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Inventi Rapid - Biomedical Imaging

Patent Watch

  • EXTENDED INTERIOR METHODS AND SYSTEMS FOR SPECTRAL, OPTICAL, AND PHOTOACOUSTIC IMAGING

    The present invention relates to the field of medical imaging. More particularly, embodiments of the invention relate to methods, systems, and devices for imaging, including for tomography-based applications. Embodiments of the invention include, for example, a computed tomography based imaging system comprising: (a) at least one wide-beam gray-scale imaging chain capable of performing a global scan of an object and acquiring projection data relating to the object; (b) at least one narrow-beam true-color imaging chain capable of performing a spectral interior scan of a region of interest (ROI) of and acquiring projection data relating to the object; (c) a processing module operably configured for: (1) receiving the projection data; (2) reconstructing the ROI into an image by analyzing the data with a color interior tomography algorithm, aided by an individualized gray-scale reconstruction of an entire field of view (FOV), including the ROI; and (d) a processor for executing the processing module. The extended interior methods and systems for spectral, optical, and photoacoustic imaging presented in this application can lead to better medical diagnoses by providing images with higher resolution or quality, and can lead to safer procedures by providing systems capable of reducing a patient's exposure time to, and thus quantity of, potentially harmful x-rays. Embodiments of the invention also provide tools for real-time tomography-based analyses.

  • Method And Apparatus For Depth-Resolved Fluorescence, Chromophore, and Oximetry Imaging For Lesion Identification During Surgery

    A tomographic fluorescent imaging device for imaging fluorophores in biological tissues has a scanned laser for scanning the tissue and a camera for receiving light from the biological tissue at an angle to the beam at a second wavelength ten or more nanometers greater in wavelength than the wavelength of the laser. Use of both intrinsic and extrinsic fluorophores is described. Images are obtained at each of several positions of the beam. An image processing system receives the series of images, models a path of the beam through the tissue, and determines depth of fluorophore in tissue from intersections of the modeled path of the beam and the path of the received light. The laser is of 600 nm or longer wavelength, to provide penetration of tissue. The imaging device is used during surgery to visualize lesions of various types to ensure complete removal of malignant tumors. An alternative embodiment uses differences in intensity of fluorescent radiation from tissue as observed at different wavelengths to determine depth of fluorophore in tissue. An embodiment operates at multiple wavelengths to construct tomographic images of chromophores, such as hemoglobin, and is capable of dynamic imaging.

  • Azo Derivatives and Uses Thereof in Phototherapy

    The invention relates generally to optical agents, including Type 1 phototherapeutic agents, for biomedical applications, such as phototherapy. Provided are fused ring azo and diaza compounds comprising a plurality of fused rings including a first ring having an intra-ring azo or intra-ring diaza group capable of activation upon exposure to electromagnetic radiation in visible and/or infrared regions of the electromagnetic spectrum. Optical agents of the invention enable a versatile phototherapy platform for treatment of a range of pathological conditions, including the treatment of cancers, stenosis and inflammation. The invention further provides preparations and formulations comprising the fused ring azo and diaza compounds and methods of making and using the fused ring azo and diaza compounds as optical agents in in vivo or ex vivo biomedical procedures.

  • Method for Shear Wave Ultrasound Vibrometry with Interleaved Push and Detection Pulses

    A shear wave dispersion ultrasound vibrometry ("SDUV") method for measuring a mechanical property of a subject is provided. Particularly, a set of ultrasonic vibration tone bursts is applied to a vibration origin in the subject so that harmonic vibratory motion is imparted to a tissue of interest. The set of vibration tone bursts effectively act like a single vibration pulse that imparts vibratory motion at larger amplitudes than achievable with a single pulse. Multiple ultrasonic detection pulses are then applied to two or more locations in the tissue of interest in order to measure shear waves propagating outward from the vibration origin. From these measurements, phase or amplitude information related to the shear wave propagation is determined and used to calculate a shear wave speed. Using the shear wave speed information, mechanical properties of the tissue are calculated.

  • WATER SOLUBLE NANOCRYSTALLINE QUANTUM DOTS

    An economic, direct synthetic method for producing water soluble QDs that are ready for bioconjugation is provided. The method can produce aqueous QDs with emission wavelengths varying from 400 nm to 700 nm. Highly luminescent metal sulfide (MS) QDs are produced via an aqueous synthesis route. MS QDs are capped with thiol-containing charged molecules in a single step. The resultant MS QDs exhibit the distinctive excitonic photoluminescence desired of QDs and can be fabricated to avoid undesirable broadband emissions at higher wavelengths. This provides a significant improvement over the present complex and expensive commercial processes for the production of QDs. The aqueous QDs are stable in biological fluids over a long period of time. In addition, nontoxic ZnS QDs have been produced with good photoluminescence properties by refluxing the ZnS QD suspensions over a period of time.

  • Thiadiazole Compounds and Uses Thereof

    Thiadiazole compounds, compositions, bioconjugates, and methods for targeting and photoactivation at target sites.

  • IMAGING BASED SYMPTOMATIC CLASSIFICATION AND CARDIOVASCULAR STROKE RISK SCORE ESTIMATION

    Characterization of carotid atherosclerosis and classification of plaque into symptomatic or asymptomatic along with the risk score estimation are key steps necessary for allowing the vascular surgeons to decide if the patient has to definitely undergo risky treatment procedures that are needed to unblock the stenosis. This application describes a statistical (a) Computer Aided Diagnostic (CAD) technique for symptomatic versus asymptomatic plaque automated classification of carotid ultrasound images and (b) presents a cardiovascular stroke risk score computation. We demonstrate this for longitudinal Ultrasound, CT, MR modalities and extendable to 3D carotid Ultrasound. The on-line system consists of Atherosclerotic Wall Region estimation using AtheroEdge.TM. for longitudinal Ultrasound or Athero-CTView.TM. for CT or Athero-MRView from MR. This greyscale Wall Region is then fed to a feature extraction processor which computes: (a) Higher Order Spectra; (b) Discrete Wavelet Transform (DWT); (c) Texture and (d) Wall Variability. The output of the Feature Processor is fed to the Classifier which is trained off-line from the Database of similar Atherosclerotic Wall Region images. The off-line Classifier is trained from the significant features from (a) Higher Order Spectra; (b) Discrete Wavelet Transform (DWT); (c) Texture and (d) Wall Variability, selected using t-test. Symptomatic ground truth information about the training patients is drawn from cross modality imaging such as CT or MR or 3D ultrasound in the form of 0 or 1. Support Vector Machine (SVM) supervised classifier of varying kernel functions is used off-line for training. The Atheromatic.TM. system is also demonstrated for Radial Basis Probabilistic Neural Network (RBPNN), or Nearest Neighbor (KNN) classifier or Decision Trees (DT) Classifier for symptomatic versus asymptomatic plaque automated classification. The obtained training parameters are then used to evaluate the test set. The system also yields the cardiovascular stroke risk score value on the basis of the four set of wall features.

  • ULTRASOUND CAROTID MEDIA WALL CLASSIFICATION AND IMT MEASUREMENT IN CURVED VESSELS USING RECURSIVE REFINEMENT AND VALIDATION

    A computer-implemented system and method for intima-media thickness (IMT) measurements using a validation embedded segmentation method. Various embodiments include receiving biomedical imaging data and patient demographic data corresponding to a current scan of a patient; checking the biomedical imaging data in real-time to determine if an artery of the patient has a calcium deposit in a proximal wall of the artery; acquiring arterial data of the patient as a combination of longitudinal B-mode and transverse B-mode data; using a data processor to automatically recognize the artery by embedding anatomic information; using the data processor to calibrate a region of interest around the automatically recognized artery; automatically computing the weak or missing edges of intima-media and media-adventitia walls using labeling and connectivity; and determining the intima-media thickness (IMT) of an arterial wall of the automatically recognized artery.

  • ATHEROMATIC?: IMAGING BASED SYMPTOMATIC CLASSIFICATION AND CARDIOVASCULAR STROKE INDEX ESTIMATION

    Characterization of carotid atherosclerosis and classification of plaque into symptomatic or asymptomatic along with the risk score estimation are key steps necessary for allowing the vascular surgeons to decide if the patient has to definitely undergo risky treatment procedures that are needed to unblock the stenosis. This application describes a statistical (a) Computer Aided Diagnostic (CAD) technique for symptomatic versus asymptomatic plaque automated classification of carotid ultrasound images and (b) presents a cardiovascular risk score computation. We demonstrate this for longitudinal Ultrasound, CT, MR modalities and extendable to 3D carotid Ultrasound. The on-line system consists of Atherosclerotic Wall Region estimation using AtheroEdge.TM. for longitudinal Ultrasound or Athero-CTView.TM. for CT or Athero-MRView from MR. This greyscale Wall Region is then fed to a feature extraction processor which uses the combination: (a) Higher Order Spectra; (b) Discrete Wavelet Transform (DWT); (c) Texture and (d) Wall Variability. Another combination uses: (a) Local Binary Pattern; (b) Law's Mask Energy and (c) Wall Variability. The output of the Feature Processor (from either of the combination) is fed to the Classifier which is trained off-line from the Database of similar Atherosclerotic Wall Region images. The off-line Classifier using combination one is trained from the significant features from (a) Higher Order Spectra; (b) Discrete Wavelet Transform (DWT); (c) Texture and (d) Wall Variability, selected using t-test. Using the combination two, the off-line Classifier uses grayscale features: (a) Local Binary Pattern; (b) Law's Mask Energy and (c) Wall Variability. Symptomatic ground truth information about the training, patients is drawn from cross modality imaging such as CT or MR or 3D ultrasound in the form of 0 or 1. Support Vector Machine (SVM) supervised classifier of varying kernel functions is used off-line for training. The Atheromatic.TM. system is also demonstrated for Radial Basis Probabilistic Neural Network (RBPNN), or Nearest Neighbor (KNN) classifier or Decision Trees (DT) Classifier for symptomatic versus asymptomatic plaque automated classification. The obtained training parameters are then used to evaluate the test set. The system also yields the cardiovascular risk score value on the basis of the four set of wall features in combination one and risk score using combination two.

