The present investigation concerns the development of Gastroretentive floating matrix tablets, which after oral administration are designed to prolong the gastric residence time, increase the drug bioavailability and diminish the side effects of gastric irritating Diclofenac sodium by using Mango resin i.e., Mangifera indica and to study its release retardant activity in prepared floating formulation. Different concentrations of resin were tried in order to get the desired sustained release profile over a period of 12hr. sodium bicarbonate and citric acid were incorporated as gas generating agents. Various formulations were evaluated for precompression properties like flow of granules, bulk and tapped density, post compression properties like uniformity of weight, hardness, friability, thickness, invitro buoyancy characteristics, drug content, invitro drug release profile and mechanism of drug release. Prepared tablets exhibited satisfactory precompression and post compression properties. All the prepared batches showed good invitro buoyancy. It was also found that invitro drug release rate decreases with increases amount of natural retardant polymer mango resin. The kinetics of drug release from all the formulations followed the zero order by regression analysis and further mechanism of drug release was conformed by Higuchi�s and Korsemeyer�s model showed that non-fickian and anomalous drug releases. Finally optimized formulation F4 was compared with marketed Voveran SR tablet of Diclofenac sodium was showed similar release profile with similarity factor value 90.12.
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