING SENSOR

    A dry electrode for biomedical signal measuring sensor includes a conductive sponge, a conductive fabric, and a thin metal film. The conductive fabric covers the whole conductive sponge, and the thin metal film is disposed on one face of the conductive fabric opposite to the conductive sponge. When using the dry electrode in measuring biomedical signal, it is not necessary to apply a conductive gel on a patient's skin, at where the biomedical signal is to be measured. Without the need of applying the conductive gel, the dry electrode is readily for measuring biomedical signal at any time and can be conveniently used in measuring signal over a long period of time without the problem of an attenuated signal due to gradually becoming dried conductive gel.

  • DENDRIMER-LIKE MODULAR DELIVERY VECTOR

    Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. The nucleic acids are used to form dendrimers that are useful as supports, vectors, carriers or delivery vehicles for a variety of compounds inbiomedical and biotechnological applications. In particular, the macromolecules may be used for the delivery of drugs, genetic material, imaging components or other functional molecule to which they can be conjugated. An additional feature of the macromolecules is their ability to be targeted for certain organs, tumors, or types of tissues. Methods of utilizing such biomaterials include delivery of functional molecules to cells.

  • DENDRIMER-LIKE MODULAR DELIVERY VECTOR

    Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. The nucleic acids are used to form dendrimers that are useful as supports, vectors, carriers or delivery vehicles for a variety of compounds inbiomedical and biotechnological applications. In particular, the macromolecules may be used for the delivery of drugs, genetic material, imaging components or other functional molecule to which they can be conjugated. An additional feature of the macromolecules is their ability to be targeted for certain organs, tumors, or types of tissues. Methods of utilizing such biomaterials include delivery of functional molecules to cells.

  • HIGH-FREQUENCY ELECTROPORATION FOR CANCER THERAPY

    The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.

  • INJECTABLE SMART GEL AND METHOD FOR FABRICATING THE SAME

    An injectable smart gel and a method for fabricating the same are disclosed. A basic structural stabilizer/polymeric electrolyte and a diluting solution are added to a modified chitosan to regulate the chitosan solution to have a pH value closing to that of the human body and form a flowable chitosan sol. The flowable chitosan sols formed thereby are respectively converted into inflowable chitosan gels via increasing the temperature thereof to the human body temperature, and via adding calcium ion or regulating the chitosan sol into an acidic solution. The injectable smart gel fabricated thereby is injectable and able to function as a carrier of magnetism-sensitive medicine-containing nanocapsules. The medicine can be released to the injectable smart gel with an external non-contact force, such as a magnetic field, an electric field or an ultrasonic wave, for long-acting and multi-stage medicine delivery. The present invention is very useful in biomedical engineering.

  • NUCLEIC ACID-MEDIATED SHAPE CONTROL OF NANOPARTICLES FOR BIOMEDICAL APPLICATIONS

    Embodiments of a method for nucleic acid-mediated control of a nanoparticle shape are disclosed. In some embodiments, one or more nucleic acid oligomers are adsorbed to a metal nanoseed, and additional metal is deposited onto the nanoseed to produce a shaped nanoparticle. In certain embodiments, the nanoseed is gold and the oligomers are 5-100 nucleotides in length. The nanoparticle shape is determined at least in part by the nucleic acid sequence of the oligomer(s). Shaped nanoparticles produced by embodiments of the method include nanoflowers, nanospheres, nanostars, and nanoplates. Embodiments for using the shaped nanoparticles also are disclosed.

  • STEREO DATA REPRESENTATION OF BIOMEDICAL SIGNALS ALONG A LEAD

    Various embodiments concern sensing bioelectrical signals using electrodes along a lead, the electrodes having a spatial configuration along the lead, generating signal data sets, one signal data set being generated for each bioelectrical signal, and graphically representing the electrodes and data representations of the signal data sets on a display. In various embodiments, each data representation indicates a parameter of a respective one of the data sets, the electrodes are graphically represented on the display in a spatial configuration representative of the spatial configuration of the electrodes along the lead, and each data representation is graphically represented on the display in spatial association with at least one electrode through which the bioelectrical signal on which the signal data set is based was sensed. The parameter can be indicative of the relative presence of a biomarker in the bioelectrical signals.

