The objective of present study was to formulate and evaluate sustained release tablets of Eperisone hydrochloride. The matrix tablets containing eperisone hydrochloride 75 mg were formulated using release retarding polymers such as hydroxy propyl methyl cellulose (HPMC K4M), xanthan gum in combination with other standard excipients. The formulated tablets obtained by the direct compression method and were evaluated for physical characteristics viz, hardness, thickness, friability, percentage weight variation. The results of all the evaluation parameters were in the limits. Further, tablets were evaluated for in-vitro release characteristics for 12 hrs. Batches B1, B2 and B3 showed release 80.21%, 79.58% and 78.41% at 12th hr respectively. While, batch B4, B5 and B6 showed release 76.45%, 76.22% and 73.25% at 12th hr respectively. Release kinetics of all the batches was evaluated. The formulations B1, B2, B3, B4, B5 were followed Korsmeyer–peppas model, whereas B6 formulation showed zero order kinetics. The stability studies of the optimised formulation were performed as per ICH guidelines and were found to be stable. The designed eperisone hydrochloride sustained release matrix tablets have potential for sustained action of eperisone hydrochloride.
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