The study was aimed to formulate fast disintegrating of piroxicam by using superdisintegrants. Development of oral fast disintegrating drug delivery is to give fast relief and also to overcome difficulty in swallowing tablets that leads to non-compliance and ineffective therapy. Piroxicam fast disintegrating tablets were prepared by using direct compression method and were characterized for both pre-compression and post-compression physical parameters. From the in-vitro drug release studies the optimized formulation showed fast drug release (above 99%) within the 15 minutes when compared with conventional tablet prepared in a similar manner with normal disintegrating agent. Differential scanning calorimetry (DSC) study was carried out to understand the drug-polymer compatibility and revealed that there was no possible interaction between them. Thus usage of superdisintegrants to develope fast disintegrating tablets may be suitable to give rapid drug delivery and rapid onset of action.
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