  • IN SITU FORMING HYDROGEL AND BIOMEDICAL USE THEREOF

    Disclosed are in situ-forming injectable hydrogel and medical uses thereof. In the in situ-forming injectable hydrogel two or more homogeneous or heterogeneous polymers are bonded to each other by a dehydrogenation reaction between phenol or aniline moieties on adjacent polymers, wherein a polymer backbone is grafted with a phenol or aniline moiety using a linker. In contrast to conventional hydrogel, the in situ-forming injectable hydrogel is superior in terms of in vivo stability and mechanical strength thanks to the introduction of a water-soluble polymer as a linker which leads to an improvement in the reactivity of phenol or aniline moieties. Having the advantage of superior bio stability and mechanical strength, the hydrogel finds a variety of applications in the biomedical field.

  • Anti-Adhesive Barrier Membrane Using Alginate and Hyaluronic Acid for Biomedical Applications

    A non-synthetic, hydrophilic, biodegradable, biocompatible polysaccharide based non-toxic anti-adhesion hydrogel barrier is disclosed herein. The barrier of the present invention is formed by constructing a unique interpenetrating, crosslinked network with a unique porosity. Furthermore, the barrier of the present invention is comprised of tunable biopolymers for controllable mechanical robustness and degradation. The barrier of the present invention effectively reduces unwanted adhesions using non-synthetic components.

  • MULTIFUNCTIONAL STEALTH NANOPARTICULES FOR BIOMEDICAL USE

    The present invention relates to the field of drug delivery nanosystems. More precisely, the present invention concerns a copolymer with advantageous properties for the outer coating of various nanoparticles. Said copolymer comprises at least three types of monomers with stealthy, coupling and therapeutic properties respectively, as well as an optional fourth type of monomers with targeting properties. The present invention also relates to core-shell or hollow shell nanoparticles coated by an external layer of the copolymer according to the invention. Several types of core-shell nanoparticles are envisaged. The invention also concerns methods for preparing said nanoparticles, as well as pharmaceutical compositions or medicaments comprising them.

  • BIOMEDICAL DEVICES CONTAINING INTERNAL WETTING AGENTS

    This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.

  • ELECTROSPUN SILK MATERIAL SYSTEMS FOR WOUND HEALING

    The present invention relates to the processes of preparing silkfibroin/polyethylene oxide blended materials, and the resulting materials thereof, which are suitable for biomedical applications such as wound healing. In particular, the electrospun silk fibroin/PEO mats with a silk:PEO blend ratio of 2:1 to 4:1, treated with controlled evaporation, constraint-drying techniques, and/or alcohol treatment, and/or PEO extraction, demonstrate suitable physical and biofunctional properties, such as fiber structure, topography, absorption, water vapor transmission rates, oxygen permeation, and biodegradability, relevant to biomaterial systems with utility for wound dressings.

  • NI AND CU FREE PD-BASED METALLIC GLASSES

    The invention is directed to Pd-based metallic glass alloys useful in biomedical applications having no Ni or Cu. Exemplary metallic glass alloys are represented by A.sub.aB.sub.b{(Si).sub.100-c(D).sub.c}.sub.d, where A may be selected from Pd, and combinations of Pd and Pt, B may be selected from Ag, Au, Co, Fe, and combinations thereof, and D may be selected from P, Ge, B, S. Also, a, b, c and d are atomic percentages, and a ranges from about 60 to about 90, b ranges from about 2 to about 18, d ranges from about 5 to about 25, and c is greater than 0 and less than 100.

  • IN SITU-FORMING HYDROGEL FOR TISSUE ADHESIVES AND BIOMEDICAL USE THEREOF

    Disclosed herein are an in situ-forming, bioadhesive hydrogel and the medical uses thereof. Being formed by in situ crosslinking through an enzymatic reaction, the hydrogel has an advantage over conventional bioadhesive hydrogels in terms of biocompatibility. In addition, the in situ-forming bioadhesive hydrogel has excellent biocompatibility and mechanical strength and has excellent tissue adhesiveness thanks to modification with/without dopa derivatives. The hydrogel finds a variety of applications in the biomedical field, including bioadhesives or hemostats, implant substances for tissue regeneration and augmentation, carriers for delivering biologically active materials or drugs, etc.

