Migraine is a common chronic disorder with episodic attacks. Zolmitriptan is an effective drug used for the treatment of migraine. This study aimed to formulate fast dissolving oral films (FDOFs) of zolmitriptan (FDOFs) using different polymers such as hydroxypropyl methylcellulose (HPMC), sodium carboxymethylcellulose (NaCMC), sodium alginate (Na alginate), hydroxyethyl cellulose (HEC), gelatin, polyvinyl alcohol (PVA) in addition to glycerin as a plasticizer. The films were prepared by solvent casting method. The prepared films were evaluated for peeling from Petri dish, color, transparency, homogeneity, average weight, thickness, disintegration, folding endurance, drug content and in-vitro drug release. Results showed that the film containing 1% PVA, 5 % mannitol and 10 % glycerin (F3) appeared to have superior properties as FDOF. The optimized film disintegrated within 9 seconds and released 100 % of zolmitriptan in 3 min. The folding endurance was satisfactory (˃300). Moreover, drug content was found to be 99.5 % and thickness was 0.08 mm.
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