  • AUTOMATED ANALYSIS OF IMAGES USING BRIGHT FIELD MICROSCOPY

    A system and method for automatically observing and counting cells without using a stain or a fluorescent material. The system includes an optical microscope having a sensor that provides an electrical signal representative of a field of view. The microscope is motorized so as to allow automatic change of focus. A sample containing cells to be analyzed is provided. No stain or fluorescent substance is used. When the microscope is operated in a deliberately out-of-focus condition, cells appear to have either a bright or a dark spot that can be used to report the number of cells in the sample. The intensity variation detected in images acquired in different focal planes is used to identify cell shapes using image analysis software such as CellProfiler. A result is reported in any convenient format, such as a false color image.

  • SYSTEM AND METHOD FOR ACCURATE AND RAPID IDENTIFICATION OF DISEASED REGIONS ON BIOLOGICAL IMAGES WITH APPLICATIONS TO DISEASE DIAGNOSIS AND PROGNOSIS

    The present invention relates to a method and system for detecting biologically relevant structures in a hierarchical fashion, beginning at a low-resolution and proceeding to higher levels of resolution. The present invention also provides probabilistic pairwise Markov models (PPMMs) to classify these relevant structures. The invention is directed to a novel classification approach which weighs the importance of these structures. The present invention also provides a fast, efficient computer-aided detection/diagnosis (CAD) system capable of rapidly processing medical images (i.e. high throughput). The computer-aided detection/diagnosis (CAD) system of the present invention allows for rapid analysis of medical images the improving the ability to effectively detect, diagnose, and treat certain diseases.

  • AMPHIPHILIC MACROMOLECULES FOR SOLUBILIZING NANOCRYSTALS

    Certain embodiments of the invention provide amphiphilic macromolecules and nanocrystals encapsulated by amphiphilic macromolecules. Additionally, certain embodiments of the invention also provide nanocrystals that are water-solubilzed using functionalized AMs capable of coordinating to the nanocrystal surface.

  • SYSTEM AND METHOD FOR CREATING LIQUID DROPLET IMPACT FORCED COLLAPSE OF LASER NANOPARTICLE NUCLEATED CAVITIES

    A device, method and system for causing a controlled collapse of cavities formed within liquid droplets wherein a pressurized jet comprising a liquid and nanoparticle material produces droplets from the breakup of the jet stream. The liquid droplets may be irradiated with energy to produce and expand cavities formed within the droplets by irradiation of the nanoparticles contained within the droplets or alternatively, a volatile fluid with or without a metal nanoparticle may form the cavity. The droplets are collided with a target to collapse the cavities within the droplets. The irradiating (if provided) and colliding are timed to enhance implosion energy resulting from the cavities' collapse. The implosion energy and the fuel in the cavity may be used to activate and sustain a fusion reaction or from any other purposes.

  • Image projection system and method

    Provided are an image projection system and method, the image projection system including: a light source for providing illumination light; an illumination optics for receiving and illuminating the illumination light; a Spatial Light Modulator (SLM) having 2 rows of modulation devices formed to be offset from each other, each of the modulation devices modulating the light illuminated from the illumination optics; a frame scanner for scanning the modulated light from the SLM onto a screen to thereby generate a two-dimensional (2D) image corresponding to one frame on the screen; and a projection optics for projecting and focusing the modulated light transmitted from the frame scanner onto the screen.

  • Method for dynamic prior image constrained image reconstruction

    A method for reconstructing a high quality image from undersampled image data is provided. The image reconstruction method is applicable to a number of different imaging modalities. Specifically, the present invention provides an image reconstruction method that incorporates an appropriate prior image into the image reconstruction process. One aspect of the invention is to provide an image reconstruction method that produces a time series of desired images indicative of a higher temporal resolution than is ordinarily achievable with the imaging system, while mitigating undesired image artifacts. This is generally achieved by incorporating a limited amount of additional image data into the data consistency condition imposed during a prior image constrained image reconstruction. For example, cardiac phase images can be produced with high temporal resolution using a state-of-the-art multi-detector CT system with either fast gantry rotation speed or CT imaging system with a slow gantry rotation speed.

  • Method and system for registration of contrast-enhanced images with volume-preserving constraint

    A method and system for registering a first image of, for example, a liver and a second image of the liver being contrast-enhanced comprises: deriving a statistical similarity measure between images; deriving a smooth divergence-free vector field derived from a gradient of the statistical similarity measure; and integrating the vector field for providing a fluid-based algorithm including a volume-preserving constraint for a transformation for registering the images.

  • Image data processing systems

    We describe a method of determining deformation data for an imaged object, the method comprising: inputting first and second sets of image data corresponding to different deformations of the imaged object, each comprising imaging signal data for an imaging signal, said imaging signal data including at least signal phase data; and determining, for at least one point in said first set of image data, a corresponding displacement for said point in said second set of image data; wherein the displacement determining comprises: initialising a value of displacement; determining an adjusted value for said displacement to provide said corresponding displacement, said determining of an adjusted value comprising: determining an average of differences in signal phase between corresponding positions in said first and second sets of image data, said corresponding positions being determined by a current value of said displacement; and using said average to determine said adjusted displacement value.

  • Synchronized three or four-dimensional medical ultrasound imaging and measurements

    Ultrasound imaging is synchronized with measurements. Generating three-dimensional representations is synchronized with measuring one or more parameters. For example, measurements are preformed based on navigating through a volume. The measurements are linked to the corresponding three-dimensional representations. As another example, the user selects a measurement from a graph. A three-dimensional representation of the volume associated with the selected measurement is presented.

  • SVirtual surgical systems and methods

    Various embodiments of virtual surgical systems and methods are disclosed.

  • Tool tracking systems, methods and computer products for image guided surgery

    In one embodiment of the invention, a tool tracking system is disclosed including a computer usable medium having computer readable program code to receive images of video frames from at least one camera and to perform image matching of a robotic instrument to determine video pose information of the robotic instrument within the images. The tool tracking system further includes computer readable program code to provide a state-space model of a sequence of states of corrected kinematics information for accurate pose information of the robotic instrument. The state-space model receives raw kinematics information of mechanical pose information and adaptively fuses the mechanical pose information and the video pose information together to generate the sequence of states of the corrected kinematics information for the robotic instrument. Additionally disclosed are methods for image guided surgery.

  • Method of bioimage data processing for revealing more meaningful anatomic features of diseased tissues

    The present invention discloses a method for generating elevation maps or images of a tissue layer/boundary with respect to a fitted reference surface, comprising the steps of finding and segmenting a desired tissue layer/boundary; fitting a smooth reference surface to the segmented tissue layer/boundary; calculating elevations of the same or other tissue layer/boundary relative to the fitted reference surface; and generating maps of elevation relative to the fitted surface. The elevation can be displayed in various ways including three-dimensional surface renderings, topographical contour maps, contour maps, en-face color maps, and en-face grayscale maps. The elevation can also be combined and simultaneously displayed with another tissue layer/boundary dependent set of image data to provide additional information for diagnostics.

  • Method and apparatus for medical imaging using combined near-infrared optical tomography, fluorescent tomography and ultrasound

    Methods and apparatus for medical imaging using diffusive optical tomography and fluorescent diffusive optical tomography and ultrasound are disclosed. In one embodiment, the probe comprises emitters and detectors that are inclined at an angle of about 1 to about 30 degrees to a surface of the probe that contacts tissue. In another embodiment, the scanned volume is divided into an inclusion region and a background region. Different voxel sizes are used in the inclusion region and the background region. Appropriate algorithms facilitate a reconstruction of the inclusion region to determine structural and functional features of the inclusion.

  • Medical diagnostic and data processing system

    A medical diagnostic and data processing system is disclosed. The system includes, in at least one embodiment, an arithmetic logic unit and an imaging diagnostic device that can be connected to the latter for data purposes, and a data memory in which data describing anatomical structures including lymph nodes are stored. The arithmetic logic unit is set up programmatically in such a way to produce an automatic assignment between a lymph node recorded by way of the imaging diagnostic device and data describing the lymph node that are stored in the data memory.

  • Diagnostic delivery service

    Systems, methods, and other modalities are described for (a) obtaining an indication relating to an emission module (which may be dangerous, e.g.) or its user (who may be untrained, e.g.) and for (b) configuring the module or causing an irradiation (for imaging, e.g.) in response to the indication.

  • Graded resolution field of view CT scanner

    A CT scanner comprising: a rotor rotatable about an axis of rotation: an X-ray source mounted to the rotor having a focal spot from which an X-ray beam emanates; an X-ray detector array comprising a plurality of X-ray detectors for detecting X-rays in the X-ray beam; wherein the detector array has at least one high resolution region in which detectors have a high packing density and at least one low resolution region in which detectors have a low packing density and are separated by X-ray insensitive regions substantially larger than insensitive regions resulting from septa between detectors that function to reduce detector cross talk.

  • Positional magnetic resonance imaging

    A patient is examined by magnetic resonance imaging in different positions relative to gravity by moving the patient relative to the magnet, and the acquired data is compared to show differences in anatomy due to differences in patient position. Individual data elements or groups of plural data elements representing particular locations in one set of image data can be compared with data elements associated with the same locations in another set of image data, to yield a set of comparison image data elements. The comparison data set can be used to detect difference caused by differences in position of the patient.