  • THREE-DIMENSIONAL BIOPRINTING OF BIOSYNTHETIC CELLULOSE (BC) IMPLANTS AND SCAFFOLDS FOR TISSUE ENGINEERING

    A novel BC fermentation technique for controlling 3D shape, thickness and architecture of the entangled cellulose nano-fibril network is presented. The resultant nano-cellulose based structures are useful as biomedicalimplants and devices, are useful for tissue engineering and regenerative medicine, and for health care products. More particularly, embodiments of the present invention relate to systems and methods for the production and control of 3-D architecture and morphology of nano-cellulose biomaterials produced by bacteria using any biofabrication process, including the novel 3-D Bioprinting processes disclosed. Representative processes according to the invention involve control of the rate of production of biomaterial by bacteria achieved by meticulous control of the addition of fermentation media using a microfluidic system. In exemplary embodiments, the bacteria gradually grew up along the printed alginate structure that had been placed into the culture, incorporating it. After culture, the printed alginate structure was successfully removed revealing porosity where the alginate had been placed. Porosity and interconnectivity of pores in the resultant 3-D architecture can be achieved by porogen introduction using, e.g., ink-jet printer technology.

  • THREE-DIMENSIONAL BIOPRINTING OF BIOSYNTHETIC CELLULOSE (BC) IMPLANTS AND SCAFFOLDS FOR TISSUE ENGINEERING

    A novel BC fermentation technique for controlling 3D shape, thickness and architecture of the entangled cellulose nano-fibril network is presented. The resultant nano-cellulose based structures are useful as biomedicalimplants and devices, are useful for tissue engineering and regenerative medicine, and for health care products. More particularly, embodiments of the present invention relate to systems and methods for the production and control of 3-D architecture and morphology of nano-cellulose biomaterials produced by bacteria using any biofabrication process, including the novel 3-D Bioprinting processes disclosed. Representative processes according to the invention involve control of the rate of production of biomaterial by bacteria achieved by meticulous control of the addition of fermentation media using a microfluidic system. In exemplary embodiments, the bacteria gradually grew up along the printed alginate structure that had been placed into the culture, incorporating it. After culture, the printed alginate structure was successfully removed revealing porosity where the alginate had been placed. Porosity and interconnectivity of pores in the resultant 3-D architecture can be achieved by porogen introduction using, e.g., ink-jet printer technology.

  • SILK NANOSPHERES AND MICROSPHERES AND METHODS OF MAKING SAME

    The present invention provides for methods of preparing silk nanoparticles and microparticles, methods of encapsulating an active agent into the silk nano- and microparticles and compositions comprising these silk particles. In particular, the silk spheres are prepared from phase separation of silk and polyvinyl alcohol (PVA), without exposure to an organic solvent. The method employs a chemical, PVA, which is an FDA-approved ingredient in drug formulations. Different parameters can be adjusted to control the size and shape of the silk spheres during the fabrication process. The silk particle compositions of the present invention may also encapsulate active agents or chemicals. Such compositions allow the active agents to be controllably and sustainably released to the target organs or tissues. The silk composition entrapping active agents also provides for a long-term storage medium for the active agents so entrapped. The silk nano- and microparticles of the present invention are thus suitable for a variety of biomedical and pharmaceutical applications, such as drug delivery or tissue engineering.

  • PROBABILISTIC BIOMEDICAL PARAMETER ESTIMATION APPARATUS AND METHOD OF OPERATION THEREFOR

    A probabilistic digital signal processor for medical function is described. Initial probability distribution functions are input to a dynamic state-space model, which operates on state and/or model probability distribution functions to generate a prior probability distribution function, which is input to a probabilistic updater. The probabilistic updater integrates sensor data with the prior to generate a posterior probability distribution function passed to a probabilistic sampler, which estimates one or more parameters using the posterior, which is output or re-sampled in an iterative algorithm. For example, the probabilistic processor operates using a physical model on data from a medical meter, where the medical meter uses a first physical parameter, such as blood oxygen saturation levels from a pulse oximeter, to generate a second physical parameter not output by the medical meter, such as a heart stroke volume, a cardiac output flow rate, and/or a blood pressure.

