Nanotechnology mediated drug transport presents a promising approach for targeted drug delivery owing to its capability of better stability and sustained drug release. Compared with different drug delivery techniques, nanoparticles have distinct advantages in improving the transport of drugs across the nasal mucosa. In the present work galantamine, an acetycholinesterase inhibitor used in the treatment of Alzheimer’s selected as model drug for nasal permeation study. Galantamine loaded chitosan and thiolated chitosan nanoparticles were formulated by ionic gelation method and characterized. Ex-vivo permeation of nanoparticles across nasal epithelium was evaluated by Franz diffusion cell. The polymeric mucoadhesive nanoparticles found to have better permeation across the nasal mucosa as compared to the drug solution.
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