Objective: The present study investigates the capability of preparing metronidazole loaded\nmicrospheres employing a natural chitosan extracted from oyster shells of Egeria radiata.\nMethods: Microspheres were prepared by external gelation technique using tripolyphosphate\n(TPP) as the cross-linker. The drug to polymer ratio was selected at various levels of polymer-drug\nquantities with varying amount of TPP. The prepared microspheres were characterized for % yield,\ndrug entrapment efficiency, surface morphology and drug release profile.\nResults: Almost spherical, rough and porous microspheres were obtained. % yield and drug\nentrapment efficiency were found to be in the range of 63.5 ââ?¬â?? 70.8% and 63.4 ââ?¬â?? 77.5%\nrespectively; and about 80% of the drug was released in about 6 hours.\nConclusion: The results revealed that formulation of metronidazole loaded microspheres in\nnatural chitosan from an oyster shell can be used as a potential oral drug delivery system.
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