  • META-DATA APPROACH TO QUERYING MULTIPLE BIOMEDICAL ONTOLOGIES

    A method for retrieving information spread across a plurality of different ontologies, including: defining a meta-ontology, wherein the meta-ontology includes high-level properties and their mappings to specific properties defined in a plurality of different ontologies; receiving a question, wherein the question is associated with a high-level property; and providing an answer to the question, wherein the answer is determined by using the meta-ontology

  • BIOMEDICAL ELECTRODE

    An electrode and electrodes for a biomedical system is provided. The electrode includes a backing pad with top and bottom surfaces. A conductive element is attached to the bottom surface of the backing pad, and a conductive gel layer covers at least part of the bottom surface of the conductive element. A bonding layer is disposed at least in part between the conductive element and the conductive gel layer. The electrode can include a leadwire with a stripped end length, and at least a portion of the stripped end length is disposed between the conductive element and at least one of the bonding layer and the conductive gel layer.

  • SURFACE COATING FOR BIOMOLECULE IMMOBILISATION AND MINIMISATION OF NON-SPECIFIC BINDING ON SURFACES FOR BIOMEDICAL DIAGNOSTICS

    A solid substrate coating capable of swelling by a factor of at least 2 on contact with an aqueous solution. The solid substrate coating may be prepared by activating the surface of a solid substrate by treatment with a plasma, depositing a first layer of siloxane onto the surface of the solid substrate using plasma, and depositing a second layer of at least on chemical functionality on top of the first layer using plasma.

  • LIGHTING DESIGN OF HIGH QUALITY BIOMEDICAL DEVICES

    The invention relates to a plurality of light sources to power a variety of applications including microarray readers, microplate scanners, microfluidic analyzers, sensors, sequencers, Q-PCR and a host of other bioanalytical tools that drive today's commercial, academic and clinical biotech labs.

  • Process for coupling a polymeric component to a metal component forming part of or a biomedical joint prosthesis

    A process for coupling a polymer component to a metal component forming part of a biomedical joint prosthesis includes the steps of providing the polymer component, providing the metal component having a surface with the same geometry/curvature of the surface of the polymer component to be coated, putting in contact the polymer component with the metal component, and heating only the metal component to a process temperature equal to or higher than the melting temperature of the polymer component to achieve a local softening or melting of the polymer component at the contact surface between the two components.

  • System and Method for Medical Diagnosis Using Geospatial Location Data Integrated with Biomedical Sensor Information

    In at least one embodiment, a method and system for accumulating geospatial location data and biomedical data for an individual during his/her travels is provided. In at least one embodiment, a device uses at least one location signal to determine geospatial data and receives a plurality of biomedical signals with both data types being stored for possible later retrieval for providing a diagnosis for the individual if a medical condition arises. An embodiment of the invention provides a method of operation of a device having at least a memory and a communications module where the method includes receiving at least one location signal with the communications module; storing geospatial data obtained at least from the at least one location signal with a time stamp in memory; receiving a plurality of biomedical signals over time from at least one sensor with the communications module; storing biomedical data from the received biomedical signal with a time stamp in memory; and repeating the receiving at least one location signal and storing geospatial data from the at least one location signal in different geographic locations.

  • ARTIFICIAL DURA BIOMEDICAL DEVICE AND BRAIN SURGERY METHOD UTILIZING THE SAME

    An artificial dura biomedical device and a brain surgery method utilizing the same are disclosed. The steps includes: fixing an artificial dura to a partial skull; and fixing the partial skull with the artificial dura to a cut hole of a whole skull. The artificial dura biomedical device includes an artificial dura and a connecting element. The connecting element fixes the partial skull with the artificial dura.

  • SINGLE-USE BIOMEDICAL SENSORS

    A disposable self-powered biomedical sensor comprises a printed wet electrode on a substrate sheet. The wet electrode is provided with an electrolyte element to enhance the electrical contact with a surface to be measured. Moreover, a printed battery encapsulated in a hermetically sealed compartment is provided on the substrate sheet. The disposable self-powered sensor can be stored within an enclosure or a package which provides a proper atmosphere to prevent the drying of the electrolyte and prolong the shelf life of the sensors.

  • COMPOSITE MATERIAL WITH PROPERTIES OF SELF-HEALING AND RELEASE OF ACTIVE INGREDIENTS, FOR BIOMEDICAL APPLICATIONS

    This invention relates to a composite material for biomedical applications, in particular dental applications, which possesses self-healing capacity and is able to incorporate a system for the release of active ingredients at the stage of application and use.

  • FABRICATING MICROFLUIDIC STRUCTURES FOR BIOMEDICAL APPLICATIONS

    Microfluidic structures featuring substantially circular channels may be fabricated by embossing polymer sheets.

