The objective of this study was to compare between the in traditional in vitrotesting and dissolution\nkinetics of selected commercial brands of ibuprofen and paracetamol tablets. Ibuprofen (400 mg/Tab)\nand paracetamol tablets (500 mg/Tab) from the Gulf Cooperation Council (GCC) pharmaceutical\nmarket were evaluated for hardness, friability, uniformity of weight, disintegration and dissolution\nprofiles. The study indicated that there is a correlation between the different in vitro tests proposing that\ntablets with higher hardness value, slow disintegration time will show slower dissolution rate. The\nresults indicated a significance difference between different brands in hardness, disintegration time and\ndissolution. This difference was more prominent for ibuprofen brands compared to paracetamol brands.\nThe similarity test supported this findings where f2 for all comparisons for the ibuprofen tablets were\nless than 50. Dissolution kinetics indicated that the first order equation was best equation to give the\ngoodness of fit and therefore to represent the dissolution data. The dissolution kinetics confirmed the\ndifference between different brands of both ibuprofen and paracetamol tablets. The use of dissolution\nkinetics proved to be a good tool in studying the interchangeability of generic drugs. The study raise a\nvaluable question about the interchangeability of different brands as this in vitro difference may suggest\na more serious in vivo difference in their bioavailability.
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