  • Radiation imaging apparatus and method of driving the same, and radiation imaging system

    There is provided a radiation imaging apparatus delivering an output image with a satisfactory image quality irrespective of the dosage of the X-rays incident on the detector. The radiation imaging apparatus according to the present invention includes a detection unit for detecting as an image signal an X-ray irradiated from the an X-ray generation apparatus and penetrating through an object; a read out unit for amplifying and reading out the image signal detected by the detection unit; and a control unit for controlling at least one of the X-ray generation apparatus, the detection unit and the read out unit such that the obtained SN ratio of the image signal according to the dosage of the X-rays incident on the detector can be equal to the S/N ratio required for the image signal.

  • Portable radiographic imaging apparatus and radiographic image management apparatus

    There is provided a portable radiographic imaging apparatus including: an image output unit which detects a radiation which penetrates an object to be imaged and is irradiated on a surface to be irradiated of a casing, and outputs data of a radiographic image which represents a distribution of an amount of irradiated radiation; a first storage unit which stores the data of the radiographic image output from the image output unit; a display unit which displays an image; and a display control unit which allows the display unit to display a previously captured radiographic image which is associated with a current imaging, before the object to be imaged is imaged.

  • METHOD AND DEVICE FOR IMAGE QUALITY ACCREDITATION, HANDS ON CME, AND FOR CONTROL AND ANALYSIS OF ACCREDITATION AT THE ENTERPRISE LEVEL

    A method and device for accreditation of a user on an imaging device is described. The method and device can also be used for providing electronic hands-on continuing medical education credits/hours based on proficiency in generating high-quality images. In addition, other medical imaging devices, such as an ultrasound system--in which image quality is dependent on the user professional's ability--can be upgraded using the disclosed methods and devices, thereby allowing the system to automatically freeze an image if it is best-quality rated. Finally, the disclosed invention provides an analysis of accreditation at the enterprise level.

  • SKIN MARKER

    A skin marker for providing a reference point for a plurality of different medical imaging procedures, said marker incorporating one or more substances having one or more of radiance and/or hydration and/or radiopaque and/or radio luminescent and/or radioactive properties for detection by X-ray and/or Computer Tomography (CT) and/or MRI and/or Ultrasonic scanning processes and/or Positron Emission Tomography (PET), and one or more markings recognisable by an optical imaging process such as 3D surface scanning.

  • SYSTEMS AND METHODS FOR MAKING AND USING A STEERABLE IMAGING SYSTEM CONFIGURED AND ARRANGED FOR INSERTION INTO A PATIENT

    A medical imaging assembly includes a sheath with a lumen. An imaging core is disposed at one end of an imaging core shaft disposed in the lumen. The imaging core shaft bends along a shape memory region when the imaging core is extended from the lumen. The imaging core includes a transducer to image patient tissue, a mirror to redirect acoustic signals between the transducer and patient tissue, and a magnet to drive rotation of the mirror. The magnet is rotatable by a magnetic field generated at the location of the magnet. An imaging core shaft rotator rotates the imaging core shaft such that, when the imaging core is extended from the lumen, rotation of the imaging core shaft causes radial rotation of the imaging core about the sheath. The imaging core shaft rotator includes rotatable imaging core shaft magnets fixedly disposed over a portion of the imaging core shaft.

  • TRANSPARENT INK-JET RECORDING FILMS, COMPOSITIONS, AND METHODS

    Transparent ink-jet recording films, compositions, and methods are disclosed. These films exhibit high maximum optical densities and have low haze values. These films are useful for medical imaging.

  • METHOD AND APPARATUS FOR GENERATING VARIABLE RESOLUTION MEDICAL IMAGES

    A hand carried medical imaging device includes a probe configured to acquire raw medical image data, an integrated display, a data memory configured to store the acquired raw medical image data, a back end processor, and a user interface operably coupled to the back end processor configured to receive commands from a user and to instruct the back end processor to display the produced medical image on the integrated display at a first resolution, and to either produce and send either the medical image at the second, higher resolution, to send the acquired raw image data, or both, to the external device, in accordance with the commands from the user.

  • System for image scanning and acquisition with low-dose radiation

    A medical imaging system adaptively acquires anatomical images using a shape adaptive collimator including multiple different portions of X-ray absorbent material automatically adjustable to alter the dimensions of a spatial cross section of an X-ray beam of radiation into a non-rectangular shape, in response to a control signal. The synchronization processor provides a heart rate related synchronization signal derived from a patient cardiac function related parameter. The synchronization signal enables adaptive variation in timing of image acquisition within an individual heart cycle and between successive heart cycles of each individual image frame of multiple sequential image frames. The X-ray image acquisition device uses the shape adaptive collimator for acquiring anatomical images of the region of interest with reduced patient X-ray exposure in response to the synchronization signal. A display processor presents resultant images.

  • TRANSPARENT INK-JET RECORDING FILMS, COMPOSITIONS, AND METHODS

    Transparent ink jet recording films, compositions, and methods are disclosed. These films have improved appearance compared to other similar high optical density films. Such improved appearance films are produced without requiring reduced drying process throughput. These films are useful for medical imaging.

  • Method and Apparatus Regarding Iterative Processes as Pertain to Medical Imaging Information

    A medical-imaging digital-computing platform serves to access a plurality of data objects and to execute an iterative process with respect to these data objects. The data objects themselves each at least generally pertain to portions of the human anatomy and may comprise, for example, both a source data object and a target data object. The platform executes the iterative process to determine at least one of a labeling of a portion of one of the data objects and a geometric relationship between at least portions of at least two of the data objects. This can be done, for example, by automatically employing both a segmentation module and a registration module as steps within the iterative process. This can also comprise determining when to automatically generate an intermediate data object to provide as input to at least one of these modules.

  • Thick targets for transmission x-ray tubes

    This invention relates to the use of thick target materials 50 microns and thicker for an x-ray transmission tube; to possible target material compositions including various elements and their alloys, eutectic alloys, compounds, or intermetallic compounds; and applications for utilizing such thick target transmission x-ray tubes. The target comprises at lease one portion of the target with a thickness of 50 microns or greater. The target can be optionally attached to a substrate end-window essentially transparent to x-rays or be thick enough so that no such substrate is required. Applications include producing a high percentage of monochromatic line mission x-rays of said thick target for use in reduced dose medical imaging and other non-destructive testing applications.

  • SYSTEM AND METHODS FOR PROVIDING INFORMATION RELATED TO A TISSUE REGION OF A SUBJECT

    A system for providing information related to a tissue region of a patient is provided. The system includes a user interface configured for co-displaying medical imaging information of the tissue region and visible light information of the tissue region.

  • METHOD AND SYSTEM FOR IMAGING PATIENTS WITH A PERSONAL MEDICAL DEVICE

    A method and system are provided for detecting the presence of a personal medical device within a patient. A method and system are provided for determining the location and type of the personal medical device as well as other characteristics of the device. A method and system are provided for adapting or customizing amedical imaging procedure to avoid interfering with a personal medical device or to diminish the risk of device interference or malfunction. A method and system are provided for interfacing with health record databases, regulatory databases, medical device databases, or other types of databases to gather information regarding a particular patient's personal medical device and to update said databases with additional information regarding the personal medical device if any is gathered.

  • Medical Imaging Device

    A medical imaging device having a tubular receiving region to receive a patient on a patient couch is proposed. The medical imaging device has a wall at least partially enclosing the receiving region. The medical imaging device features a film disposed on the wall at least partially enclosing the receiving region for generating at least one virtual image. The virtual image refers to a visual mapping of a light-reflecting object and/or an illuminated object.

  • TRANSPARENT INK-JET RECORDING FILMS, COMPOSITIONS, AND METHODS

    Transparent ink jet recording films, compositions, and methods are disclosed. Such films exhibit improved ink-drying and smudging performance. These films exhibit high maximum optical densities and have low haze values. These films are useful for medical imaging.

  • IMAGE PROCESSING METHOD TO DETERMINE SUSPECT REGIONS IN A TISSUE MATRIX, AND USE THEREOF FOR 3D NAVIGATION THROUGH THE TISSUE MATRIX

    A method to generate a final image with a medical imaging system, wherein the final image highlights suspect regions in a tissue matrix and wherein the final image is generated from a first image and from previously acquired images of the tissue matrix is provided. The method comprises: creating a 3D map of suspicion from the previously acquired medical images; generating a 2D map of suspicion by projecting all or part of the 3D map of suspicion onto a plane from a point reproducing the conditions of acquisition of the first image; and generating a final 2D image of the tissue matrix from the first image and/or from the 2D map of suspicion, wherein the final 2D image highlights suspect regions in the tissue matrix.

  • PRETARGETING KIT, METHOD AND AGENTS USED THEREIN

    Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an alkene or alkyne dienohile.

  • Initiating a Scan in a Medical Imaging System

    A method of initiating a scan in a medical imaging device includes detecting a patient-ready signal from a magnetically and radiographically inert communication device and automatically initiating the scan upon detecting the patient-ready signal.

  • Dual Constrained Methodology for IMT Measurement

    A computer-implemented system and method for intima-media thickness (IMT) measurements using a validation embedded segmentation method. Various embodiments include receiving biomedical imaging data and patient demographic data corresponding to a current scan of a patient; checking the biomedical imaging data in real-time to determine if an artery of the patient has a atherosclerosis deposit in a proximal wall of the artery; acquiring arterial data of the patient as a combination of longitudinal B-mode or M-mode and transverse B-mode or M-mode data; using a data processor to automatically recognize the artery by embedding anatomic information; using the data processor to calibrate a region of interest around the automatically recognized artery; automatically computing the lumen intima and media-adventita borders by evolving the initial lumen intima and initial media-adventita borders constrained by distances based on polyline method or centerline method; and determining the intima-media thickness (IMT) of an arterial wall of the automatically recognized artery.