  • GLYCOSYLTRANSFERASE REVERSIBILITY FOR SUGAR NUCLEOTIDE SYNTHESIS AND MICROSCALE SCANNING

    The present invention generally relates to materials and methods for exploiting glycosyltransferase reversibility for nucleotide diphosphate (NDP) sugar synthesis. The present invention provides engineered glycosyltransferase enzymes characterized by improved reaction reversibility and expanded sugar donor specificity as compared to corresponding non-mutated glycosyltransferase enzymes. Such reagents provide advantageous routes to NDP sugars for subsequent use in a variety of biomedical applications, including enzymatic and chemo-enzymatic glycorandomization.

  • SYNTHESIS AND CHARACTERIZATION OF NEAR IR FLUORESCENT MAGNETIC AND NON-MAGNETIC ALBUMIN NANOPARTICLES FOR BIOMEDICALAPPLICATIONS

    The present invention discloses Near Infrared (NIR) fluorescent albumin nanoparticles having a structure selected from a core structure or a core-shell structure. Also disclosed are a process of preparing these NIR fluorescent albumin nanoparticles, and a method of in vivo detection of pathologies, in particular cancer pathology, by using administering these NIR fluorescent albumin nanoparticles to a patient.

  • IMPLANTABLE BIOMEDICAL DEVICE LEADS COMPRISING LIQUID CONDUCTORS

    Implantable biomedical device leads comprising liquid conductors. In an exemplary embodiment of a lead for use in a biomedical application of the present disclosure, the lead comprises a lead body having a distal end and a proximal end, the lead body defining a first interior lumen therethrough, and an electrically conductive composition positioned within the first interior lumen, the electrically conductive composition comprising a metal in a liquid state at or below about 98.degree. F. In another embodiment, the electrically conductive composition is selected from the group consisting of gallium, a gallium-indium alloy, Galinstan, its/their alloys, and combinations thereof. In various embodiments, the metallic electrically conductive composition is used along with a second non-metallic electrically conductive composition such as a conductive polymer, an electrically conductive liquid, an electrically conductive gel, or combinations thereof.

  • Micro-Devices for Biomedical Applications and Method of Use of Same

    Among others, the present invention provides fabricated micro-devices for application in live biological systems, each comprising (a) an outer membrane, (b) a micro-mechanical, micro-chemical, micro-chemical-mechanical, micro-optical, micro-acoustical, micro-biological, micro-bio-chemical, micro-bio-chemical-mechanical, micro-electro-bio-chemical-mechanical, micro-electro-chemical-mechanical, micro-electro-bio-chemical-mechanical, micro-electro-mechanical, micro-electromagnetic-mechanical, micro-acoustic-mechanical, and micro-superconducting-mechanical properties, and (c) having a size as defined by the outer membrane ranging from 1 angstrom to 5 millimeters; and methods of using such fabricated micro-devices.

  • BIOMEDICAL MATERIALS FOR TISSUE ENGINEERING

    In an embodiment of the disclosure, a biomedical material is provided. The biomedical material includes a biocompatible material having a surface and a carrier distributed over the surface of the biocompatible material, wherein both of the biocompatible material and the carrier have no charges, one of them has charges or both of them have charges with different electricity. The biomedical material is utilized for dentistry, orthopedics, wound healing or medical beauty and applied in the repair and regeneration of various soft and hard tissues.

  • DEXTRIN HYDROGEL FOR BIOMEDICAL APPLICATIONS

    A hydrogel formulation of oxidized dextrin is reticulated with adipic acid dihydrazide, which may embody polysaccharides, proteins, nanogels, granular materials, bioactive molecules and cells for tissue regeneration and controlled drug delivery. A hydrogel can be injectable, highly biocompatible and biodegradable, for tissue regenerative applications, performing simultaneously as a vehicle e.g. for nanogels, granular materials and cells, and as controlled drug delivery systems, e.g. of hydrophobic molecules and therapeutic proteins.

  • FABRICATION METHOD OF A NOVEL ARTIFICIAL CORTICAL BONE USING A MULTI-PASS EXTRUSION PROCESS

    A method for fabricating an artificial bone by multi-pass extrusion, includes: a first extrusion process of forming roll-shaped filaments having sheets of calcium phosphate/calcium phosphate-(t-ZrO.sub.2)/t-ZrO.sub.2; a second extrusion process of arranging the prepared roll-shaped filaments circularly and extruding the same; and a third extrusion process of forming an external shell of hydroxyapatite (HAp). The method for fabricating an artificial bone allows fabrication of an artificial bone having the biocompatibility and mechanical strength of the natural bone and may be utilized variously in biomedical engineering, medicine and other applications.

