In all over the world, High levels of cholesterol or hypercholesterolemia are an important risk factor for coronary heart disease. The pivotal motif of the present research was to formulate the two drug in bilayer tablet in the form of immediate release and sustained release layer for better patient compliance. Immediate release layer was formulated by using the excipients like microcrystalline cellulose, crosscarmellose sodium (Ac-di-sol), sodium starch gycolate (Explotab) and sustained release layer was formulated using polymers and gum like HPMC E15, HPMC K100M - CR, xanthan gum. The disintegration and dissolution study of the entire bilayer tablet was studied. Kinetic studies of optimized Immediate release layer (IR3) and sustained release layer (SR10) showed good linearity with regression coefficient of 0.9855 (Higuchi model) and 0.9899 (Zero order), respectively. The above results reveal that optimized immediate release layer of ezetimibe (IR3) and sustained release layer of simvastatin (SR10) might be suitable for the treatment of hypercholesterolemia by sequential release of two drugs in a bilayer tablets.
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