  • SYSTEMS AND METHODS FOR TEMPORAL MULTIPLEXING X-RAY IMAGING

    The present subject matter relates to systems and methods for temporal multiplexing x-ray imaging of dynamic objects with high temporal resolution and fast imaging speed. A pulsed x-ray beam can irradiate an object undergoing a range of motion such as a cyclic motion. Multiple x-ray images can be acquired at different phases within a single motion cycle or range of the object. The multiple x-ray images can be demultiplexed to produce an individual phase image. Compared to sequential imaging, temporal multiplexing x-ray imaging can achieve high temporal resolution of dynamics object in multiple phases with imaging time comparable to that of a single phase. Temporal multiplexing x-ray imaging can thus be applied to a wide variety of applications, including biomedical imaging and industrial non-destructive testing.

  • COLLIMATION APPARATUS FOR HIGH RESOLUTION IMAGING

    The invention relates to a collimation apparatus for use in biomedical imaging systems. Specifically, the invention relates to a collimation apparatus that blocks a portion of its crystal with a radiation blocking element.

  • IMAGE-BASED RISK SCORE-A PROGNOSTIC PREDICTOR OF SURVIVAL AND OUTCOME FROM DIGITAL HISTOPATHOLOGY

    The present invention relates to an image-based computer-aided prognosis (CAP) system and method that seeks to replicate the prognostic power of molecular assays in histopathology and pathological processes, including but not limited to cancer. Using only a tissue slide samples, a mechanism for digital slide scanning, and a computer, the present invention relates to an image-based CAP system and method which aims to overcome many of the drawbacks associated with prognostic molecular assays (e.g. Oncotype DX) including the high cost associated with the assay, limited laboratory facilities with specialized equipment, and length of time between biopsy and prognostic prediction.

  • SYSTEM, METHOD, AND LUMINESCENT MARKER FOR IMPROVED DIFFUSE LUMINESCENT IMAGING OR TOMOGRAPHY IN SCATTERING MEDIA

    A method and system for luminescence molecular imaging or tomography of a region of interest in a scattering medium is disclosed. The system comprises a non-linear luminescent marker material arranged in the scattering medium. Contrast and resolution of the imaging or tomography is thus improved. The non-linear marker is for instance configured to upconvert incoming light of an illumination wavelength. The non-linear power dependence of the marker enables further improvement of the imaging by using images taken with two or more excitation beams simultaneously.

  • Production of Optical Pulses At A Desired Wavelength Utilizing Higher-Order-Mode (HOM) Fiber

    An apparatus and method for producing optical pulses of a desired wavelength utilizes a section of higher-order-mode (HOM) fiber to receive input optical pulses at a first wavelength, and thereafter produce output optical pulses at the desired wavelength through soliton self-frequency shifting (SSFS) or Cherenkov radiation. The HOM fiber is configured to exhibit a large positive dispersion and effective area at wavelengths less than 1300 nm.

  • Imaging Based Symptomatic Classification Using a Combination of Trace Transform, Fuzzy Technique and Multitude of Features

    A statistical (a) Computer Aided Diagnostic (CAD) technique is described for symptomatic versus asymptomatic plaque automated classification of carotid ultrasound images and (b) presents a cardiovascular risk score computation. We demonstrate this for longitudinal Ultrasound, CT, MR modalities and extendable to 3D carotid Ultrasound. The on-line system consists of Atherosclerotic Wall Region estimation using AtheroEdge.TM. for longitudinal Ultrasound or Athero-CTView.TM. for CT or Athero-MRView from MR. This greyscale Wall Region is then fed to a feature extraction processor which uses the combination: (a) Higher Order Spectra; (b) Discrete Wavelet Transform (DWT); (c) Texture and (d) Wall Variability. Another combination uses: (a) Local Binary Pattern; (b) Law's Mask Energy and (c) Wall Variability. Another combination uses: (a) Trace Transform; (b) Fuzzy Grayscale Level Co-occurrence Matrix and (c) Wall Variability. The output of the Feature Processor is fed to the Classifier which is trained off-line.

  • Method of Analysis for Dynamic Magnetic Resonance Perfusion Imaging

    A method (100) of processing myocardial MR perfusion images that corrects imaging errors arising from myocardial motion and B-1 field inhomogeneity (115-135); segments the myocardium images (140, 145); and calculates perfusion measures that enable analysis of the segmented myocardium images (150).

  • EXACT LOCAL COMPUTED TOMOGRAPHY BASED ON COMPRESSIVE SAMPLING

    A system and method for tomographic image reconstruction using truncated projection data that allows exact interior reconstruction (interior tomography) of a region of interest (ROI) based on the known sparsity models of the ROI, thereby improving image quality while reducing radiation dosage. In addition, the method includes parallel interior tomography using multiple sources beamed at multiple angles through an ROI and that enables higher temporal resolution.

  • Dual Constrained Methodology for IMT Measurement

    A computer-implemented system and method for intima-media thickness (IMT) measurements using a validation embedded segmentation method. Various embodiments include receiving biomedical imaging data and patient demographic data corresponding to a current scan of a patient; checking the biomedical imaging data in real-time to determine if an artery of the patient has a atherosclerosis deposit in a proximal wall of the artery; acquiring arterial data of the patient as a combination of longitudinal B-mode or M-mode and transverse B-mode or M-mode data; using a data processor to automatically recognize the artery by embedding anatomic information; using the data processor to calibrate a region of interest around the automatically recognized artery; automatically computing the lumen intima and media-adventita borders by evolving the initial lumen intima and initial media-adventita borders constrained by distances based on polyline method or centerline method; and determining the intima-media thickness (IMT) of an arterial wall of the automatically recognized artery.

  • Diaza Heterocyclic Compounds for Phototherapy

    The invention relates generally to optical agents, including phototherapeutic agents, for biomedical applications, including phototherapy. The invention includes optical agents, and related therapeutic methods, comprising alicyclic diaza compounds, including 1,2 diaza heterocyclic compounds, having a photolabile N--N bond directly or indirectly linked to at least one carbocyclic aromatic and/or heterocyclic aromatic group. In some embodiments, for example, the invention provides alicyclic diaza compounds for phototherapeutic methods having a photolabile N--N bond that undergoes photoactivated cleavage to produce reactive species, such as radicals, ions, etc., that achieve a desired therapeutic effect, such as selective and/or localized tissue damage and/or cell death.

  • COLLIMATION APPARATUS FOR HIGH RESOLUTION IMAGING

    The invention relates to a collimation apparatus for use in biomedical imaging systems. Specifically, the invention relates to a collimation apparatus that blocks a portion of its crystal with a radiation blocking element.

  • Compounds Containing Acyclic N-N Bonds for Phototherapy

    The invention relates generally to optical agents for biomedical applications, including phototherapy. The invention includes optical agents, and related therapeutic methods, comprising compounds with an acyclic N--N bond having at least one aromatic and/or heterocyclic aromatic group providing phototherapeutic agents, including Type 1 phototherapeutic agents. In some embodiments, for example, the invention provides compounds for phototherapeutic methods having one or more photolabile acyclic N--N bonds capable of undergoing photoactivated cleavage to produce reactive species, such as radicals, ions, etc., that achieve a desired therapeutic effect, such as selective and/or localized tissue damage and/or cell death.

  • MRI Markers, Delivery and Extraction Systems, and Methods of Manufacture and Use Thereof

    Novel, non-toxic cobalt-based contrast and imaging agents for use in enhanced medical imaging modalities and processes are described, as well the manufacture of markers containing such contrast agents is described, and uses for such imaging markers and contrast agents in a variety of therapeutic applications and devices.

  • Endless flexible members with a polymeric release agent for imaging devices

    Flexible members for use in imaging devices comprise a polymerizable release agent.

  • SPECTRAL MAGNETIC PARTICLE IMAGING

    The invention relates to the discrimination of spectroscopically different tracer materials by magnetic particle imaging (MPI), based on the differences of the MPI spectral responses of said tracer materials.

  • NANOCARRIERS FOR IMAGING AND THERAPY APPLICATIONS

    Nanocarriers and methods of preparation and use of nanocarriers are presented. In some embodiments, a nanocarrier composition comprises an organic liquid comprising a plurality of nanoparticles dispersed therein; and a coating material disposed around the exterior surface of the organic liquid. Biological tissue may be imaged or treated by coming into contact with a nanocarrier composition, and, at least in some embodiments, irradiated.

  • Vasculature and lymphatic system imaging and ablation

    Devices, methods, and systems related to imaging and ablation are disclosed.

  • METHOD FOR COMBINED IMAGING AND TREATING ORGANS AND TISSUES

    The present invention provides methods and compositions for detecting and treating malignant tissue, organs or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus or by a route providing access to the tissue or organ, with a composition comprising a monoclonal antibody (chimeric, humanized, fully human), partial antibody, Fab Fragment, antibody fragment that is tagged with a fluorophore with or without the addition of a therapeutic chemotherapy molecule, which specifically binds to the targeted organ, tissue or cell. Resection of the primary malignant tissue within the mammalian species (using the fluorescence of the fluorescing targeting construct) provides the advantage of identifying all bulk tumor as fluorescent at the time of the original tumor resection.

  • Intraoral Imaging Devices And Methods

    Disclosed is an intraoral imaging method that includes providing an intraoral imaging device having at least one biteplate including a dental impression material and a track, at least one carriage assembly that travels along at least a portion of the track, and imaging equipment which is secured to the at least one carriage assembly; locating the at least one biteplate between upper and lower teeth of the subject such that the dental impression material cooperates with at least one of the upper and lower teeth to provide repeatable registration within an oral cavity of the subject; and obtaining image data using the imaging equipment.