  • BIOABSORBABLE POLYMERS FROM BIOABSORBABLE POLYISOCYANATES AND USES THEREOF

    Novel bioabsorbable and/or biocompatible polyurethanes, polyureas, polyamideurethanes and polyureaurethanes with tunable physical, mechanical properties and hydrolytic degradation profiles are provided for use inbiomedical applications such as stents, stent coatings, scaffolds, foams, and films. The disclosed polymers may be derived from biocompatible and/or bioabsorbable polyisocyanates. The present invention also relates to new and improved methods for the preparation of the biocompatible and/or bioabsorbable polyisocyanates.

  • BIOMEDICAL MATERIALS FOR TISSUE ENGINEERING

    In an embodiment of the disclosure, a biomedical material is provided. The biomedical material includes a biocompatible material having a surface and a carrier distributed over the surface of the biocompatible material, wherein both of the biocompatible material and the carrier have no charges, one of them has charges or both of them have charges with different electricity. The biomedical material is utilized for dentistry, orthopedics, wound healing or medical beauty and applied in the repair and regeneration of various soft and hard tissues.

  • Flexible and Stretchable Electronic Systems for Epidermal Electronics

    Provided herein are skin-mounted biomedical devices and methods of making and using biomedical devices for sensing and actuation applications. For example, flexible and/or stretchable biomedical devices are provided, including electronic devices useful for establishing conformal contact with the skin of a subject. Devices disclosed herein can comprise a plurality of sensing and/or actuating devices provided as part of a skin-mounted flexible or stretchable electronic circuit.

  • Silk-Based Ionomeric Compositions

    Disclosed herein are pH-dependent silk fibroin-based ionomeric compositions and colloids, and methods of making the same. The state of the silk fibroin ionomeric compositions is reversible and can transform from a gel-like colloid to a more fluid-like solution, or vice versa, upon an environmental stimulus, e.g., pH. Thus, the silk-based ionomeric compositions and colloids can be applied in various industries, ranging from electronic applications to biomedical applications, such as sensors, gel diodes, absorbent materials, drug delivery systems, tissue implants and contrast agents.

  • REMOVING ENVIRONMENT FACTORS FROM SIGNALS GENERATED FROM VIDEO IMAGES CAPTURED FOR BIOMEDICAL MEASUREMENTS

    What is disclosed is a system and method for automatically removing undesirable periodic or random background noise from heart rate measurement signals obtained from a video camera, ambient illuminator and other unknown electromagnetic sources to improve the overall reliability of biomedical measurements. In one embodiment, a time varying video image acquired over at least one imaging channel of a subject of interest is received. The video images are then segmented into a first region comprising a localized area where plethysmographic signals of the subject can be registered and a second region comprising a localized area of the environment where the plethysmographic signals cannot be registered. Both of the regions are exposed to the same environmental factors. The segmented video signals are pre-processed and the processed signals are subtracted from each other to generate an environmentally compensated signal. The environmentally compensated signal is then communicated to a computer system.

  • BIOMEDICAL PATCHES WITH ALIGNED FIBERS

    A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes.

  • FUNCTIONALIZATION OF GOLD NANOPARTICLES WITH ORIENTED PROTEINS, APPLICATION TO THE HIGH-DENSITY LABELING OF CELL MEMBRANES

    The present invention relates to nanoparticles the surface of which is modified by deposition of proteins. The invention further relates to a method for producing said nanoparticles and to their use in biological research and in the biomedical field (for example labelling and diagnosis).

  • NANOPARTICLE COMPOSITION AND METHODS TO MAKE AND USE THE SAME

    The present invention provides a novel nanoparticle drug delivery system generated from poly(ortho ester) polymers with sustained drug release capability and can be functionalized to allow for systemic delivery to various organ systems throughout the body. One important aspect of this invention is that the nanoparticle drug delivery system generated from poly(ortho ester) polymers encapsulate several types of drugs in poly(ortho ester) nanoparticles, including but not limited to lipophilic, hydrophilic small and large molecules and also hydrophilic and lipophilic dyes by adopting appropriate emulsion techniques. These poly(ortho ester) nanoparticles are biodegradable, biocompatible and controlled release drug delivery system with zero order kinetics, which can be used in various biomedical applications such as eye-related diseases, cancer, arthritis, etc.

