Lipid nanocarriers show occlusive properties that may be related to their ability to improve\nskin hydration. The aim of this work was to evaluate the relationship between in vitro occlusion factor\nand in vivo skin hydration for three types of lipid nanocarriers: nanoemulsions (NEs), solid lipid\nnanoparticles (SLNs) and nanostructured lipid carriers (NLCs). These lipid nanocarriers were loaded\nwith trans-resveratrol (RSV) and incorporated in gel vehicles. In vitro occlusion factor was in the\norder SLNs > NLCs > NEs. Gels containing unloaded or RSV loaded lipid nanocarriers were applied\non the back of a hand of 12 healthy volunteers twice a day for one week, recording skin hydration\nchanges using the instrument Soft Plus. An increase of skin hydration was observed for all lipid\nnanocarriers (SLNs > NLCs > NEs). RSV loading into these nanocarriers did not affect in vitro and\nin vivo lipid nanocarriers effects. A linear relationship (r2 = 0.969) was observed between occlusion\nfactor and in vivo increase of skin hydration. Therefore, the results of this study showed the feasibility\nof using the occlusion factor to predict in vivo skin hydration resulting from topical application of\ndifferent lipid nanocarriers loading an active ingredient with no inherent hydrating activity.
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