  • ALL-PROTEIN IMPLANTABLE, RESORBABLE REFLECTORS

    The invention provides for compositions and process for fabricating an optical reflector constructed from biocompatible and bioresorbable silk fibroin proteins. For example, the silk retroreflectors may be built based on millimeter size microprism arrays to rotate the image plane of imaged cortical layers, thus enhancing the amount of photons that are detectable in the reflected direction when inserted in a sample to be analyzed, and ultimately increasing in contrast ratio in multiphoton microscopy. Such device can be used as a label-free, biocompatible, bioresorbable, implantable device for various applications ranging from medical imaging/diagnostics, drug/therapeutic delivery, to food chain safety and environmental monitoring.

  • METHOD AND APPARATUS FOR BIOMETRIC ANALYSIS USING EEG AND EMG SIGNALS

    Biometric assessment is performed by use of electromyography (EMG) signals detected from muscles at several locations on the hand/or other part of the body subject to fine motor control. In addition,electroencephalography (EEG), signals detect other biomarkers. The EMG and EEG signals are sensed, synchronized and registered. The signals are converted into digital data and are stored and processed for use in performing the biometric assessment.

  • Method and Apparatus for Compressive Imaging Device

    A new digital image/video camera that directly acquires random projections of the incident light field without first collecting the pixels/voxels. In one preferred embodiment, the camera employs a digital micromirror array to perform optical calculations of linear projections of an image onto pseudorandom binary patterns. Its hallmarks include the ability to obtain an image with only a single detection element while measuring the image/video fewer times than the number of pixels or voxels--this can significantly reduce the computation required for image/video acquisition/encoding. Since the system features a single photon detector, it can also be adapted to image at wavelengths that are currently impossible with conventional CCD and CMOS imagers.

  • IMAGING PRODUCT SELECTION METHOD

    A method for displaying a collage of digital images on a display, receiving a selection for one of the digital images to be presented on a separate area of the display together with any associated multimedia, wherein one of the digital images has a portion overlapped by another digital image.

  • IMAGING-CONTROLLED LASER SURGICAL SYSTEM

    An imaging-based laser system can include a laser-beam system, configured to generate and scan a beam of laser pulses with an adjustable laser-power parameter to points of a scan-pattern in an eye, and an imaging-based laser-controller, configured to image a layer in the eye, to control the scanning of the beam of laser pulses to the points of the scan-pattern, and to control a laser-power parameter of the laser pulses according to the distance of the points of the scan-pattern from the imaged layer.

  • Ultrasound Imaging System Using Beamforming Techniques for Phase Coherence Grating Lobe Suppression

    High-frequency ultrasound imaging can be performed with greater quality and suppressed grating lobes by using methods and systems for effectively reducing the temporal length of transmit grating lobe signals in received ultrasound echoes. Systems and methods are provided for improved high-frequency ultrasound imaging. In various aspects, the method of shortening the time domain of grating lobe signals comprises splitting an array of N transmit elements into K sub-apertures. In further aspects, the grating lobes are suppressed by performing signal processing of the shortened grating lobe signals. In certain aspects, the signal processing method comprises weighting the samples by a calculated phase coherence factor.

  • ULTRASONIC IMAGING DEVICE AND INFORMATION PROCESSING DEVICE

    Provided is an ultrasonic imaging device that noninvasively measures the stiffness of the cardiac muscle, which is the heart muscle, or intracardiac pressure, which is the blood pressure inside the heart. The ultrasonic imaging device includes: an ultrasonic probe (2) that transmits and receives ultrasonic waves to and from the heart, which is the target organ inside the body; a signal-processing section (15) that processes reflected echo signals received by the ultrasonic probe; a display section (14) that displays the results of signal processing as an image; and an input section (10) for setting a predetermined point on the image displayed on the display section. The signal-processing section (15) includes: a shape-extracting section (152) that perceives information on the shape of the heart from the reflected echo signals; a natural-frequency detecting section (153) that detects the natural frequency of the heart from the reflected echo signals; and a calculating section (154) that calculates the stiffness of the cardiac muscle or the intracardiac pressure, wherein the calculating section (154) accurately calculates the stiffness of the cardiac muscle from the natural frequency of the heart and calculates the intracardiac pressure from the stiffness of the cardiac muscle that has been calculated.

  • Multi-Modality Ultrasound and Radio Frequency System for Imaging Tissue

    This invention provides a dual-modality system for performing characterization and imaging of tissue, tumors, structures, lesions, and ablations under investigation. Specifically, the invention couples ultrasound technology comprising at least two focused ultrasound beams for vibrating target tissues located at the focal point of the ultrasound beams intersection with a radio frequency system for measuring the response of the target tissues. The ultrasound system vibrates the target tissues while the reflected radio frequency energy is transmitted into the target tissues. When reflected, the main carrier tone of the reflected radio frequency energy is cancelled and analysis is performed on the remaining sideband frequencies.

  • ENDOSCOPIC IMAGING DEVICE

    An endoscopic imaging device for endoscopy in a body vessel is disclosed. The device comprises an annular illumination tube comprising an annular illumination fiber for illuminating a body vessel during endoscopy. The device further includes a first imaging tube comprising a first imaging fiber for gross examination and navigation through the body vessel. The first imaging fiber is disposed within the annular illumination tube. The device further comprises a second imaging tube comprising a second imaging fiber for cellular imaging. The second illumination fiber is disposed adjacent the first imaging tube and within the annular illumination tube.

  • System and Method for Hybrid Radiofrequency Labeling for Magnetic Resonance Imaging

    A system and method is provided for magnetic resonance angiography (MRA) that includes applying a first labeling pulse sequence to a first labeling region having a first portion of a vasculature of a subject extending through the first labeling region to label spins moving within the first labeling region. A second labeling pulse sequence is applied to a second labeling region having a second portion of a vasculature of the subject extending through the second labeling region to label spins moving within the second labeling region. The first and second labeling pulse sequences include different labeling techniques. An imaging pulse sequence is applied to an imaging region having a third portion of a vasculature of the subject extending through the imaging region that is displaced from the first and second labeling region to acquire imaging data from the spins labeled by the first labeling pulse sequence and the second labeling pulse sequence. An MRA image is reconstructed of at least the third portion of the vasculature of the subject from the medical imaging data.

  • PHOTOACOUSTIC IMAGING APPARATUS AND PHOTOACOUSTIC IMAGING METHOD

    The present invention provides a photoacoustic imaging apparatus, having: a light source; a plurality of detecting elements for detecting an acoustic wave generated from a surface of an object and a light absorber inside the object, and converting the acoustic wave into a detection signal; and a signal processor for generating image data based on detection signals detected, wherein the signal processor has: a Fourier transformer for performing Fourier transform, in a spatial direction, on the signals detected at a same receiving time so as to obtain spatial frequency signals; and an inverse-Fourier transformer for performing inverse Fourier-transform after reducing components exhibiting less than a predetermined frequency from among the spatial frequency signals so as to obtain second signals, the signal processor generating image data using the second signals.

  • CXCR4 ANTAGONISTS FOR IMAGING OF CANCER AND INFLAMMATORY DISORDERS

    The invention provides radiolabeled CXCR4 antagonists, compositions and methods of use for imaging of chemokine CXCR4 receptors and biological conditions associated with the expression of CXCR4 receptors, including cancer, metastasis, and inflammatory disorders.

  • IMAGING APPARATUS, LIGHT EMITTING DEVICE, IMAGING SYSTEM, AND CONTROL METHOD

    An imaging apparatus including a light emitting device includes a determination unit configured to determine a weighting coefficient of each of a plurality of light metering regions, a calculation unit configured to calculate an amount of main flash light of the light emitting device after performing weighting of the light metering value of each of the plurality of light metering regions according to the weighting coefficient determined by the determination unit, and a selection unit configured to select, from the plurality of light metering regions, a reference region which is used when the weighting coefficient of each of the plurality of light metering regions is determined by the determination unit, and the selection unit selects the reference region in such a manner that a light metering region different from a light metering region whose color information acquired by the color information acquisition unit satisfies a particular condition, is preferentially selected.

  • SYSTEM AND METHODS OF COMPRESSED SENSING AS APPLIED TO COMPUTER GRAPHICS AND COMPUTER IMAGING

    Compressed sensing can be mapped to a more general set of problems in computer graphics and computer imaging. Representation of a rendered scene in the formulation y=A x produces higher-quality rendering with less samples than previous approaches. A filter formulation .PHI. makes point samples compatible with wavelet and therefore allows reconstruction of 2-D images from a set of measured pixels (point samples).

  • IMAGE PROCESSING APPARATUS, IMAGE PROCESSING METHOD, PROGRAM AND IMAGING APPARATUS

    Provided is an image processing apparatus, including an extraction color region determination unit which performs a process of determining an extraction color region including at least a partial region in an image using color information of an input image signal, and an image processing unit which performs image processing on the extraction color region of the input image signal determined by the extraction color region determination unit and/or the remaining region of the input image signal excluding the extraction color region, to obtain an output image signal

  • CONTRAST IMPROVEMENT METHOD AND SYSTEM FOR PHOTOACOUSTIC IMAGING

    A contrast improvement method and system for photoacoustic imaging decomposes a photoacoustic image into a plurality of subband images using a set of filters, and integrates the subband images to form an integrated image. The subband images may be pseudo colored and weighted to improve contrast of the photoacoustic image.

  • OPHTHALMOLOGIC IMAGING APPARATUS

    Provided is an ophthalmologic imaging apparatus suppressing the effect of a motion artifact caused by a movement of an eye to be inspected, comprising: a scanning unit for scanning, with first and second measuring beams, at least a part of an overlap area of scan areas thereof in an inspected eye, at different times, respectively; an image acquiring unit for acquiring first and second images of the inspected eye based on first and second return beams resulting from the first and second measuring beams being applied via the scanning unit and reflected by the inspected eye; an identification unit for identifying an image including a motion artifact from each of the first and second images; and an image forming unit for forming an image of the inspected eye based on the first and second images other than the images identified by the identification unit.