  • BIOCOMPATIBLE POLY (AMIC ACID) AND METHOD OF PREPARATION THEREOF

    A method is provided for the preparation of a poly(amic acid) in which ring opening polymerization is employed to react the monomers ethylenediaminetetraacetic dianhydride and paraphenylenediamine in an aprotic solvent. The resulting poly(amic acid) composition is suitable as a biocompatible material, such as a biomedical implant, implant coating material, tissue scaffold material, controlled release drug delivery vehicle, and cellular growth substrate.

  • DEVICE FOR TRANSFERRING AND DOSING BIOMEDICAL FLUIDS BETWEEN HOSPITAL CONTAINERS

    A device for transferring and dosing biomedical fluids between hospital containers includes a syringe body for containment of a biomedical fluid and a piston sealed fitted in a sliding way therein, the syringe body including a first extremity having joining elements to a first container and to a second container, and a second extremity opposite the first extremity, the device including: a handle for manually gripping and having a coupling seat for fastening to the second extremity; motorised element mounted in the handle for operating a thrust rod for pushing the piston; first temporary fastening elements placed between the coupling seat and second extremity; second temporary fastening elements placed between the piston and thrust rod; and control elements mounted on the handle, associated with the motorised element for dosing volumetric quantities of biomedical fluid from the first container and dispensing to the second container.

  • COMPOSITE MATERIAL SUITABLE FOR BIOMEDICAL USE, AND METHOD TO PRODUCE IT

    Composite material suitable for biomedical use, comprising a first phase consisting of a reticulated hydrogel deriving from a polymer chosen from among polymers N-methyl-amides derivatives of carboxymethylcellulose, alginic acid or carboxymethyl starch and a second phase which comprises a solution of the above polymers.

  • BIOMEDICAL IMPLANTS COMPRISING SURFACE-MODIFIED CERAMIC PARTICLES AND BIODEGRADABLE STEREO COMPLEX POLYMERS, ITS USE FOR SUPPRESSING INFLAMMATION AND IMPROVEMENT OF MECHANICAL PROPERTY, AND PREPARATION METHOD THEREOF

    A biomedical implant according to this invention comprises ceramic complex, which includes a surface-modified basic ceramic particles, which are basic ceramic particles modified their surface with first biodegradable polymers, and the second biodegradable polymers. The first and second biodegradable polymer are combined each other and form a stereo complex. The biomedical implant has a superior effect to suppress inflammation caused by degradation of biodegradable polymers with improving its mechanical property.

  • DISPOSABLE LOW-PROFILE CONFORMABLE BIOMEDICAL SENSOR

    A disposable, low profile biomedical sensor for detecting electrical signals from muscles and which consists of a framework of malleable and flexible component layers supporting an arrangement of conductor leads embedded within electrically conductive, adhesive, cross-linked hydrophilic polymer gel components configured to form signal detection and reference electrode contacts. The combination of component layers provides a sensor and lead cable that is flexible and can be contoured to conform to the underlying musculature. The mechanical and electrical configurations act in synergy to shield the sensor and lead cable from external electrical fields and suppress movement artifact.

  • NITRIC OXIDE AND ITS BIOMEDICAL SIGNIFICANCE

    A pharmaceutical composition for stimulating nitric oxide production in mammalian cells, the pharmaceutical composition including at least one compound selected from a group consisting of: 2,3-dihydroxypropyl oleate; bis(m-phenoxyphenyl) ether; 6-acetyl-5,6,6a,7-tetrahydro-4H-dibezo(de,g)quinoline; and (+)-N-(p-(2-methylbutoxy)benzylidene)-4-(2-methylbutyl)aniline.

  • HYDROGEL FILAMENTS FOR BIOMEDICAL USES

    Described herein are apparatus, compositions, systems and associated methods to occlude structures and malformations with radiopaque hydrogel filaments with delayed controlled rates of expansion permitting the repositioning of the device once inside the structure or malformation. Further described is a device for implantation in an animal comprising a difunctional, low molecular weight ethylenically unsaturated shapeable macromer; an ethylenically unsaturated monomer; and a radiopaque element, wherein said device contains no support members. Methods of forming such devices are also disclosed.