  • POWER CONVERTER, X-RAY CT APPARATUS, AND X-RAY IMAGING APPARATUS

    In order to prevent breakage of a power converter, a current which flows into an inverter (3) in the power converter is detected. The inverter (3) is equipped with two or more primary windings in parallel with each other. The current flowing through each of the primary windings is detected by current sensors (17, 6). A control unit (22) determines from the outputs of the current sensors that an abnormality occurs, when current does not flow through any of the primary windings.

  • ANALYZING METHOD OF PHASE INFORMATION, ANALYZING PROGRAM OF THE PHASE INFORMATION, STORAGE MEDIUM, AND X-RAY IMAGINGAPPARATUS

    An analyzing method for deriving phase information by analyzing a periodic pattern of moire comprises steps of: subjecting at least a part of the periodic pattern of moire to a windowed Fourier transform by a window function; calculating analytically, based on the moire subjected to the windowed Fourier transform, information of a first spectrum carrying the phase information, and information of a second spectrum superimposed on the information of the first spectrum; and separating the information of the first spectrum from the information of the second spectrum, to derive the phase information.

  • X-RAY IMAGING APPARATUS AND X-RAY IMAGING METHOD

    An X-ray imaging apparatus acquiring a differential phase contrast image of a test object without using a light-shielding mask for X-ray. The apparatus includes an X-ray source, a splitting element configured to spatially divide an X-ray emitted from an X-ray source and a scintillator configured to emit light when a divided X-ray beam divided at the splitting element is incident on the scintillator. The apparatus also includes a light-transmission limiting unit configured to limit transmitting amount of the light emitted from the scintillator and a plurality of light detectors each configured to detect the amount of light that has transmitted through the light-transmission limiting unit. The light-transmission limiting unit is configured such that a light intensity detected at each of the light detectors changes in response to a change in an incident position of the X-ray beam.

  • DISPLAY OF ANTIBODY FRAGMENTS ON VIRUS-LIKE PARTICLES OF RNA BACTERIOPHAGES

    The invention enables the display of antibody single-chain variable fragments (scFv's on virus-like particles (VLPs) of bacteriophages such as MS2. The VLPs encapsidate mRNA encoding the coat protein from which it assembles, enabling the recovery by reverse transcription and PGR of affinity-selected sequences from scFv libraries. Related virus-like particles, method for constructing a library of scFv-VLPs, drug delivery vehicles comprising one or more pharmaceutically-active ingredients, biomedical imaging agents, assays, and kits are also provided.

  • HYPERSPECTRAL IMAGING SYSTEMS AND RELATED METHODS

    Systems and methods for analyzing sublingual microcirculation perfusion and identifying particular nerve tracts. In exemplary embodiments, a digital micro-mirror device is configured to direct a reflected light to a subject area and a controller is configured to alter a parameter of the reflected light.

  • BIMODAL STAR POLYMER ARCHITECTURES AS FLUORESCENT AND MRI IMAGING REAGENTS

    Disclosed are star polymers comprising a polymeric body having a core with a site-isolated chromophore and a plurality of polymer chains emanating from the core; and at least one chelating moiety bonded to at least one polymer chain. Also disclosed are bimodal contrast agents derived from star polymers and further comprising at least one metal chelated by the at least one chelating moiety. Also disclosed are methods of making and using same. Also disclosed are imaging methods employing the disclosed star polymers and/or bimodal contrast agents. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  • DIFFERENTIAL PHASE CONTRAST X-RAY IMAGING SYSTEM AND COMPONENTS

    A differential phase contrast X-ray imaging system includes an X-ray illumination system, a beam splitter arranged in an optical path of the X-ray illumination system, and a detection system arranged in an optical path to detect X-rays after passing through the beam splitter.

  • Medical and Imaging Nanoclusters

    In one embodiment the present invention discloses a nanocluster or a nanorose composition comprising two or more closely spaced nanoparticles each comprising one or more metals, metal oxides, inorganic substances, or a combination thereof and one or more stabilizers. The stabilizers are in contact with the two or more closely spaced nanoparticles to form a nanocluster composition in which the inorganic weight percentage is greater than 50% and the average size is below 300 nm, and the nanocluster composition has magnetic properties, optical properties or a combination of both.

  • FAST TOMOGRAPHIC MICROWAVE IMAGING

    Microwave imaging equipment utilizing an array of antennas operated to collect electromagnetic field information for a material being imaged. Image processing method and apparatus use the discrete dipole approximation (DDA) and drastically reduce the time required to process the measured data and estimate the properties of the material. Prior to interrogating the material, interaction matrices are generated and stored for future DDA calculations. The interaction matrices relate to the interaction between the antennas, the operating frequency, the background medium, and the location of the discretizing dipoles. An initial guess of the material properties is made and the resultant field is estimated. These results are compared to the measured results and incremental changes in the material property are computed. The updated material properties are used to recalculate the field. Comparison of the field to the measured field and updating of the material properties continues until an end criterion is satisfied.

  • Imaging Catheter With Integrated Reference Reflector

    In part, the invention relates to a lens assembly. The lens assembly includes a micro-lens; a beam director in optical communication with the micro-lens; and a substantially transparent film. The substantially transparent film is capable of bi-directionally transmitting light, and generating a controlled amount of backscatter. In addition, the film surrounds a portion of the beam director.

  • SYSTEM AND METHOD FOR SUB-SURFACE FLUORESCENCE IMAGING

    Methods for quantifying fluorescence and optical properties in a turbid medium such as tissue. Devices and systems suitable for the methods are also disclosed.

  • DIFFERENTIAL PHASE CONTRAST X-RAY IMAGING SYSTEM AND COMPONENTS

    A differential phase contrast X-ray imaging system includes an X-ray illumination system, a beam splitter arranged in an optical path of the X-ray illumination system, and a detection system arranged in an optical path to detect X-rays after passing through the beam splitter.

  • METHOD OF PERFORMING MRI WITH AN ATOMIC MAGNETOMETER

    A method and apparatus are provided for performing an in-situ magnetic resonance imaging of an object. The method includes the steps of providing an atomic magnetometer, coupling a magnetic field generated by magnetically resonating samples of the object through a flux transformer to the atomic magnetometer and measuring a magnetic resonance of the atomic magnetometer.

  • GENERATING FREE VIEWPOINT VIDEO USING STEREO IMAGING

    Methods and systems for generating free viewpoint video using an active infrared (IR) stereo module are provided. The method includes computing a depth map for a scene using an active IR stereo module. The depth map may be computed by projecting an IR dot pattern onto the scene, capturing stereo images from each of two or more synchronized IR cameras, detecting dots within the stereo images, computing feature descriptors corresponding to the dots in the stereo images, computing a disparity map between the stereo images, and generating the depth map using the disparity map. The method also includes generating a point cloud for the scene using the depth map, generating a mesh of the point cloud, and generating a projective texture map for the scene from the mesh of the point cloud. The method further includes generating the video for the scene using the projective texture map.

  • Light Refraction Imaging to Measure Liquid Volume

    A method to measure the volume of fluid present that relies on the pattern of light refraction as it passes though an airway surface liquid (ASL) meniscus. The method comprises allowing epithelial cells to grow on a membrane in a well so as to form a fluid meniscus about the perimeter of the well. The well is then illuminated by a light source. The illuminated cells in the well are then optically imaged by a scanner, a flat bed optical scanner, a camera, or any device capable of imaging. Microscopy may be used but is not needed, and high powered microscopy is certainly not needed. Then the imaging information from the cells in the well is used to determine a property of the meniscus in the well. Specifically, the imaging information can be analyzed to determine the dimensions, shape, and/or volume of the meniscus and the fluid in the well.

  • STRUCTURAL ILLUMINATION AND EVANESCENT COUPLING FOR THE EXTENSION OF IMAGING INTERFEROMETRIC MICROSCOPY

    In accordance with the aspects of the present disclosure, a method and apparatus is disclosed for imaging interferometric microscopy (IIM), which can use an immersion medium to enhance resolution up to a resolution of linear systems resolution limit of .lamda./4n, where .lamda. is the wavelength in free space and n is the index of refraction of a transmission medium

  • IMAGING SYSTEMS AND METHODS FOR RECOVERING OBJECT VISIBILITY

    A system and method are provided for imaging in scattering media such as fog, water and biological tissues. Normally, such images suffer from poor visibility due to backscattering and signal attenuation. At least two images are taken of the scene using active widefield polarized illumination, with different states of a camera-mounted polarizer. The degree of polarization of backscatter is estimated in every point of the scene, leading to an estimation of the backscatter in every point of the scene. A portion or all of the value of backscatter can be deducted in each point of the scene resulting in an enhanced image with improved contrast and brightness range across the field of view.

  • IMAGING SYSTEM FOR VEHICLE

    An imaging system for a vehicle includes an imaging device having a forward field of view exterior of the vehicle. The imaging device is operable to capture multiple frames of image data, and the multiple frames of image data include repeating frame sets. A particular frame set of the repeating frame sets has at least two frames. An image processor operable to process image data captured by the imaging device. A control, responsive to processing of captured image data, controls, at least in part, an intelligent headlamp control feature of the vehicle and a lane departure warning feature of the vehicle. One frame of a particular frame set is processed by the image processor for the intelligent headlamp control feature and no other frame of the particular frame set is processed by the image processor for the intelligent headlamp control feature.

  • WIDE-FIELD LENSLESS FLUORESCENT IMAGING ON A CHIP

    An imaging device uses a fiber optic faceplate (FOF) with a compressive sampling algorithm for the fluorescent imaging of a sample over an large field-of-view without the need for any lenses or mechanical scanning. The imaging device includes a sample holder configured to hold a sample and a prism or hemispherical glass surface disposed adjacent the sample holder on a side opposite the lower surface of the sample holder. A light source is configured to illuminate the sample via the prism or the hemispherical surface, wherein substantially all of the light is subject to total internal reflection at the lower surface of the sample holder. The FOF is disposed adjacent to the lower surface of the sample holder, the fiber optic array having an input side and an output side. The device includes an imaging sensor array disposed adjacent to the output side of the fiber optic array.

  • SEMI-AUTOMATED OR FULLY AUTOMATED, NETWORK AND/OR WEB-BASED, 3D AND/OR 4D IMAGING OF ANATOMY FOR TRAINING, REHEARSING AND/OR CONDUCTING MEDICAL PROCEDURES, USING MULTIPLE STANDARD X-RAY AND/OR OTHER IMAGING PROJECTIONS, WITHOUT A NEED FOR SPECIAL HARDWARE AND/OR SYSTEMS AND/OR PRE-PROCESSING/ANALYSIS OF A CAPTURED IMAGE DATA

    Systems, methods and software are provided that simulate or facilitate imaging of medical procedures for purposes of optimized performance, simulation, training and/or accreditation. More particularly, aspects of the invention relate to a system, apparatus and/or subsystems for generating 3D and/or 4D imaging from 2 or more 2D images and/or projections for use in performing, simulating, training, and/or facilitating medical-access procedures. Such procedures use semi-automated and/or fully automated, network and/or web-based, 3D and/or 4D imaging of anatomy and corresponding medical devices or treatment for performing, training, rehearsing and/or conducting medical procedures, using multiple (e.g., >2 and/or >3) standard 2D x-ray and/or other radiation or sound imaging projections without a need for special hardware and/or systems (e.g., rotational runs) and/or pre-processing/analysis of a captured image data.

  • Optical Imaging System and Method, and Aperture Stop Assembly and Aperture Element

    An optical imaging system includes a birefringent element, a light modulating element, and a polarizer element. The birefringent element is configured for decomposing un-polarized light into first linear polarized light and second linear polarized light under different refractive indexes to respectively form a first focal length and a second focal length in the optical imaging system. The light modulating element is configured for modulating a state of polarization of the first and second linear polarized light in response to control signals. The polarizer element is configured for filtering out one of the modulated first and second linear polarized light for creating a single image.

  • SYSTEMS AND METHODS FOR VIEWING MEDICAL 3D IMAGING VOLUMES

    A method of automatically tracking the portions of a 3D medical imaging volume, such as the voxels, that have already been displayed according to use-defined display parameters, notating those portions, and providing the user with information indicating what portions of the imaging volume have been displayed at full resolution.

  • ABRASIVE TOOL FOR USE AS A CHEMICAL MECHANICAL PLANARIZATION PAD CONDITIONER

    An abrasive tool including a CMP pad conditioner having a substrate including a first major surface, a second major surface opposite the first major surface, and a side surface extending between the first major surface and the second major, wherein a first layer of abrasive grains is attached to the first major surface and a second layer of abrasive grains is attached to the second major surface. The conditioner further includes a first sealing member extending in a peripheral direction along a portion of the side surface of the substrate.

  • BIOLOGICAL AND CHEMICAL PROCESS UTILIZING CHEMOAUTOTROPHIC MICROORGANISMS FOR THE CHEMOSYTHETIC FIXATION OF CARBON DIOXIDE AND/OR OTHER INORGANIC CARBON SOURCES INTO ORGANIC COMPOUNDS, AND THE GENERATION OF ADDITIONAL USEFUL PRODUCTS

    The invention described herein presents compositions and methods for a multistep biological and chemical process for the capture and conversion of carbon dioxide and/or other forms of inorganic carbon into organic chemicals including biofuels or other useful industrial, chemical, pharmaceutical, or biomass products. One or more process steps utilizes chemoautotrophic microorganisms to fix inorganic carbon into organic compounds through chemosynthesis. An additional feature described are process steps whereby electron donors used for the chemosynthetic fixation of carbon are generated by chemical or electrochemical means, or are produced from inorganic or waste sources. An additional feature described are process steps for the recovery of useful chemicals produced by the carbon dioxide capture and conversion process, both from chemosynthetic reaction steps, as well as from non-biological reaction steps.

  • Chemical Admixtures for Hydraulic Cements

    This invention relates to a new class of chemical admixtures for hydraulic cement compositions such as pastes, mortars, grouts and concretes. The cement compositions are comprised of ordinary Portland cement, blended cements, or non-Portland cements made with Supplementary Cementitious Materials. The admixtures contain complexes of metals with derivatives of hydroxycarboxylic acids, and improve properties of cement compositions, including setting, hardness, compressive strength, shrinkage, and freeze-thaw resistance. The invention discloses a method for improving the properties of hydraulic cements by adding the disclosed chemical admixtures to cement compositions, and also discloses methods of preparing said admixtures.

  • APPARATUS FOR HIGH THROUGHPUT CHEMICAL REACTIONS

    Apparatus, systems, chips, and methods of performing a large number of simultaneous chemical reactions are provided herein. The chips of the invention comprise addressable units that can be addressed according to the temperature of the reaction to be run. The subject apparatus, systems, and chips are particularly suited for performing polymerase chain reactions on thousands of nucleic acid sequences, up to and including sequences of an entire genome of an organism of interest.

  • SYSTEM AND METHODS FOR PREPARING FREESTANDING FILMS USING LASER-ASSISTED CHEMICAL ETCH, AND FREESTANDING FILMS FORMED USING SAME

    Systems and methods for preparing freestanding films using laser-assisted chemical etch (LACE), and freestanding films formed using same, are provided. In accordance with one aspect a substrate has a surface and a portion defining an isotropically defined cavity; and a substantially continuous film is disposed at the substrate surface and spans the isotropically defined cavity. In accordance with another aspect, a substrate has a surface and a portion defining an isotropically defined cavity; and a film is disposed at the substrate surface and spans the isotropically defined cavity, the film including at least one of hafnium oxide (HfO.sub.2), diamond-like carbon, graphene, and silicon carbide (SiC) of a predetermined phase. In accordance with still another aspect, a substrate has a surface and a portion defining an isotropically defined cavity; and a multi-layer film is disposed at the substrate surface and spans the isotropically defined cavity.

  • Methods Of Modeling Physical Properties Of Chemical Mixtures And Articles Of Use

    Included are methods for modeling at least one physical property of a mixture of at least two chemical species. One or more chemical species of the mixture are approximated or represented by at least one conceptual segment. The conceptual segments are then used to compute at least one physical property of the mixture. An analysis of the computed physical properties forms a model of at least one physical property of the mixture. Also included are computer program products and computer systems for implementing the modeling methods.

  • CHEMICAL DISPERSION METHOD AND DEVICE

    A method of semiconductor fabrication including providing a semiconductor wafer and dispensing a first chemical spray onto the wafer using a first nozzle and dispensing a second chemical spray using a second nozzle onto the wafer. These dispensing may be performed simultaneously. The method may further include moving the first and second nozzle. The first and second nozzle may provide the first and second chemical spray having at least one different property. For example, different chemical compositions, concentrations, temperatures, angles of dispensing, or flow rate. A chemical dispersion apparatus providing two nozzles which are operable to be separately controlled is also provided.

  • User Targeted Medical Imaging And Information Packaging, Compression And Distribution System

    A computer-based method and system of distributing biological sample data acquired as a digital image of a subject biological sample. The acquired digital image and image capture data are processed according to at least one user. This results in processed image data and capture metadata. The processed image data represents biological sample data of the subject biological sample. A package processing combines the processed image data and capture metadata into a working Package. The method and system enables simultaneous electronic access to the working Package by multiple users, across multiple sectors, in addition to the one user.

  • IMAGING DEVICE AND METHODS OF USING THE SAME

    In one embodiment, a medical device includes a first optical fiber, a second optical fiber, a third optical fiber, and a fourth optical fiber. The first optical fiber is operatively coupled to a first electromagnetic radiation source and is configured to transmit electromagnetic radiation to bodily tissue. The second optical fiber is configured to receive electromagnetic radiation from the first electromagnetic radiation source scattered by the bodily tissue. The third optical fiber is operatively coupled to a second electromagnetic radiation source and is configured to transmit electromagnetic radiation to bodily tissue. The second electromagnetic radiation source is different than the first electromagnetic radiation source. The fourth optical fiber is configured to receive electromagnetic radiation from the second electromagnetic radiation source scattered by the bodily tissue.

  • Visualization of Associated Information in Ultrasound Shear Wave Imaging

    Information associated with shear calculation is also displayed in ultrasound shear wave imaging. More information than just a shear wave image is provided for diagnosis. Information about the quality or variables used to determine shear is also displayed. This additional information may assist the user in determining whether the shear information indicates tissue characteristics or unreliable shear calculation.

  • PORTABLE PET SCANNER FOR IMAGING THE HUMAN BRAIN

    In accordance with at least one disclosed embodiment, an apparatus for use in imaging the human brain by describing the distribution of radiotracers in the human brain is provided. The apparatus may be compact and lightweight enough to be lifted by hand (less than 50 pounds) and affixed to a patient bed. In addition, the apparatus may collect images of both the cerebrum and cerebellum of the patient.

  • WIRELESS INTRA-ORAL IMAGING SYSTEM AND METHOD

    An intra-oral imaging system includes a handheld intra-oral camera in wireless communication with a remote computing device. The computing device includes a display unit and is linked to databases containing historical data for the teeth of a subject. A dentist actuates a touch-sensitive button to prompt capture of images of the subject's teeth, which are wirelessly transmitted to the computing device and graphically displayed. The images generally represent an arrangement and conditions for the teeth. Program modules are executable to identify a current condition of one or more teeth, and to select a prerecorded visual demonstration of a dental procedure from a database based on the identified current condition. Alternatively, the program modules may extrapolate using the current and historical data to predict a future condition and recommend procedures or otherwise alert the subject to potential future procedures. Visual demonstration of the procedures is provided on the display unit.