  • HYDROGEL FILAMENTS FOR BIOMEDICAL USES

    Described herein are apparatus, compositions, systems and associated methods to occlude structures and malformations with radiopaque hydrogel filaments with delayed controlled rates of expansion permitting the repositioning of the device once inside the structure or malformation. Further described is a device for implantation in an animal comprising a difunctional, low molecular weight ethylenically unsaturated shapeable macromer; an ethylenically unsaturated monomer; and a radiopaque element, wherein said device contains no support members. Methods of forming such devices are also disclosed.

  • MODIFICATION OF BIOMEDICAL POLYMERS FOR PREVENTION OF FOULING AND CLOTTING

    A surface-modified polymer is described, comprising a polymeric material and a self-assembling monolayer covalently bound thereto. The monolayer comprises monoethylene glycolated-OH (MEG-OH); 2-(3-trichlorosilyl-propyloxy)-ethyl-trifluoroacetate (7-OEG or MEG-TFA); 2,2,2-trifluoroethyl-13-trichlorosilyl-tridecanoate (TTTA); OEGylated TTTA (OEG-TTTA); S-(2-(2-(2-(3-trichlorosilyl-propyloxy)-ethoxy)-ethoxy)-ethyl)-benzenethi- osulfonate (OEG-TUBTS); or a combination thereof. Methods are described for forming a surface-modified polymer by surface activation, such as with plasma. By utilizing the surface-modified polymer to make medical equipment or devices for contacting biological fluids, a reduction in surface fouling and thrombus formation can result. Advantageously, polymeric equipment or components so modified may have a reduction in unwanted chemical interactions leading to fouling or clotting. Short trichlorosilane surface modifiers allow films to be deposited onto poly(ethylene terephthalate), polycarbonate, polypropylene, polyvinyl chloride, polyurethane, and other polymers activated using plasma.

  • SYSTEM AND METHOD FOR BIOMEDICAL MEASUREMENT WITH VOICE NOTIFICATION FEATURE

    A system for biomedical measurement with a voice notification feature includes a biomedical measurement device that generates a command based on at least one of a physiological signal obtained by the biomedical measurement device as a result of a measured physiological condition of a user, and an operation phase of the biomedical measurement device, and a mobile device that is coupled to and separate from the biomedical measurement device. The mobile device receives the command from the biomedical measurement device, generates a voice notification signal according to the command and pre-established voice data, and outputs audibly the voice notification signal.

  • BIOMEDICAL IMPLANT WITH A MONOLITHIC TIMING CONTROL BASED RECTIFIER FOR MULTIVOLTAGE FOR BIOMEDICAL APPLICATIONS

    A biomedical implant is provided for simultaneously generating multiple voltages for digital and analog circuits. Two AC voltages induced from an external single AC source located externally to the biomedical implant are used as input to a multi-voltage rectifier. The multi-voltage rectifier has a rectifier circuitry for simultaneously generating: (i) both low positive and negative voltages and (ii) both high positive and negative voltages. A startup circuitry is designed to stabilize both low positive and negative voltages prior to stabilizing both high positive and negative voltages. A timing control circuitry is used to prevent reverse leakage currents from loading capacitors to input for efficiency enhancement. The biomedical implant, by virtue of the multi-voltage timing control rectifier, achieves high power transfer efficiency greater than 85%.

  • BIOMEDICAL HAEMOSTATIC POWDER DISPENSER

    A biomedical haemostatic powder dispenser (1) by which individual doses of powdered medication that are stored in respective chambers of a rotatable carousel (22) are fluidized for delivery to a targeted treatment site (e.g., a wound in order to stop bleeding). In particular, a squeeze handle (7) is activated (i.e., depressed) so as to cause a blast of gas under pressure to be applied from a gas reservoir (30) to a particular one of the powder-filled chambers of the medication carousel so that a single measured does of medication is entrained and delivered to the patient. At the same time that the squeeze handle is activated, the medication carousel is rotated so that a different powder-filled chamber is moved within a fluid path between the gas reservoir and an outlet nozzle tube (10) of the dispenser and a kit for dispensing a powder.

  • NITRIC OXIDE-RELEASING PARTICLES FOR NITRIC OXIDE THERAPEUTICS AND BIOMEDICAL APPLICATIONS

    The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.