  • METHODS AND COMPOSITIONS FOR NON-INVASIVE, DYNAMIC IMAGING OF INTESTINAL MOTILITY

    Described are methods and composition for use in non-invasive imaging of intestinal structure and function. These methods can be used to identify, diagnose, assess, monitor and direct therapies for gastrointestinal diseases and disorders. Embodiments of the methods utilize highly sensitive optical imaging and fluorescent spectroscopy techniques to track or monitor packets of organic dye excreted in bile into the intestinal tract to provide quantitative information regarding intestinal propulsion and function.

  • ADAPTIVE IMAGING AND FRAME RATE OPTIMIZING BASED ON REAL-TIME SHAPE SENSING OF MEDICAL INSTRUMENTS

    A system and method for adaptive imaging include a shape sensing system (115, 117) coupled to an interventional device (102) to measure spatial characteristics of the interventional device in a subject. An image module (130) is configured to receive the spatial characteristics and generate one or more control signals in accordance with the spatial characteristics. An imaging device (110) is configured to image the subject in accordance with the control signals.

  • FUNDUS IMAGING APPARATUS AND METHOD

    In order to suppress a load on a subject when a fundus is irradiated with multiple beams, a fundus imaging apparatus for forming an image of a first area in the object, includes: a determination unit for determining a second area other than the first area in the object to be inspected; a detection unit for detecting moving of the object to be inspected on the basis of return light from the second area, which is irradiated with second light; a correction unit for correcting the first area on the basis of the detected moving; and a forming unit for forming an image of the object to be inspected on the basis of the return light from the corrected first area, which is irradiated with the first light.

  • LASER ABLATION ELECTROSPRAY IONIZATION (LAESI) FOR ATMOSPHERIC PRESSURE, IN VIVO, AND IMAGING MASS SPECTROMETRY

    The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI).

  • SYSTEMS, DEVICES AND METHODS FOR IMAGING AND SURGERY

    Provided herein are devices, systems and methods for treating a vocal fold pathology by forming a substantially planar void below the epithelium of the vocal fold using optical energy. Also provided are devices, systems, and methods for combined imaging and treating of a vocal fold pathology.

  • IMPLANTABLE CARDIOVERTER DEFIBRILLATOR DESIGNED FOR USE IN A MAGNETIC RESONANCE IMAGING ENVIRONMENT

    An implantable cardioverter defibrillator includes a communication interface operable to receive a communication signal from an external programmer. The communication signal includes a command to switch the ICD from a first mode to a second mode. A processor is in electrical communication with the communication interface and configured to switch the ICD between the first and second modes. A battery is configured to supply low DC voltage. A converter is configured to convert the low DC voltage to a high DC voltage. An energy storage capacitor is electrically coupled to the converter and configured to store a therapeutic energy or high DC voltage including at least 15 joules. The second mode includes activating the converter to convert the low DC voltage to the high DC voltage and storing the therapeutic energy or at least 15 joules within the energy storage capacitor during a period of time of the second mode.

  • LENS DESIGNS FOR INTEGRAL IMAGING 3D DISPLAYS

    Integral imaging 3D films for use with a display panel. The films include a flexible transmissive substrate having a first surface on a viewer side and a second surface for placement on the display panel. Convex lenses are located on the first surface. The second surface is planar for a plano-convex design or has concave lenses registered with the convex lenses for a convex-concave compound lens design. In the plano-convex design, the lens focus is in front of or behind the pixels. In the convex-concave design, the convex and concave lenses combined focus is in front of, at, or behind the pixels. In use the 3D films produce 3D images with motion parallax.

  • SPATIALLY RESOLVED SPECTRAL-IMAGING DEVICE

    A spatially resolved spectral device comprising a dispersive array to receive an incident light comprising a principal ray. The dispersive array comprising a plurality of dichroic layers, each of the plurality of dichroic layers disposed in a path of a direction of the principal ray. Each of the plurality of dichroic layers configured to at least one of reflect or transmit a different wavelength range of the incident light. The device further comprising a detection array operatively coupled with the dispersive array. The detection array comprising a photosensitive component including a plurality of detection pixels, each of the plurality of detection pixels having a light-receiving surface disposed parallel to the direction of the principal ray to detect a respective one of the different wavelength ranges of incident light reflected from a corresponding one of the plurality of dichroic layers.

  • SENSOR-SYNCHRONIZED SPECTRALLY-STRUCTURED-LIGHT IMAGING

    A smartphone is adapted for use as an imaging spectrometer, by synchronized pulsing of different LED light sources as different image frames are captured by the phone's CMOS image sensor. A particular implementation employs the CIE color matching functions, and/or their orthogonally transformed functions, to enable direct chromaticity capture. A great variety of other features and arrangements are also detailed.

  • SYSTEMS AND METHODS FOR CARTESIAN DYNAMIC IMAGING

    Systems and methods for Cartesian dynamic imaging are disclosed. In one aspect, in accordance with one example embodiment, a method includes acquiring magnetic resonance data for an area of interest of a subject that is associated with one or more physiological activities of the subject and performing image reconstruction comprising Kalman filtering or smoothing on Cartesian images associated with the acquired magnetic resonance data. Performing the image reconstruction includes increasing at least one of spatial and temporal resolution of the Cartesian images.

  • COMPUTERIZED IMAGING OF SPORTING TROPHIES AND USES OF THE COMPUTERIZED IMAGES

    Methods are disclosed for providing replicas of a sporting trophy and for scoring the sporting trophy. The first method includes providing a sporting trophy to be scanned, scanning the sporting trophy to provide three-dimensional image data of the sporting trophy, and providing the three-dimensional image data of the sporting trophy to a replica generating system to provide a replica of the sporting trophy. The second method includes providing three-dimensional digital data of a sporting trophy having a volume and a surface area, providing at least one sporting-relevant measurement based on the three-dimensional data of the sporting trophy, and providing a score of the sporting trophy based on the at least one sporting-relevant measurement.

  • SYSTEMS AND METHODS FOR IMPLEMENTING DYNAMIC USER INTENT-BASED IMAGING OPTIONS IN IMAGE FORMING AND DOCUMENT HANDLING SYSTEMS

    A system and method are provided to implement dynamic user intent-based imaging operations in image forming and document handling systems. A common framework is provided to implement the user-intent based imaging operations by which all of the individual component devices are able to be mapped to a particular user's desires such that an output from any particular image forming device in the complex image forming system meets the user's requirements/intent. Operations of component devices of a particular complex image forming system are defined logically. Mappings to the individual devices according to a common reference framework are then overlaid and manipulated according to the common framework. In this manner, a user directs imaging operations, including image shifts, for individual pages, subsets of pages or an entire document in the manner the user intends rather than according to a default understanding of the device.

  • CUINSE/ZNS NIR-QUANTUM DOTS (QDS) FOR BIOMEDICAL IMAGIING

    Applications in nanomedicine, such as diagnostics and targeted therapeutics, rely on the detection and targeting of membrane biomarkers. Disclosed herein are functionalized quantum dots exhibiting greater stability in water, methods of making the functionalized quantum dots and methods of in vivo imaging using the functionalized quantum dots.

  • IMAGING BY EXTRAPOLATION OF VECTOR-ACOUSTIC DATA

    Methods for wavefield extrapolation using measurements of a wavefield quantity and a component of the gradient of the wavefield quantity are disclosed. The methods use "exact" representations of scattering reciprocity. The methods can yield "exact", nonlinear, "true-amplitude" receiver wavefields that are beyond the receiver measurement boundary. Methods of evaluating/validating the extrapolated data are also disclosed. Some methods may also evaluate the accuracy of models for the areas where data are extrapolated or measured. These methods can be used in any industries involving imaging, such as geophysical/seismic exploration, bio-medical imaging, non-destructive remote sensing, acoustic space architecture, design and engineering.

  • IMAGING DEVICE WITH IMAGE ACQUISITION RATE OPTIMIZATION

    The disclosure includes a method of acquiring high-resolution ultrasound images using an array of transducers using successive transmission matrices. Implementations include operations for determining inter-transducer correlation matrices of an area of interest and an unwanted area; determining a characteristic matrix of the area of interest from the product of the inverse of the inter-transducer correlation matrix of the unwanted area and the inter-transducer correlation matrix of the area of interest; calculating eigenvectors and values of the characteristic matrix to define a transmission matrix; adjusting the image acquisition rate and image quality in order to define eigenvectors for firing; multiplying a reception matrix comprising the acquired signals completed by data set to zero corresponding to the firings not effected by the inverse of the transmission matrix to obtain a complete data set; reconstructing a high-resolution image of the area of interest as in synthetic aperture echographic imaging methods.

  • LINE-FIELD HOLOSCOPY

    A novel imaging method, line-field holoscopy is presented. A line of light is projected across an object to be investigated through an imaging system. The light scattered from the investigated object is combined with reference radiation. The combined light is projected onto a detector providing a confocal restriction in one dimension. Astigmatic optics in the return path transform the light asymmetrically such that at the detector, the line focus is imaged to the confocal restriction, while the orthogonal direction is defocused. Embodiments including a swept source with linear detection array, and spectrometer based systems utilizing a 2D detector array are described. The data may be reconstructed to a B-scan by two-dimensional Fourier transform or other reconstruction method with or without combination of more complex algorithms.

  • HIGH-VALENT PALLADIUM FLUORIDE COMPLEXES AND USES THEREOF

    The present invention provides novel high-valent palladium complexes. The complexes typically include multi-dentate ligands that stabilize the octahedral coordination sphere of the palladium(IV) atom. These complexes are useful in fluorinating organic compounds and preparing high-valent palladium fluoride complexes. The invention is particularly useful for fluorinating compounds with .sup.19F for PET imaging.